grant
SAVE-FistulaS: A Pivotal Study of SelfWrap-Assisted ArterioVEnous FistulaS
NIHUS FederalResearch GrantFY2026AV fistulaAbscissionAchievementAchievement AttainmentAddressAffectAmericanAnimal ModelAnimal Models and Related StudiesAortocoronary BypassArteriesArteriovenous AneurysmArteriovenous fistulaAwardBlindedBloodBlood Reticuloendothelial SystemBlood VesselsBlood flowBreakthrough deviceBypassCannulationsCardiovascularCardiovascular Body SystemCardiovascular DiseasesCardiovascular Organ SystemCardiovascular systemCathetersCell Growth in NumberCell MultiplicationCell ProliferationCellular ProliferationCessation of lifeChronicChronic Kidney FailureChronic Renal DiseaseChronic Renal FailureChronic kidney disease stage 5CirculationClinicalClinical ResearchClinical StudyCoronaryCoronary Artery BypassCoronary Artery Bypass GraftingCoronary Artery Bypass SurgeryCoronary arterial bypassDeathDeath RateDevicesDialysisDialysis patientsDialysis procedureDiseaseDisorderDomestic RabbitESKDESRDEffectivenessElasticityEnd stage renal failureEnd-Stage Kidney DiseaseEnd-Stage Renal DiseaseEndotheliumEnvironmentEventExcisionExposure toExtirpationFDA Device ApprovalFDA approvedFailureFeasibility StudiesFemaleFistulaFood and Drug Administration Device ApprovalFundingGeneralized GrowthGrowthHeart VascularHemodialysesHemodialysisHourHyperplasiaHyperplasticIRBIRBsInfectionInjuryInstitutional Review BoardsInterventionKidneyKidney Urinary SystemLeannessLength of LifeLifeLongevityMechanicsModelingMorbidityNational Institutes of HealthNeedlesOperative ProceduresOperative Surgical ProceduresOryctolagus cuniculusOvineOvisParticipantPatientsPeripheralPhasePhysiologicPhysiologicalPolymersRabbitsRabbits MammalsRandomizedRemovalSBIRSTTRSafetySepsisSheepSingle-Blind StudySingle-blindSmall Business Innovation ResearchSmall Business Innovation Research GrantSmall Business Technology Transfer ResearchStage 5 kidney failureStage 5 renal failureSurgicalSurgical InterventionsSurgical ProcedureSurgical RemovalThickThicknessThinnessTimeTissue GrowthToxinUnited StatesUnited States National Institutes of HealthVeinsVenousarmarteriovenous graftcardiovascular disorderchronic kidney diseasecirculatory systemcoronary bypassdialysis therapyeffectiveness outcomeeffectiveness-related outcomesimprovedinjuriesmalemechanicmechanicalmigrationmodel of animalmortalitymortality rateontogenypatient populationpolymerpolymericpre-clinicalpreclinicalpressureprimary outcomeprospectiverandomisationrandomizationrandomly assignedrenalresectionstandard of caresuccesssurgeryvascularvascular smooth muscle cell migrationvascular smooth muscle cell proliferation♀♂
Description preview
PROJECT SUMMARY/ABSTRACT
Arteriovenous fistulas (AVFs), surgical connections of autogenous arteries and veins, are considered the gold
standard for hemodialysis (HD), the primary mode of survival for half a million Americans with failed kidneys
(progressive chronic kidney disease, CKD) and millions more globally. However, 39% of the AVFs created…
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