grant
SHePREG: Study of Heart function in PRE-Eclampsia during and after PreGnancy
Organization PENNSYLVANIA STATE UNIV HERSHEY MED CTRLocation HERSHEY, UNITED STATESPosted 14 Jan 2025Deadline 31 Dec 2029
NIHUS FederalResearch GrantFY2026AffectAreaAsian FemalesAsian WomenAsymmetric Septal HypertrophyAttenuatedBlackBlack raceCardiac DiseasesCardiac DisordersCardiac Function StudyCardiac Muscle CellsCardiac MyocytesCardiocyteCardiomyopathiesCardiovascular DiseasesCessation of lifeCoronary Function StudyDataDeathDevelopmentDiseaseDisorderDisproportionate number of femalesDisproportionate number of womenDisproportionately affects femalesDisproportionately affects womenDisproportionately impacts femalesDisproportionately impacts womenDisproportionately in femalesDisproportionately in womenDysfunctionEPH GestosisEnrollmentEthnic OriginEthnicityFailureFounder EffectFunctional disorderFutureGeneticGenetic PolymorphismGenetic RiskGestationGoalsHealthHeart DiseasesHeart Function StudyHeart Muscle CellsHeart failureHeart myocyteHereditary ventricular hypertrophyHigh Risk WomanHispanicHumanHypertension-Associated Pregnancy DisorderHypertrophic CardiomyopathyHypertrophic Obstructive CardiomyopathyIdiopathic Hypertrophic Subvalvular StenosisIdiopathic hypertrophic subaortic stenosisIndividualInvestigationKineticsLeftLinkLive BirthMedicineModern ManMorbidityMyocardial DiseasesMyocardial DisorderMyocardial depressionMyocardial dysfunctionMyocardiopathiesNon-HispanicNonhispanicNot Hispanic or LatinoPathogenicityPathway interactionsPatternPerinatalPeripartumPhenotypePhysiopathologyPost-partum WomenPostpartum PeriodPostpartum WomenPre-EclampsiaPreeclampsiaPregnancyPregnancy ToxemiasProteinsProteinuria-Edema-Hypertension GestosisRaceRacesRacial GroupResearchRestRiskSarcolemmaSarcoplasmic ReticulumScienceStressTestingTimeUnited StatesVariantVariationVentricularWomanWorkafter pregnancyat-risk femalesat-risk womenattenuateattenuatescardiac dysfunctioncardiac failurecardiac functioncardiac myocytes differentiated from induced pluripotent stem cellcardiomyocytecardiovascular disordercohortdeath among pregnantdeath during pregnancydevelopmentalenrollexperiencefemale biasfemale predominancefemale preponderancefemales at high riskfunction of the heartheart cellheart disorderheart dysfunctionheart functionhiPSChigh riskhigh risk femaleshuman iPShuman iPSChuman induced pluripotent cellhuman induced pluripotent stem cellshuman inducible pluripotent stem cellshuman inducible stem cellshypertensivehypertensive disease during pregnancyhypertensive disease in pregnancyhypertensive disease of pregnancyhypertensive disorder during pregnancyhypertensive disorder in pregnancyhypertensive disorder of pregnancyhypertrophic myocardiopathyiPS cell derived cardiomyocytesiPSC derived cardiomyocytesimprovedin silicoinduced human pluripotent stem cellsinduced pluripotent stem cell derived cardiac myocytesinduced pluripotent stem cell derived cardiomyocytesinducible pluripotent stem cell derived cardiac myocytesinducible pluripotent stem cells derived cardiomyocytesinnovateinnovationinnovativemigrationmortalitymortality during pregnancymortality in pregnancymutantmyocardium diseasemyocardium disordernew drug treatmentsnew drugsnew pharmacological therapeuticnew therapeuticsnew therapynext generation therapeuticsnovel drug treatmentsnovel drugsnovel pharmaco-therapeuticnovel pharmacological therapeuticnovel therapeuticsnovel therapyobstetric mortalitypathophysiologypathwaypolymorphismpost pregnancypost-partumpre-eclampticpredominance in femalespredominance in womenpregnancy associated deathpregnancy associated maternal deathpregnancy associated mortalitypregnancy deathpregnancy disorderpregnancy induced hypertensive disorderpregnancy mortalitypregnancy related deathpregnancy related hypertensive diseasepregnancy related maternal deathpregnancy related mortalitypregnancy toxemia/hypertensionpregnancy-specific hypertensive disorderracialracial backgroundracial diversityracial originracial populationracial subgroupracially diverseresponsesocialsouth east asiansoutheast Asianwomen at high riskwomen's predominancewomen's preponderance
Description preview
Project Summary/Abstract
Advances in medicine and science have led to improved health in women, yet hypertensive disorders of
pregnancy such as pre-eclampsia (PreE) remain one of the reasons that maternal cardiac disease is a leading
cause of pregnancy-related death in the United States. In this project we examine the impact of severe PreE
on…
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