grant
Single cell opioid (fentanyl) responses in the context of HIV
Organization UNIVERSITY OF CINCINNATILocation CINCINNATI, UNITED STATESPosted 15 Jul 2025Deadline 31 Mar 2030
NIHUS FederalResearch GrantFY202521+ years oldAIDS VirusAcquired Immune Deficiency Syndrome VirusAcquired Immunodeficiency Syndrome VirusActiqAdultAdult HumanAffectAgeAlcohol Chemical ClassAlcoholsAnti-HIV PositivityApoptosisApoptosis PathwayAreaAtlasesB blood cellsB cellB cellsB-CellsB-LymphocytesB-cellBioinformaticsBlood CellsBlood SampleBlood monocyteBlood specimenCD4 CellsCD4 Positive T LymphocytesCD4 T cellsCD4 helper T cellCD4 lymphocyteCD4+ T-LymphocyteCD4-Positive LymphocytesCD8 CellCD8 T cellsCD8 lymphocyteCD8+ T cellCD8+ T-LymphocyteCD8-Positive LymphocytesCD8-Positive T-LymphocytesCell BodyCell CommunicationCell Communication and SignalingCell InteractionCell SignalingCell-to-Cell InteractionCellsChemotactic CytokinesCocaineCommunitiesCrystal MethCrystal methamphetamineCytotoxic cellDataDendritic CellsDeoxyephedrineDesoxyephedrineDiacetylmorphineDiamorphineDiseaseDisorderDrug PrescribingDrug PrescriptionsDrug usageDrugsDuragesicEnrollmentFatality rateFentanestFentanylFentylFundingGene ExpressionGenesHCVHCV infectionHIVHIV InfectionsHIV PositiveHIV PositivityHIV SeroconversionHIV SeropositivityHIV antibody positiveHIV diagnosisHTLV-III InfectionsHTLV-III SeroconversionHTLV-III SeropositivityHTLV-III-LAV InfectionsHepatitis C virusHepatitis C virus infectionHepatocarcinogenesisHeroinHomologous Chemotactic CytokinesHuman Immunodeficiency VirusesHuman T-Lymphotropic Virus Type III InfectionsIFNImmuneImmunesIn VitroIndividualInfectionInjecting drug userInjection Drug UserInnate Immune ResponseIntercrinesInterferon Type IInterferonsIntracellular Communication and SignalingK lymphocyteLAV-HTLV-IIILiquid ChromatographyLiver CarcinogenesisLocationLymphadenopathy-Associated VirusMacrophageMarrow monocyteMediatingMedicationMedicineMethamphetamineMethylamphetamineMicroRNAsModelingMorbidityMorbidity - disease rateMφN-MethylamphetamineNIDANK CellsNational Institute of Drug AbuseNational Institute on Drug AbuseNatural Killer CellsOhioOpiate ReceptorsOpiatesOpioidOpioid ReceptorOverdosePBMCPWIDParticipantPathogenesisPathologyPathway interactionsPatientsPeripheralPeripheral Blood CellPeripheral Blood Mononuclear CellPersonsPharmaceutical PreparationsPhentanylPopulationPredispositionProgrammed Cell DeathRT-PCRRecreationResearchReverse Transcriptase Polymerase Chain ReactionRiskSIS cytokinesSamplingSignal TransductionSignal Transduction SystemsSignalingSusceptibilityT4 CellsT4 LymphocytesT8 CellsT8 LymphocytesTimeTranslational ResearchTranslational ScienceUniversitiesValidationVeiled CellsViralViral DiseasesViral GenesVirusVirus DiseasesVirus-HIVabused drugabused drugsaddictionaddictive disorderadulthoodagesbiological signal transductioncarcinogenesis in the livercell typechemoattractant cytokinechemokinecohortcollegecollegiatecytokinedifferential expressiondifferentially expresseddrug abuseddrug of abusedrug usedrug/agentdrugs abuseddrugs of abuseenrollexperimentexperimental researchexperimental studyexperimentsfentalogsfentaloguesfentanyl analogfentanyl useglobal gene expressionglobal transcription profilehepatic carcinogenesishepatitis C infectionhepatocellular carcinogenesisin vivoinfected with HCVinfected with hepatitis Cinfected with hepatitis C virusinfection by hepatitis c virusinfection with HCVinfection with hepatitis Cinfection with hepatitis C virusinjection drug useliver cancer pathogenesisliver tumorigenesismedication prescriptionmethmiRNAmonocytemortalitymultiomicsmultiple omicsnovelopiate consumptionopiate crisisopiate drug useopiate intakeopiate overdoseopiate related overdoseopiate useopioid consumptionopioid crisisopioid drug overdoseopioid drug useopioid epidemicopioid induced overdoseopioid intakeopioid intoxicationopioid medication overdoseopioid overdoseopioid poisoningopioid related overdoseopioid toxicityopioid useoverdose deathoverdose fatalitiespanomicspathwaypeople who inject drugspeople who inject illicit drugsperipheral bloodpersons who inject drugsprescribed medicationreceptor expressionresponsereverse transcriptase PCRscRNA sequencingscRNA-seqsingle cell RNA-seqsingle cell RNAseqsingle cell expression profilingsingle cell transcriptomic profilingsingle-cell RNA sequencingsynthetic opiatesynthetic opioidtandem mass spectrometrytherapy optimizationtranscriptional differencestranscriptometranslation researchtranslational investigationtreatment optimizationvalidationsviral infectionvirus infectionvirus-induced disease
Description preview
Abstract
The number of drug overdose deaths has increased significantly in recent years. By 2019, 70.6% of drug
overdose deaths involved opioids, and in Ohio, >90% of unintentional overdose deaths involved fentanyl.
Opioid receptors are expressed in multiple peripheral blood mononuclear cell (PBMC) types that are
susceptible to HIV infection but…
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