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Role of TOCA proteins in glia: from cellular morphology to animal behavior
Organization UNIVERSITY OF MIAMI SCHOOL OF MEDICINELocation CORAL GABLES, UNITED STATESPosted 1 Apr 2024Deadline 31 Mar 2026 ⚠️
NIHUS FederalResearch GrantFY2025ActinsAmino AcidsAnimal BehaviorBehavioral AssayBindingBinding ProteinsC elegansC. elegansC.elegansCDC42CDC42 Homolog GeneCDC42 geneCDC42-Interacting Protein GeneCDC42HsCIP4Caenorhabditis elegansCancer TreatmentCancersCausalityCell BodyCell FunctionCell LocomotionCell MigrationCell MobilityCell MovementCell PhysiologyCell ProcessCell ShapeCell membraneCellsCellular FunctionCellular MatrixCellular MigrationCellular MobilityCellular MorphologyCellular MotilityCellular PhysiologyCellular ProcessComplexConfocal MicroscopyCouplingCryo-electron MicroscopyCryoelectron MicroscopyCytoplasmic MembraneCytoskeletal SystemCytoskeletonDNA mutationDataDegenerative Neurologic DisordersDiseaseDisorderElectron CryomicroscopyEndocytosisEtiologyFamilyFluorescence Light MicroscopyFluorescence MicroscopyFoundationsFutureG25KG25K GeneGP GeneGTP PhosphohydrolasesGTPasesGeneHomologGenetic ChangeGenetic defectGenetic mutationGliaGlial CellsGoalsGuanosine Triphosphate PhosphohydrolasesGuanosinetriphosphatasesHealthHomologHomologous GeneHomologous ProteinHomologueHumanImageImmunodeficiency DisorderImmunodeficiency SyndromeImmunologic Deficiency SyndromesImmunological Deficiency SyndromesIn vivo analysisInvestigationInvestigatorsKnowledgeKolliker's reticulumLengthLigand Binding ProteinLigand Binding Protein GeneMalignant Neoplasm TherapyMalignant Neoplasm TreatmentMalignant NeoplasmsMalignant TumorMembraneMembrane BiologyMembrane Protein GeneMembrane ProteinsMembrane-Associated ProteinsMethodsModelingModern ManMolecular ConfigurationMolecular ConformationMolecular InteractionMolecular StereochemistryMonomeric G-ProteinsMonomeric GTP-Binding ProteinsMorphologyMotilityMutationNerve DegenerationNervous System Degenerative DiseasesNervous System PhysiologyNeural Degenerative DiseasesNeural degenerative DisordersNeurodegenerative DiseasesNeurodegenerative DisordersNeurodevelopmental DisorderNeurogliaNeuroglial CellsNeurologic Degenerative ConditionsNeurologic functionNeurological Development DisorderNeurological functionNeuron DegenerationNon-neuronal cellNonneuronal cellOrganellesOrganismPeripheralPhenotypePhysiologicPhysiologicalPlasma MembranePolymersPositionPositioning AttributeProcessProtein BindingProtein FamilyProtein HomologProteinHomologProteinsResearch PersonnelResearchersResolutionRoleSamplingSensorySmall G-ProteinsSmall GTPasesStructureSubcellular ProcessSurface ProteinsTRIP10TRIP10 geneTechniquesTestingThyroid Hormone Receptor Interactor 10 GeneWorkYeastsaminoacidamphiphysinanti-cancer therapybound proteincancer therapycancer-directed therapycausationcell morphologycell motilityconformationconformationalconformational stateconformationallyconformationscryo-EMcryoEMcryogenic electron microscopydegenerative diseases of motor and sensory neuronsdegenerative neurological diseasesdesigndesigningdevelopmental diseasedevelopmental disorderdisease causationexperiencegenome mutationguanosinetriphosphataseimagingimmune deficiency disorderin vivoin vivo Modelin vivo evaluationin vivo testingintracellular skeletonknock-downknockdownliving systemmalignancymembrane structurenanoneoplasm/cancernerve cementnervous system functionneural degenerationneurodegenerationneurodegenerativeneurodegenerative illnessneurodevelopmental diseaseneurological degenerationneuronal degenerationnovelplasmalemmapolymerpolymericpolymerizationprotein functionprotein structureprotein structuresproteins structurerecruitresolutionsresponserho G-Proteinsrho GTP-Binding Proteinsrho GTPasesrho Protein P21rho Small GTP-Binding Proteinssocial rolestructural biologytargeted drug therapytargeted drug treatmentstargeted therapeutictargeted therapeutic agentstargeted therapytargeted treatment
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Description preview
SUMMARY
Cells use a broad arsenal of proteins to change the curvature of cell membranes. This is important for cell motility,
endocytosis, and establishment of cell morphology. As such, it comes as no surprise that components of this
machinery are central in the etiology of many diseases, including developmental and immunodeficiency
disorders,…
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