grant
Serologic measures of enteric pathogen transmission for intervention studies and population monitoring in low-resource settings
Organization UNIVERSITY OF CALIFORNIA, SAN FRANCISCOLocation SAN FRANCISCO, UNITED STATESPosted 1 Sept 2022Deadline 31 Aug 2028
NIHUS FederalResearch GrantFY20250-11 years old0-4 weeks old7S Gamma GlobulinAdenoviridaeAdenovirusesAgeAntibodiesAntibody ResponseAntigensAscarisAssayBacteriaBangladeshBioassayBiological AssayBiological Specimen BanksBiological Substance BanksBirthBlood SampleBlood TestsBlood specimenC jejuniC parvumC. jejuniC. parvumCampylobacterCampylobacter jejuniChildChild YouthChildren (0-21)Cluster randomization trialCluster randomized trialCommunitiesComplementComplement ProteinsControl GroupsCountryCryptosporidiumCryptosporidium parvumDataDiarrheaDietary InterventionE histolyticaE. histolyticaETECEndamoeba histolyticaEnrollmentEnsureEntamoeba histolyticaEnteralEntericEpidemiologic MethodologyEpidemiologic MethodsEpidemiologic research methodologyEpidemiologic research methodsEpidemiological MethodsEpidemiological TechniquesFecesGeneralized GrowthGeographyGiardiaGrowthHandwashingHelminthsHematologic TestsHematological TestsHematology TestingHydrogen OxideIgGImmunoglobulin GInfectionInterventionIntervention StudiesKenyaLambliaLanguageLegal patentLow-resource areaLow-resource communityLow-resource environmentLow-resource regionLow-resource settingMapsMeasurementMeasuresMethodsMethods EpidemiologyMethods in epidemiologyModelingMolecularMonitorNewborn InfantNewbornsNorovirusNorwalk-like VirusesNutritionNutrition InterventionsNutritional InterventionsOutcome MeasureParasitic WormsParturitionPatentsPoliciesPopulationPopulation SurveillancePredispositionPregnant WomenPrevalencePublic HealthPublic Health SurveillanceR-Series Research ProjectsR01 MechanismR01 ProgramRandomization trialRandomizedResearchResearch GrantsResearch Project GrantsResearch ProjectsResource-constrained areaResource-constrained communityResource-constrained environmentResource-constrained regionResource-constrained settingResource-limited areaResource-limited communityResource-limited environmentResource-limited regionResource-limited settingResource-poor areaResource-poor communityResource-poor environmentResource-poor regionResource-poor settingS entericaS. entericaSalmonellaSalmonella entericaSamplingSanitationSapovirusSapporo-like VirusesSerologySerology testSeroprevalencesSoilStrongyloidesSusceptibilityTestingTimeTissue GrowthTransmissionViralVirusWaterWorkagesarmbiological specimen repositorybiosample repositorybiospecimen bankbiospecimen repositoryburden of diseaseburden of illnesscohortcomplementationcontinuous monitoringdiarrheal diseasediarrheal illnessdiet interventiondisease burdendisease controldisorder controlenrollenteral infectionenteral pathogenenteric infectionenteric pathogenenteric pathogen infectionenteropathogenenteropathogen infectionenteropathogenic infectionenterotoxigenic E colienterotoxigenic E. colienterotoxigenic E.colienterotoxigenic Escherichia colienvironmental interventionexpectant motherexpectant womenexpecting motherexpecting womenhand washinghelminth infectionhelminthic infectionimmunogenimprovedindividuals who are pregnantinfected with enteropathogeninfected with helminthinsightintervention effectintervention researchinterventional researchinterventional studyinterventions researchintestinal infectionintestinal pathogenintestine infectionintestine pathogenkidsmeasurable outcomemultiplex assaynewborn childnewborn childrenontogenyoutcome measurementpathogenpathogen exposurepeople who are pregnantpopulation basedpregnant femalespregnant motherspregnant peoplepregnant populationsprimary end pointprimary endpointprogramsprospectiverandomisationrandomizationrandomized trialrandomly assignedresponseseroconversionserology assayserology surveillanceserology surveyserosurveillanceserosurveyspatial epidemiologyspecimen bankspecimen repositorystoolthose who are pregnanttransmission processtrial designtrial enrollmentwomen who are pregnantyoungster
Description preview
Enteric pathogen infections cause an immense disease burden among children in low-resource settings.
Understanding pathogen-specific transmission in high burden populations, and whether transmission is reduced
through environmental intervention (reduced exposure) or improved nutrition (reduced susceptibility) is crucially
important for informing…
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