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Sex-dependent regulation of social reward by oxytocin in the mesolimbic reward circuitry

Organization GEORGIA STATE UNIVERSITYLocation ATLANTA, UNITED STATESPosted 6 Apr 2021Deadline 30 Apr 2026 ⚠️
NIHUS FederalResearch GrantFY2025CRISPRCRISPR/Cas systemClinicalClustered Regularly Interspaced Short Palindromic RepeatsCricetinaeCyclicityDataDevelopmentDifferences between sexesDiffers between sexesDiseaseDisorderDopamineDoseFemaleGenderGoalsGolden HamstersGolden Syrian HamstersHamstersHamsters MammalsHydroxytyramineHypothalamic structureHypothalamusIncidenceKnowledgeLateralMaintenanceMeasuresMedialMediatingMesocricetus auratusNerve CellsNerve UnitNeural CellNeurocyteNeurodevelopmental DisorderNeurological Development DisorderNeuronsNucleus AccumbensOcytocinOxytocinOxytocin ReceptorPeriodicityPrefrontal CortexPrevalencePropertyPublishingReceptor ActivationRecombinant OxytocinRegulationRewardsRhythmicityRodentRodentiaRodents MammalsRoleSame-sexScanningSeriesSex DifferencesSexual differencesShapesSiteSocial BehaviorSocial InteractionSocial ValuesStimulusSymptomsSyrian HamstersSystemTestingVentral Tegmental Areaabused drugabused drugscomparing females and malescomparing women and mendevelopmentaldopamine systemdrug abuseddrug of abusedrugs abuseddrugs of abusefemales compared to malesfemales compared with malesfemales versus malesfemales vs. maleshypothalamicimprovedmalemesolimbic dopamine systemmesolimbic systemneural circuitneural circuitryneural mechanismneurochemicalneurochemistryneurocircuitryneurodevelopmental diseaseneuromechanismneuronalneuropsychiatric diseaseneuropsychiatric disordernovelpreferencepressureresponsereward circuitrysexsex based differencessex-dependent differencessex-related differencessex-specific differencesshRNAshort hairpin RNAsmall hairpin RNAsocialsocial relationshipssocial rolesociobehaviorsociobehavioralsynaptic circuitsynaptic circuitrytranslational opportunitiestranslational potentialventral tegmentumwomen compared to menwomen compared with menwomen versus menwomen vs. men

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Description preview

PROJECT SUMMARY
The rewarding properties of social interactions are critical to the expression of adaptive social behavior and to

the development and maintenance of social relationships. Little is known, however, about the factors that

determine the reward value of social interactions or about the basic neural mechanisms that underlie social…

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