grant
Role of T-bet B cells in rheumatoid arthritis
Organization UNIVERSITY OF ROCHESTERLocation ROCHESTER, UNITED STATESPosted 12 Dec 2023Deadline 31 Oct 2028
NIHUS FederalResearch GrantFY2025(TNF)-αAbnormal CellAccelerationAffectAnimal ModelAnimal Models and Related StudiesArthritisAtrophic ArthritisAutomobile DrivingB blood cellsB cellB cellsB-Cell DevelopmentB-Cell SubsetsB-CellsB-Lymphocyte SubsetsB-LymphocytesB-cellBloodBlood Reticuloendothelial SystemBlood monocyteBody TissuesBone FormationCCL3CCL3 geneCD150CD150 antigenCD183CDw150 proteinCKR-L2CMKAR3CXC chemokine receptor 3CXCL9CXCL9 geneCXCR3CXCR3 geneCXCR3 proteinCXCR3 receptorCachectinCell BodyCell FunctionCell LineageCell LocomotionCell MigrationCell MovementCell PhysiologyCell ProcessCellsCellular FunctionCellular MigrationCellular MotilityCellular PhysiologyCellular ProcessCellular injuryChemokine (C-C motif) Ligand 3Chemokine (C-X-C Motif) Receptor 3Chemokine Receptor GeneChemotactic CytokinesChronicClinicalCo-cultureCocultivationCocultureCoculture TechniquesCohort StudiesCollagen ArthritisCollagen-Induced ArthritisConcurrent StudiesDataDiseaseDisease remissionDisorderEffector CellFamily memberFutureG Protein-Coupled Receptor 9G0S19-1GPR9Gene TranscriptionGenetic TranscriptionGenomic approachGoalsHomologous Chemotactic CytokinesHumigIFNIP10IP10 ReceptorIP10-Mig receptorIP10-RImmuneImmunesIn VitroInflammationInflammatoryInflammatory ResponseIntercrinesInterferonsJoint DiseasesJointsKO miceKineticsKnock-outKnock-out MiceKnockoutKnockout MiceKnowledgeLD78ALPHALigandsLinkLocationLong-term cohortLongitudinal cohortLupusLupus Erythematosus DisseminatusMIG GeneMIP 1alphaMIP-1-alphaMIP-1aMIP1AMacrophage-Derived TNFMarrow monocyteMediatingMedicineMembrana Synovialis Capsulae ArticularisMiceMice MammalsMig ReceptorMig-RMigRModelingMonocyte-Derived TNFMorbidityMorbidity - disease rateMurineMusNational Institutes of HealthNull MouseOPGLOsteoblastsOsteoclastsOsteogenesisPathogenesisPathogenicityPathogenicity FactorsPatientsPhenotypePopulationProductionRANKLRNA ExpressionRegulationRemissionReporterReportingResearchResolutionRheumatoid ArthritisRoleSCYA3SCYB9SIS cytokinesSLAM proteinSLESeverity of illnessSmall Inducible Cytokine A3Stem Cell InhibitorSubcellular ProcessSynovial MembraneSynovitisSynoviumSystemic Lupus ErythematosusSystemic Lupus ErythematousSystemic Lupus ErythmatosusT-CellsT-LymphocyteT-bet proteinT-bet transcription factorTNFTNF ATNF AlphaTNF geneTNF-αTNFATNFSF11TNFSF11 geneTNFαTherapeuticTimeTissuesTranscriptionTumor Necrosis FactorTumor Necrosis Factor-alphaUnited States National Institutes of HealthVirulence Factorsaggressive therapyaggressive treatmentarthriticarthropathicarthropathiesarthropathyautoimmune reactivityautoreactivitybonebone erosionbone tissue formationcell damagecell injurycell motilitycellular damagechemoattractant cytokinechemokinechemokine receptorclinical remissioncohortcrg-10customized therapycustomized treatmentcytokinedamage to cellsdefined contributiondisabilitydisease severitydisseminated lupus erythematosusdrivinggenomic effortgenomic strategyhRANKL2improved outcomeindividualized medicineindividualized patient treatmentindividualized therapeutic strategyindividualized therapyindividualized treatmentinflamed jointinflamed synovial tissueinflamed synoviuminjury to cellsinnovateinnovationinnovativejoint damagejoint degenerationjoint degradationjoint destructionjoint disorderjoint inflammationjoint injuryjoint swellingjoint tissue degenerationjoint traumamigrationmodel of animalmonocytemortalitynew drug treatmentsnew drugsnew pharmacological therapeuticnew therapeuticsnew therapynext generation therapeuticsnovelnovel drug treatmentsnovel drugsnovel pharmaco-therapeuticnovel pharmacological therapeuticnovel therapeuticsnovel therapypathogenicity genepatient specific therapiespatient specific treatmentpre-clinicalpre-clinical studypreclinicalpreclinical studypreventpreventingprogramsresolutionsresponserheumatic arthritisrole modelsOdfscRNA sequencingscRNA-seqsignaling lymphocytic activation moleculesignaling lympocyte activation moleculesingle cell RNA-seqsingle cell RNAseqsingle cell expression profilingsingle cell transcriptomic profilingsingle-cell RNA sequencingsocial rolesynovial inflammationsystemic lupus erythematosistailored medical treatmenttailored therapytailored treatmentthymus derived lymphocytetranscriptomicstranslational studytreatment strategyunique treatmentvirulence genevirulent gene
Description preview
Although new treatments have improved outcomes in rheumatoid arthritis (RA), disability remains
high, most patients have ongoing disease activity, and lasting remissions are rare. A major gap
in the field is the elusive identity of pathogenic cells driving persistent inflammation and bone
erosion. Our lab focuses on the identification of…
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