grant

SBIR TOPIC 111, PHASE II: A COMPACT PORTABLE MEDICAL OXYGEN GENERATOR

Organization TDA RESEARCH, INC.Location GOLDEN, UNITED STATESPosted 30 Sept 2025Deadline 29 Sept 2027
NIHUS FederalResearch GrantFY2025AbscissionAnteriorAtrialBackCardiac AtriumCardiac arteryCathetersCharacteristicsClinical EvaluationClinical TestingContracting OpportunitiesContractsCoronary arteryCoronary sinus structureDevelopmentDevicesDorsumElementsEmergenciesEmergency SituationEndocardiumEpicardiumExcisionExtirpationExtremitiesGoalsGuidelinesHeartHeart AtriumHeart arteryImplantImplantation procedureInterruptionInterventricular SeptumLeftLeft VentriclesLeft ventricular structureLimb structureLimbsMedicalMuscleMuscle TissueMyocardialMyocardiumNHLBINational Heart, Lung, and Blood InstituteNon-TrunkO elementO2 elementOxygenPace StimulatorsPacemakersPhaseProceduresRemovalRight VentriclesRight ventricular structureSBIRSiteSmall Business Innovation ResearchSmall Business Innovation Research GrantSpecific qualifier valueSpecifiedStructure of left gastric veinSurgical RemovalSurgical suturesSuturesSystemTechniquesVeinsVentricularVentricular septumWorkbasebasesbrain MR imagingbrain MRIbrain magnetic resonance imagingcardiac musclecardiac resynchronization therapycerebral MR imagingcerebral MRIcerebral magnetic resonance imagingclinical testcommercializationcoronary sinuscoronary veindevelopmentalheart muscleimplant placementimplant procedureimplantationinterstitialmuscularportabilityresearch clinical testingresectionrestrainttool
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Full Description

NHLBI has developed the Myocardial Intramural Restraint by endovenous interstitial teTHer (MIRTH) procedure and the related Suture via Coronary sinus with Interstitial myocardial navigation for MItral and Tricuspid Annular Reduction (SCIMITAR) procedure to accomplish single- and dual-valve annuloplasty via interstitial navigation of heart muscles entered through heart veins. Clinical evaluation will require the development of purpose-built MIRTH and SCIMITAR devices, which are similar. The contract aims to support the development and commercialization of transcatheter MIRTH and SCIMITAR system.

Grant Number: 75N92025C00010-0-9999-1
NIH Institute/Center: NIH
Principal Investigator: JOHN ALFORD

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