grant
Role of peroxisome-mitochondrion communication in tissue aging
NIHUS FederalResearch GrantFY2025Active OxygenAgeAge related pathologiesAgingAnabolismAnimalsAreaAssayAttenuatedAutoregulationBindingBinding ProteinsBioassayBiological AssayBody TissuesCRISPRCRISPR/Cas systemCell AgingCell BodyCell SenescenceCellsCellular AgingCellular SenescenceClustered Regularly Interspaced Short Palindromic RepeatsCommunicationDrosophilaDrosophila genusDysfunctionEnzyme GeneEnzymesEther PhosphatidatesFeedbackFunctional disorderGene TranscriptionGenetic TranscriptionGlycerol Phosphate EthersGlycerophosphate EthersGoalsHealthHepatic CellsHepatic Parenchymal CellHepatocyteHomeostasisImaging DeviceImaging InstrumentImaging ToolImpairmentIncrease lifespanIntermediary MetabolismInterventionKinasesLength of LifeLigand Binding ProteinLigand Binding Protein GeneLipidsLiver CellsLongevityMediatingMetabolicMetabolic ProcessesMetabolismMitochondriaMolecular InteractionMonoubiquitinationMorphologyOrganellesOxidation-ReductionOxidative StressOxygen RadicalsPTS1 receptorPXR1 proteinPathway interactionsPex5 proteinPhospholipid EthersPhosphorylationPhosphotransferase GenePhosphotransferasesPhysiological HomeostasisPhysiopathologyPlasmalogensPlayPro-OxidantsProtein BindingProtein ImportProtein PhosphorylationProteinsProteomicsRNA ExpressionReactive Oxygen SpeciesReceptor ProteinRecyclingRedoxRegulationReplicative SenescenceResearchRoleSiteStressStructureTestingTissuesTranscriptionTranscriptional ControlTranscriptional RegulationTransphosphorylasesUbiquitin Ligase Component GeneUbiquitin Ligase GeneUpregulationVery Long Chain Fatty AcidWorkage associatedage associated alterationsage associated changesage associated declineage associated diseaseage associated disorderage associated impairmentage associated pathologiesage correlatedage correlated alterationsage correlated changesage dependentage dependent alterationsage dependent changesage dependent declineage dependent diseaseage dependent disorderage dependent impairmentage dependent pathologiesage induced alterationsage induced changesage induced pathologiesage linkedage relatedage related alterationsage related changesage related declineage related human diseaseage specificage specific alterationsage specific changesage-related diseaseage-related disorderage-related impairmentagesaging associated alterationsaging associated changesaging associated pathologiesaging correlated alterationsaging correlated changesaging dependent alterationsaging dependent changesaging dependent pathologiesaging induced alterationsaging induced changesaging induced pathologiesaging pathologiesaging related alterationsaging related changesaging related pathologiesaging specific alterationsaging specific changesalterations with ageattenuateattenuatesbiological adaptation to stressbiosynthesisboost longevitybound proteinchanges with agedecline with ageelongating the lifespanenhance longevityextend life spanextend lifespanextend longevityfat metabolismfoster longevityfruit flyfusion genegene manipulationgenetic manipulationgenetically manipulategenetically perturbgenome editinggenomic editingimprove lifespanimprove longevityinsightinterdisciplinary approachlifespan extensionlipid metabolismmetabolism measurementmetabolomicsmetabonomicsmitochondrialmultidisciplinary approachnovelold ageoverexpressoverexpressionoxidationoxidation reduction reactionpathophysiologypathwayperoxin PEX5peroxisomepreservationprolong lifespanprolong longevitypromote lifespanpromote longevityreaction; crisisreceptorrecruitrepairrepairedreplicative agingsocial rolestress responsestress; reactionsupport longevityubiquitin ligase
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Project Summary/Abstract
Inter-organelle communication plays an essential role in maintaining cellular homeostasis
and animal aging. Mitochondria, as a highly dynamic organelle and the metabolic hub of the cell,
frequently interact with other cellular organelles to coordinate metabolic processes and maintain
cellular homeostasis. Although it is…
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