RUI: Regulon identification for metalloregulatory transcription factors in the extremophile, Thermus thermophilus HB8

In all organisms, gene regulation is primarily controlled by transcription factors, proteins that bind DNA and influence gene expression (i.e., which genes are turned “on” or “off”). The activity of many transcription factors is controlled by environmental cues like nutrient availability, toxic substances, and heavy metals. As such, transcription…