grant
Role of the BLA-Insula circuit in stress-induced aversive drinking and negative affective states
Organization WAKE FOREST UNIVERSITY HEALTH SCIENCESLocation WINSTON-SALEM, UNITED STATESPosted 15 Sept 2025Deadline 14 Sept 2028
NIHUS FederalResearch GrantFY2025AbstinenceAffectAffectiveAffective DisordersAgeAlcohol Chemical ClassAlcohol DrinkingAlcohol abuseAlcohol consumptionAlcohol dependenceAlcohol withdrawal syndromeAlcoholsAmericanAmygdalaAmygdaloid BodyAmygdaloid NucleusAmygdaloid structureAnimal ModelAnimal Models and Related StudiesAnxietyAreaAutomobile DrivingBehaviorBehavior assessmentBehavior-Related DisorderBehavior-Related ProblemBiological MarkersBrainBrain Nervous SystemCalciumCell BodyCellsCentral LobeClinical ResearchClinical StudyComplementComplement ProteinsComprehensionConsumptionCoping BehaviorCorticosteroneCuesDarknessDevelopmentDiagnosisDiagnosticDysfunctionEmotionalEmotionsEncephalonEtOH abuseEtOH drinkingEtOH useFiberFunctional disorderGeneticHPA axisHyperactivityIndividualIndividual DifferencesInsulaInsula of ReilInterventionIsland of ReilKI miceKnock-in MouseKnowledgeLifestyle-Related DisorderLifestyle-Related ProblemLifestyle-related conditionLightMaintenanceMajor Depressive DisorderMeasuresMental disordersMental health disordersMicroscopyMood DisordersNerve CellsNerve UnitNeural CellNeurocyteNeuronsOutputPTSDPathway interactionsPatientsPatternPersonsPhenotypePhotometryPhotoradiationPhysiologicPhysiologicalPhysiopathologyPlayPopulationPost-Traumatic NeurosesPost-Traumatic Stress DisordersPosttraumatic NeurosesPre-Clinical ModelPreclinical ModelsProbabilityPsychiatric DiseasePsychiatric DisorderPublic HealthRisk FactorsRoleSeveritiesSocietiesStressStress and CopingSymptomsTechniquesTestingUnited StatesViralWorkabstaining from alcoholabstaining from ethanolabstinence from alcoholabstinence from ethanolagesalcohol abstinencealcohol addictionalcohol behavioralcohol co-abusealcohol dependencyalcohol dependentalcohol induced behavioralcohol ingestionalcohol intakealcohol problemalcohol product usealcohol related behavioralcohol usealcohol use disorderalcohol withdrawalalcoholic beverage consumptionalcoholic drink intakeamygdaloid nuclear complexanxiety-like behaviorbehavioral assessmentbio-markersbiologic markerbiological adaptation to stressbiomarkerclinical depressionco-morbidco-morbiditycognitive controlcomorbiditycomplementationconditioned fearcoping with stresscostdevelopmentaldrinkingdrinking behaviordrivingethanol abstinenceethanol abuseethanol behaviorethanol consumptionethanol drinkingethanol induced behaviorethanol ingestionethanol intakeethanol product useethanol related behaviorethanol useethanol use disorderethanol withdrawalfear conditioninghazardous alcohol usehuman imaginghypothalamic-pituitary-adrenal (HPA) axishypothalamic-pituitary-adrenal axishypothalmus-pituitary-adrenal axisimaging studyin vivoinsightinterestknockin micemajor depressionmajor depression disordermental illnessmodel of animalmouse modelmurine modelnegative affectnegative affectivitynegative emotional stateneuralneural circuitneural circuitryneurocircuitryneuronalpathophysiologypathwaypost-trauma stress disorderposttrauma stress disorderpre-clinical studypreclinical studyproblem alcohol useproblem drinkingproblematic alcohol consumptionproblematic alcohol usepsychiatric illnesspsychological disorderreaction; crisisrecruitsocial rolestress disorderstress related disorderstress responsestress-related copingstress; reactionstressorsynaptic circuitsynaptic circuitrytraumatic neurosistraumatic stresswithdrawal from alcohol
Description preview
PROJECT SUMMARY
In 2023, Alcohol Use Disorder (AUD) affected an estimated 28.9 million people, about 10.5% of the American
population ages 12 and older. AUD has consistently been a public health crisis for many decades, costing the
US economy $249 billion in 2010. The current treatments available are not effective, further warranting
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