grant
Section on Neurobiology of Compulsive Behaviors
Organization NATIONAL INSTITUTE OF MENTAL HEALTHLocation UNITED STATES
NIHUS FederalResearch GrantFY202521+ years oldAcuteAdultAdult HumanAdverse ExperienceAdverse eventAlcohol Chemical ClassAlcohol DrinkingAlcohol consumptionAlcoholsAnatomic SitesAnatomic structuresAnatomyAnteriorAreaBasal GangliaBasal NucleiBedsBehaviorBehavioralBrainBrain Nervous SystemCaringCell Communication and SignalingCell SignalingComplexCompulsive BehaviorConnector NeuronConsumptionCorpus StriatumCorpus striatum structureD1 receptorDopamineDopamine D1 ReceptorDopamine ReceptorDorsalDown-RegulationDrugsEncephalonEnvironmentEquilibriumEtOH drinkingEtOH useFosteringGene TranscriptionGenetic TranscriptionGoalsHousingHydroxytyramineIndividualIntercalary NeuronIntercalated NeuronsInterneuronsInternuncial CellInternuncial NeuronIntracellular Communication and SignalingLifeLife ExperienceLogicMediatingMediationMedicationMesencephalonMethodsMiceMice MammalsMid-brainMidbrainMidbrain structureMissionModelingMotivationMurineMusNegotiatingNegotiationNerve CellsNerve UnitNeural CellNeurobiologyNeurocyteNeuronsOutcomePathway interactionsPharmaceutical PreparationsPositionPositioning AttributePredisposing FactorPropertyRNA ExpressionReceptor ProteinRegulationResearchRiskSample SizeSignal TransductionSignal Transduction SystemsSignalingStriate BodyStriatumSubstance Use DisorderSubstance of AbuseSynapsesSynapticTestingThalamic structureThalamusTranscriptionabused drugabused drugsadulthoodalcohol ingestionalcohol intakealcohol product usealcohol responsealcohol usealcoholic beverage consumptionalcoholic drink intakebalancebalance functionbiological signal transductioncholinergicdensitydrug abuseddrug of abusedrug/agentdrugs abuseddrugs of abuseearly adversityearly childhood adversityearly experienceearly life adversityethanol consumptionethanol drinkingethanol ingestionethanol intakeethanol product useethanol responseethanol useexperiencefrontal cortexfrontal lobeimprovedin vivomaleneurobiologicalneurobiological mechanismneuronalnovelpathwayperceptual stimulusphysicochemical phenomena related to the sensesposttranscriptionalprevent substance usereceptorreceptor densityrecruitresponse to alcoholresponse to ethanolreward circuitrysensory cortexsensory stimulussexsocialstriatalsubstance use and disordersubstance use preventionsubstances of abusesynapsethalamicvisual stimulus♂
Description preview
Early life adversity increases striatal density of dopamine D1 receptors and promotes social alcohol drinking in mice, especially males:
The brain’s reward circuitry remains sensitive to experience throughout early life and into adulthood, allowing individuals to adapt to their unique environments. It is thought that adverse experiences early in…
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