grant
Single cell quantification of translation control in early mouse development
Organization UNIVERSITY OF TEXAS AT AUSTINLocation AUSTIN, UNITED STATESPosted 1 Aug 2023Deadline 30 Jun 2028
NIHUS FederalResearch GrantFY2025AddressAllelesAllelomorphsBirth DefectsBlastosphereCell BodyCellsCongenital AbnormalityCongenital Anatomical AbnormalityCongenital DefectsCongenital DeformityCongenital MalformationDevelopmentEmbryoEmbryo DevelopmentEmbryogenesisEmbryonicEmbryonic DevelopmentGene ExpressionGene TranscriptionGenetic TranscriptionGenomeMeasurementMessenger RNAMethodsMiceMice MammalsMurineMusNucleotidesPre-implantation Embryo DevelopmentPre-implantation developmentPreimplantation EmbryoPreimplantation Embryo DevelopmentPreimplantation developmentProcessProductivityProtein BiosynthesisProteinsProteomeRNA ExpressionResearchResolutionRibo-seqRibosomal Peptide BiosynthesisRibosomal Protein BiosynthesisRibosomal Protein SynthesisRibosomesShapesTechnologyTranscriptionTranslational InhibitionTranslational RepressionTranslationsblastocystblastuladevelopmentalglobal gene expressionglobal transcription profileinnovateinnovationinnovativeinsightmRNAmouse developmentposttranscriptionalpre-implantation embryopreimplantationpreventpreventingprogramsprotein synthesisresolutionsribosome footprint profilingribosome profilingtranscriptometranslationvertebrate embryos
Description preview
The initial stages of vertebrate embryo development proceed in the absence of transcription.
Consequently, protein abundance of preimplantation embryos is regulated by post-transcriptional
gene expression programs. In particular, new protein synthesis is required for productive
embryogenesis as inhibition of translation prevents activation of the…
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