grant
Roles of GATA Transcription Factors in Endometriosis
Organization NORTHWESTERN UNIVERSITYLocation CHICAGO, UNITED STATESPosted 5 Feb 2024Deadline 30 Nov 2028
NIHUS FederalResearch GrantFY20253-D3-Dimensional3DAddressAffectAreaAssayBasal Transcription FactorBasal transcription factor genesBioassayBiological AssayBlastocyst ImplantationBody TissuesCannot achieve a pregnancyCell BodyCell modelCellsCellular modelChromatinChronicClinicalComplexCorpus Luteum HormoneCoupledDNA MethylationDNA mutationDataDecidual Cell ReactionsDefectDelta4-pregnene-3,20-dioneDevelopmentDifficulty conceivingDiseaseDisorderDysfunctionEmberger syndromeEmbryo ImplantationEmotionalEndometrialEndometrial Stromal CellEndometriumEnhancersEnvironmentEpigeneticEpigenetic ChangeEpigenetic MechanismEpigenetic ProcessEpithelial CellsEpitheliumFamilyFemale Genital DiseasesFinancial HardshipFunctional disorderFutureGATA binding protein 4GATA-2 proteinGATA-6 proteinGATA-binding protein 2GATA2 deficiencyGATA2 haploinsufficiencyGATA2 transcription factorGATA4GATA4 geneGATA4 transcription factorGATA6 proteinGATA6 transcription factorGene ExpressionGene TranscriptionGeneral Transcription Factor GeneGeneral Transcription FactorsGenetic ChangeGenetic TranscriptionGenetic defectGenetic mutationGynecologic DiseasesHeterograftHeterologous TransplantationHumanInfertilityInflammationInflammatoryIslandKnowledgeMiceMice MammalsModelingModern ManMolecularMonoMACMurineMusMutationNF-E1b proteinNidationOrganOutcomeOvum ImplantationPathologicPatientsPelvicPelvic PainPelvic RegionPelvisPhenotypePhysiologicPhysiologicalPhysiopathologyPredictive ValuePregn-4-ene-3,20-dionePregnenedioneProcessProgesteroneRNA ExpressionResearchResistanceRetrograde MenstruationRoleSamplingSteroid CompoundSteroidsStromal CellsTestingTherapeutic InterventionTherapeutic ProgesteroneTissuesTranscriptionTranscription Factor Proto-OncogeneTranscription factor genesTravelUterine liningWomanWorkXenograftXenograft procedureXenotransplantationchildbearing agechronic pelvic floor painchronic pelvic painchronic pelvic pain syndromeclinical relevanceclinically relevantdecidualizationdevelopmentalembryo attachmentendometriosisepigeneticallyepigenomeepigenomicseutopic endometriumexperiencefertile agefertility cessationfertility lossfinancial adversityfinancial burdenfinancial distressfinancial insecurityfinancial strainfinancial stressgenome mutationgenome wide analysisgenome wide studiesgenome-wide analysisgenome-wide identificationglobal gene expressionglobal transcription profilehistone modificationin vivoinfertileinnovateinnovationinnovativeintervention therapymouse modelmurine modelnatural Blastocyst Implantationnew drug treatmentsnew drugsnew pharmacological therapeuticnew therapeuticsnew therapynext generation therapeuticsnovelnovel drug treatmentsnovel drugsnovel pharmaco-therapeuticnovel pharmacological therapeuticnovel therapeuticsnovel therapyoverexpressoverexpressionpathophysiologypelvic myofascial painprecision medicineprecision-based medicinepromoterpromotorreproductive agereproductive yearsresistantsocialsocial rolestemthree dimensionaltranscription factortranscription factor GATA-2transcription factor GATA-6transcriptometranscriptomicsxeno-transplantxeno-transplantation
Description preview
ABSTRACT
Endometriosis is associated with significant clinical, social, emotional, and financial burden on women and their
families. Endometriosis is a complex gynecologic disease affecting about 10% of women but remains poorly
understood at the molecular level. Endometriosis results from the establishment of ectopic islands of endometrial…
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