grant
SGLT2 inhibitor therapy in islet transplantation
Organization UNIVERSITY OF MINNESOTALocation MINNEAPOLIS, UNITED STATESPosted 1 Feb 2026Deadline 31 Dec 2028
NIHUS FederalResearch GrantFY2026Adjuvant StudyAdjuvant TherapyAdjuvant TrialsAllograftingArea Under CurveAutograftAutologous TransplantationAutotransplantBeta CellBlindedBlood GlucoseBlood SerumBlood SugarBrittle Diabetes MellitusC-PeptideCell TherapyCellular StressCellular Stress ResponseClinicalClinical TrialsD-GlucoseDataDextroseDiabetes MellitusDiabetic AcidosisDiabetic KetoacidosisDiabetic KetosisDoseDrugsER stressEngraftmentEnrollmentFastingFunding OpportunitiesFutureGeneticGlucoseGlycohemoglobin AGlycosylated hemoglobin AGraft SurvivalHb A1Hb A1a+bHb A1cHbA1HbA1cHemoglobin A(1)HomeHospitalsHourHumanHumulin RHyperglycemiaHypoglycemiaIDDMImmunomodulationImmunosuppressionImmunosuppression EffectImmunosuppressive EffectInstitutionInsulinInsulin CellInsulin ResistanceInsulin Secreting CellInsulin deficiencyInsulin-Dependent Diabetes MellitusIntractable PainIslands of Langerhans TransplantationIslands of Pancreas TransplantationIslet CellIslets of Langerhans GraftingIslets of Langerhans TransplantationJuvenile-Onset Diabetes MellitusKetonesKetosisKetosis-Prone Diabetes MellitusMeasuresMedicationMetabolicMetabolic stressModelingModern ManNovolin ROperative ProceduresOperative Surgical ProceduresOralOutcomePancreatic Islets TransplantationParticipantPatient Outcomes AssessmentsPatient Reported MeasuresPatient Reported OutcomesPatientsPeptidesPharmaceutical PreparationsPhasePilot ProjectsPopulationProceduresProgenitor CellsProinsulinRandomization trialRandomizedRecurrenceRecurrentRefractory PainRegular InsulinResearchRiskSGLT 2 inhibitorSGLT2iSafetySerumSodium glucose co-transporter 2 inhibitorStandardizationStressSudden-Onset Diabetes MellitusSurgicalSurgical InterventionsSurgical ProcedureT1 DMT1 diabetesT1DT1DMTechnologyTestingTimeTotal PancreatectomyTransplantationType 1 Diabetes MellitusType 1 diabetesType I Diabetes MellitusVisitWeaningadjuvant protocoladjuvant treatmentalloimmunityallotransplantallotransplantationarmautoimmune beta cell destructionautoimmune islet destructionautologous graftautologous islet transplantationautotransplantationbeta cell autoimmunitycell based interventioncell mediated interventioncell mediated therapiescell replacement therapycell replacement treatmentcell stresscell-based therapeuticcell-based therapycellular therapeuticcellular therapychronic pancreatitisconnecting peptidedesigndesigningdiabetesdiabetes distressdiabetes-related distressdiabetes-specific distressdiabetic ketoacidoticdistress related to diabetesdistress specific to diabetesdrug/agentendoplasmic reticulum stressenrollfastedfastsglycemic controlhemoglobin A1chomeshyperglycemichypoglycemichypoglycemic episodesimmune modulationimmune regulationimmune suppressionimmune suppressive activityimmune suppressive functionimmunologic reactivity controlimmunomodulatoryimmunoregulationimmunoregulatoryimmunosuppressive activityimmunosuppressive functionimmunosuppressive responseimprovedinhibitor druginhibitor therapeuticinhibitor therapyinsulin dependent diabetesinsulin dependent type 1insulin resistantinsulin toleranceintervention effectintractable pain syndromeisletislet auto transplantationislet autoimmunityislet beta cell transplantationislet cell autoimmunityislet cell transplantislet cell transplantationislet progenitorislet stem cellsislet transplantationisoimmunityjuvenile diabetesjuvenile diabetes mellitusketosis prone diabetesmanufacturepain reliefpancreas progenitor cellpancreas stem cellspancreas total excisionpancreatic progenitorpancreatic progenitor cellpatient populationpilot studyprimary outcomepublic health relevancerandomisationrandomizationrandomized trialrandomly assignedrecurrent pancreatitisrelieve painresponsesafety and feasibilitysafety assessmentsafety studysecondary analysisside effectstandard carestandard treatmentstem cellssuccesssurgerytheoriestransplanttype I diabetestype one diabetesβ-cellβ-cellsβCell
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PROJECT SUMMARY
Islet transplantation is a promising treatment for insulin-dependent forms of diabetes, including type 1 diabetes
and surgical diabetes induced by total pancreatectomy. In the U.S., total pancreatectomy with islet
autotransplantation (TPIAT)—which is performed to relieve pain in patients with chronic pancreatitis-- has been
the…
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