grant
Role of RIPK2 in the neuroinflammatory response to ischemic stroke
Organization UNIVERSITY OF FLORIDALocation GAINESVILLE, UNITED STATESPosted 1 Jun 2023Deadline 31 May 2028
NIHUS FederalResearch GrantFY202521+ years oldAblationAbscissionAcquired brain injuryAcuteAddressAdultAdult HumanAlteplaseAmentiaAnimal ModelAnimal Models and Related StudiesAnimalsApoplexyApoptosisApoptosis PathwayAttenuatedBBB permeabilizationBBB permeableBasic ResearchBasic ScienceBenzamidesBlood monocyteBrainBrain InjuriesBrain IschemiaBrain Nervous SystemBrain Vascular AccidentCARD-Containing IL-1 Beta Ice-KinaseCARD-Containing Interleukin-1 Beta Converting Enzyme Associated KinaseCARD-containing interleukin -1 beta converting enzymeCARD3CARDIAKCRE RecombinaseCRISPR approachCRISPR based approachCRISPR methodCRISPR methodologyCRISPR techniqueCRISPR technologyCRISPR toolsCRISPR-CAS-9CRISPR-based methodCRISPR-based techniqueCRISPR-based technologyCRISPR-based toolCRISPR/CAS approachCRISPR/Cas methodCRISPR/Cas technologyCRISPR/Cas9CRISPR/Cas9 technologyCas nuclease technologyCause of DeathCell BodyCell Communication and SignalingCell DeathCell LineageCell SignalingCellsCerebral StrokeCerebrovascular ApoplexyCerebrovascular StrokeChemotactic CytokinesChronicClottingClustered Regularly Interspaced Short Palindromic Repeats approachClustered Regularly Interspaced Short Palindromic Repeats methodClustered Regularly Interspaced Short Palindromic Repeats methodologyClustered Regularly Interspaced Short Palindromic Repeats techniqueClustered Regularly Interspaced Short Palindromic Repeats technologyCoagulationCoagulation ProcessDataDementiaDendritic CellsDiabetes MellitusDoseDrug TherapyEncephalonEnterobacteria phage P1 Cre recombinaseExcisionExonsExtirpationFinancial HardshipFlow CytofluorometriesFlow CytofluorometryFlow CytometryFlow MicrofluorimetryFlow MicrofluorometryFoundationsGoalsHealth Care SystemsHomologous Chemotactic CytokinesHortega cellHourImmuneImmune infiltratesImmunesImmunoassayImmunoblottingImpairmentIndustryInfarctionInfiltrationInflammationInflammation MediatorsInflammatoryInjuryIntercrinesInterventionIntracellular Communication and SignalingInvadedIschemiaIschemic Brain InjuryIschemic EncephalopathyIschemic PenumbraIschemic StrokeKO miceKinasesKnock-out MiceKnockout MiceKnowledgeLabelLifelong disabilityLoxP-flanked alleleMR ImagingMR TomographyMRIMRIsMacrophageMagnetic Resonance ImagingMarrow monocyteMeasuresMechanicsMedical Imaging, Magnetic Resonance / Nuclear Magnetic ResonanceMiceMice MammalsMicrogliaMissionModelingMolecularMouse StrainsMurineMusMyelogenousMyeloidMyeloid CellsMφNINDSNMR ImagingNMR TomographyNational Institute of Neurological Diseases and StrokeNational Institute of Neurological Disorders and StrokeNerve CellsNerve UnitNervous System DiseasesNervous System DisorderNeural CellNeurocyteNeurologicNeurologic DeficitNeurologic DisordersNeurologicalNeurological DisordersNeuronsNeuroprotectantsNeuroprotective AgentsNeuroprotective DrugsNuclear Magnetic Resonance ImagingNull MouseObesityOutcomePathologyPathway interactionsPatientsPatternPeripheralPermanent disabilityPharmacological TreatmentPharmacotherapyPhasePhenotypePhosphotransferase GenePhosphotransferasesProcessProductionProgrammed Cell DeathProtacProteinsProteolysis targeting chimericPublic HealthRICK proteinRIP-Like Interacting CLARP KinaseRIP2RIPK2RIPK2 geneRIPK2 proteinReceptor InhibitionReceptor-Interacting Protein 2Receptor-Interacting Serine/Threonine Protein Kinase 2Recombinant Tissue Plasminogen ActivatorRemovalReperfusion TherapyResearchRoleSIS cytokinesSensorimotor functionsSignal TransductionSignal Transduction SystemsSignalingSiteStrokeSurgical RemovalT-Plasminogen ActivatorTamoxifenTechnologyTherapeuticThrombectomyTimeTissue Activator D-44Tissue Plasminogen ActivatorTissue-Type Plasminogen ActivatorTracerTransphosphorylasesVeiled CellsWestern BlottingWestern ImmunoblottingWild Type MouseZeugmatographyadiposityadulthoodafter strokeaged miceaged mouseaged rodentaged rodentsattenuateattenuatesbacteriophage P1 recombinase Crebehavior outcomebehavioral outcomebiological signal transductionblood-brain barrier permeabilizationblood-brain barrier permeablebloodbrain barrier permeabilizationbloodbrain barrier permeablebrain attackbrain damagebrain-injuredcell typecerebral vascular accidentcerebrovascular accidentchemoattractant cytokinechemokineclinical relevanceclinically relevantco-morbidco-morbiditycognitive functioncomorbiditycorpulencecytokinediabetesdrug interventiondrug treatmentelderly miceelderly rodentfinancial adversityfinancial burdenfinancial distressfinancial insecurityfinancial strainfinancial stressflow cytophotometryfloxedfloxed allelefunctional outcomesgenome editinggenomic editinggitter cellglial activationglial cell activationimmune cell infiltrateimprovedimproved outcomein vivoinfarctinflammatory mediatorinhibitorinjuriesinnovateinnovationinnovativeischemic brain damagekinase inhibitormechanicmechanicalmesogliamicroglial cellmicrogliocytemodel of animalmonocytenanostringnecrocytosisneural inflammationneuroinflammationneuroinflammatoryneurological diseaseneurological recoveryneuronalneuronal survivalneuroprotectionneuroprotectivenew drug classnew drug targetnew druggable targetnew pharmacotherapy targetnew therapeutic targetnew therapy targetnovelnovel drug classnovel drug targetnovel druggable targetnovel pharmacotherapy targetnovel therapeutic targetnovel therapy targetold miceold rodentpathwayperivascular glial cellpharmaceutical interventionpharmacologicpharmacological interventionpharmacological therapypharmacology interventionpharmacology treatmentpharmacotherapeuticspost strokepoststrokeprotein blottingproteolysis targeting chimaeraproteolysis targeting chimerareceptor-interacting serine-threonine kinase 2recruitreperfusionresectionresponsesexsocial rolestroke modelstroke outcomestroke patientstroke therapystroke treatmentstrokedstrokessuccesst-PAthrombolysistooltreating strokewildtype mouse
Description preview
Abstract
Neuroinflammation after stroke significantly contributes to neuronal damage and neurological impairment.
Delayed cell death in the ischemic penumbra is associated with glial activation and recruitment and infiltration of
peripheral immune cells to the brain. This is triggered by the production of pro-inflammatory cytokines and…
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