grant
RPE Messengers, Transcription and Photoreceptor Renewal
Organization LSU HEALTH SCIENCES CENTERLocation NEW ORLEANS, UNITED STATESPosted 1 Mar 1984Deadline 30 Apr 2029
NIHUS FederalResearch GrantFY2025ACRP30 proteinAge related macular degenerationAge-Related MaculopathyAlzheimer beta-ProteinAlzheimer's Amyloid beta-ProteinAlzheimer's amyloidAmyloid Alzheimer's Dementia Amyloid ProteinAmyloid Beta-PeptideAmyloid Protein A4Amyloid beta-ProteinAmyloid βAmyloid β-PeptideAmyloid β-ProteinAutoregulationAβCell BodyCell Communication and SignalingCell FunctionCell Growth and MaintenanceCell LineCell MaintenanceCell PhysiologyCell ProcessCell SignalingCellLineCellsCellular FunctionCellular PhysiologyCellular ProcessCellular injuryDNA MethylationDevelopmentDocosahexaenoateDocosahexaenoic AcidsDocosahexenoic AcidsDown-RegulationDysfunctionEnvironmentEpigeneticEpigenetic ChangeEpigenetic MechanismEpigenetic ProcessEpithelial CellsEssential Fatty AcidsEyeEyeballFailureFamily memberFemaleFlecksFosteringFunctional disorderFundingFutureG-ProteinsGTP-Binding ProteinsGTP-Regulatory ProteinsGene ClusterGene ProteinsGene TranscriptionGenesGeneticGenetic TranscriptionGenomicsGoalsGrantGuanine Nucleotide Coupling ProteinGuanine Nucleotide Regulatory ProteinsHomeostasisHumanImpairmentInflammasomeInflammatoryIntermediary MetabolismIntracellular Communication and SignalingInvestigationKO miceKnock-outKnock-out MiceKnockoutKnockout MiceKnowledgeLightMediatingMediatorMembraneMetabolic ProcessesMetabolismMiceMice MammalsModern ManMolecularMurineMusNull MouseOutcomeOuter pigmented layer of retinaOxidative StressOxygen ConsumptionPathogenesisPathway interactionsPhotoradiationPhotoreceptor CellPhotoreceptorsPhotosensitive CellPhysiological HomeostasisPhysiopathologyPigment cell layer of retinaPigmented layer of retinaPolyunsaturated Fatty AcidsPredispositionProtein Gene ProductsProteinsPublishingRNA ExpressionReceptor ProteinRetinaRetinal DegenerationRetinal DiseasesRetinal DisorderRetinal Pigment EpitheliumRetinal pigment epithelial cellsRetinoic Acid AgentRetinoic Acid and DerivativesRetinoidsRodRods and ConesSignal PathwaySignal TransductionSignal Transduction SystemsSignalingStrains Cell LinesStructure of retinal pigment epitheliumSubcellular ProcessSusceptibilityTechnologyTelomeraseTestingTranscriptionTrxR1 enzymeVertebrate PhotoreceptorsVery Long Chain Fatty AcidVisual Receptora beta peptideabetaadipocyte complement-related protein 30-kDaadipocyte, C1q and collagen domain containing proteinadiponectinage dependent macular degenerationage induced macular degenerationage related macular diseaseage related macular dystrophyamyloid betaamyloid-b proteinapM-1 proteinapM1 (adipose-specific) proteinbeta amyloid fibrilbiological signal transductioncell damagecell injurycell resiliencecell resiliencycell typecellular damagecellular resiliencecellular resiliencyconditional knock-outconditional knockoutcultured cell linedamage to cellsdegenerative retina diseasesdevelopmentaldisease modeldisorder modelepigeneticallyepigenomicsexperimentexperimental researchexperimental studyexperimentshistone modificationinjury to cellslate-onset retinal degenerationlipid mediatormembrane structureneuroprotectin D1new therapeutic approachnew therapeutic interventionnew therapeutic strategiesnew therapy approachesnew treatment approachnew treatment strategynovel therapeutic approachnovel therapeutic interventionnovel therapeutic strategiesnovel therapy approachpathophysiologypathwayperoxidationphotoreceptor cell inner segmentprotein expressionreceptorreceptor-mediated signalingresponseretina degenerationretina diseaseretina disorderretinal degenerativeretinal degenerative diseasesretinopathysenescencesenescentsenile macular diseasesingle cell genomicssoluble amyloid precursor proteinspatial RNA sequencingspatial gene expression analysisspatial gene expression profilingspatial resolved transcriptome sequencingspatial transcriptome analysisspatial transcriptome profilingspatial transcriptome sequencingspatial transcriptomicsspatially resolved transcriptomicsspatio transcriptomicsthioredoxin reductase 1translational impactuptake♀
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Project Summary / Abstract
Despite their adverse environment, the question of how photoreceptor cells (PRC) and retinal pigment epithelial
cells (RPECs) are functionally unchanged for decades in healthy eyes remains to be answered. Studies
supported by this grant have defined the molecular cascade by which bioactive derivatives of the essential…
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