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Role of SUN1 in MASLD and metabolic disease
Organization UNIVERSITY OF MICHIGAN AT ANN ARBORLocation ANN ARBOR, UNITED STATESPosted 1 Apr 2024Deadline 31 Mar 2026 ⚠️
NIHUS FederalResearch GrantFY202521+ years oldAdipocytesAdipose CellAdipose tissueAdultAdult HumanAffectAreaAutomobile DrivingAutoregulationBiochemicalBody TissuesCell BodyCell LineCellLineCellsCellular MatrixChargeChromatinCirrhosisCodeCoding SystemComplexCytoskeletal SystemCytoskeletonDataData DiscoveryData SetDefectDevelopmentDiseaseDisorderDysfunctionFat CellsFatty LiverFatty TissueFunctional disorderFundingGene FrequencyGene TranscriptionGene variantGenesGeneticGenetic TranscriptionGenomeGenomicsGoalsHIV Lipodystrophy SyndromeHIV-Associated LipodystrophyHIV-Associated Lipodystrophy SyndromeHepatic CellsHepatic DisorderHepatic Parenchymal CellHepatic TransplantationHepatocyteHistologicHistologicallyHomeostasisHuman GeneticsIncidenceIndividualInsulin ResistanceLaboratoriesLamin ALamin Type ALinkLipidsLipocytesLipodystrophyLipodystrophy SyndromeLiverLiver CellsLiver GraftingLiver SteatosisLiver TransplantLiver diseasesMature LipocyteMature fat cellMedicalMembrane Protein GeneMembrane ProteinsMembrane-Associated ProteinsMetabolicMetabolic DiseasesMetabolic DisorderMetabolic PathwayMetabolic dysfunctionMichiganMinorMorbidityMorbidity - disease rateNAFLDNIDDKNational Institute of Diabetes and Digestive and Kidney DiseasesNuclear EnvelopeNuclear Inner MembraneNuclear LaminaNuclear MembraneNucleoplasmObesity associated liver diseaseObesity related liver diseaseParticipantPathway interactionsPersonsPhysiological HomeostasisPhysiopathologyPlayPopulationProteinsRNA ExpressionRNA TransportRibonucleic Acid TransportRoleSiblingsSteatohepatitisStrains Cell LinesStructureSurface ProteinsTechniquesTestingTherapeuticThesaurismosisTissuesTranscriptionTransfectionTwin Multiple BirthTwinsUnited StatesValidationVariantVariationWorkadiposeadulthoodallelic frequencyallelic variantbiobankbiorepositorycell typechronic hepatic diseasechronic hepatic disorderchronic liver diseasechronic liver disordercirrhoticcohortcultured cell linedevelopmentaldrivingearly onseteffective therapyeffective treatmentexomefat metabolismgenetic variantgenomic varianthepatic body systemhepatic diseasehepatic organ systemhepatic steatosishepatoma cellhepatopathyhepatosteatosisin vitro Modelin vivoinsulin resistantinsulin sensitivityinsulin toleranceintracellular skeletonlarge data setslarge datasetslipid metabolismliver disorderliver transplantationlow-frequency mutationmetabolism disordermortalitymouse modelmurine modelnew drug targetnew drug treatmentsnew druggable targetnew drugsnew pharmacological therapeuticnew pharmacotherapy targetnew therapeutic targetnew therapeuticsnew therapynew therapy targetnext generation therapeuticsnon-alcohol fatty liver diseasenon-alcoholic fatty liver diseasenon-alcoholic liver diseasenonalcoholic fatty liver diseasenovelnovel drug targetnovel drug treatmentsnovel druggable targetnovel drugsnovel pharmaco-therapeuticnovel pharmacological therapeuticnovel pharmacotherapy targetnovel therapeutic targetnovel therapeuticsnovel therapynovel therapy targetobesity geneticspathophysiologypathwayprotective effectrare allelerare mutationrare variantsocial roletargeted drug therapytargeted drug treatmentstargeted therapeutictargeted therapeutic agentstargeted therapytargeted treatmenttherapeutic targettraitvalidationswhite adipose tissueyellow adipose tissue
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Description preview
Metabolic dysfunction-associated steatotic liver disease (MASLD), previously termed nonalcoholic fatty liver
disease (NAFLD), is the most common chronic liver disease in the United States and a rapidly growing cause
of morbidity, mortality, and need for liver transplantation. Therefore, there is a critical need for effective
therapies for this…
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