grant
ROS Signaling in Wound Healing vs Tissue Repair
Organization WESTERN MICHIGAN UNIVERSITYLocation KALAMAZOO, UNITED STATESPosted 1 May 2023Deadline 30 Apr 2027
NIHUS FederalResearch GrantFY2024ActinsActive OxygenAffectBody TissuesCell Communication and SignalingCell RespirationCell SignalingCellular RespirationCellular injuryCicatrixCloningDataDiabetes MellitusDiseaseDisorderFibrosisFosteringFutureGeneralized GrowthGenesGoalsGrowthHealthHost DefenseImmuneImmunesImmunohistochemistryImmunohistochemistry Cell/TissueImmunohistochemistry Staining MethodImpaired tissue repairImpaired wound healingIn Situ HybridizationInjuryIntracellular Communication and SignalingMalnutritionMediatingMicrosurgeryNatural regenerationNutritional DeficiencyO elementO2 elementObesityOperative ProceduresOperative Surgical ProceduresOrganismOutcomeOxygenOxygen RadicalsPatient outcomePatient-Centered OutcomesPatient-Focused OutcomesPlanariansPost-Transcriptional Gene SilencingPosttranscriptional Gene SilencingPro-OxidantsProcessProliferatingRNA InterferenceRNA SilencingRNAiReactive Oxygen SpeciesRegenerationRoleScarsSequence-Specific Posttranscriptional Gene SilencingSignal PathwaySignal TransductionSignal Transduction SystemsSignalingSiteSurgicalSurgical InterventionsSurgical ProcedureTechniquesTestingTissue GrowthTissuesTrainingUndernutritionWorkWound Repairabnormal tissue repairadiposityaerobic metabolismaerobic respirationbiological signal transductioncare costscell damagecell injurycellular damagechronic skin woundchronic woundcorpulencedamage to cellsdelayed wound healingdesigndesigningdiabetesdietary deficiencyfunctional restorationhealingin situ Hybridization Geneticsin situ Hybridization Staining Methodinjuriesinjury to cellsliving systemloss of functionmalnourishednutrition deficiencynutrition deficiency disordernutritional deficiency disorderontogenyoxidative metabolismpatient oriented outcomesrecruitregenerateregenerativerepairrepairedresponserestorationrestore functionrestore functionalityrestore lost functionsocial rolesurgerytissue repairtissue woundtobacco abuseundergradundergraduateundergraduate studentwoundwound healingwound recoverywound resolutionwound responsewoundingwounds
Description preview
Project Summary/Abstract
Proper wound healing is critical following surgery and injury, while compromised healing is a
factor in diseases such as diabetes, obesity, tobacco abuse, and malnutrition. As well, tissue
restoration after healing is limited, such that most repair leads to scar formation and loss of
function. With millions affected and…
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