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Role of nucleus accumbens core in ethanol reward and binge-like drinking: Focus on sex as a biological variable
Organization OREGON HEALTH & SCIENCE UNIVERSITYLocation PORTLAND, UNITED STATESPosted 9 May 2023Deadline 27 Jun 2025 ⚠️
NIHUS FederalResearch GrantFY2025Absolute ethanolAbstinenceAddressAlcohol Chemical ClassAlcohol DrinkingAlcohol IntoxicationAlcohol consumptionAlcoholic IntoxicationAlcoholsAmmon HornAmygdalaAmygdaloid BodyAmygdaloid NucleusAmygdaloid structureAnatomic SitesAnatomic structuresAnatomyAnesthesiaAnesthesia proceduresAssayBehaviorBilateralBioassayBiological AssayBiological MarkersBloodBlood Reticuloendothelial SystemBlood SampleBlood specimenBrainBrain Nervous SystemBrain imagingBrain regionCentral LobeClozapineCornu AmmonisCuesDREADDsDarknessDeep Brain StimulationDendritic SpinesDiagnosisDifferences between sexesDiffers between sexesDoseDrunkennessETOHEncephalonEtOH drinkingEtOH intoxicationEtOH useEthanolEthyl AlcoholFBJ osteosarcoma oncogeneFOS geneFemaleG0S7Gene TranscriptionGeneticGenetic TranscriptionGlobus PallidusGrain AlcoholHippocampusHumanHydrogen OxideHypothalamic structureHypothalamusImageInjectionsInsulaInsula of ReilIntakeInterventionIntoxicationIsland of ReilLabelLesionLifeLightLiquid substanceMeasuresMethylcarbinolMiceMice MammalsModern ManMolecularMurineMusNerve CellsNerve UnitNeural CellNeurocyteNeuronsNucleus AccumbensOxidesPatientsPerfusionPhotoradiationProtooncogene FOSRNA ExpressionResearchResistanceRewardsRisk FactorsRodentRodent ModelRodentiaRodents MammalsRoleSalineSaline SolutionSex DifferencesSexual differencesSpinal ColumnSpineSynapsinsTactileTechnologyTestingTimeTracerTranscriptionVentral StriatumVertebral columnViralVirusVisualWaterWomanWorkabstaining from alcoholabstaining from ethanolabstinence from alcoholabstinence from ethanolabused drugabused drugsalcohol abstinencealcohol abuse therapyalcohol abuse treatmentalcohol cravingalcohol effectalcohol ingestionalcohol intakealcohol product usealcohol responsealcohol rewardalcohol treatmentalcohol usealcohol use disorderalcoholic beverage consumptionalcoholic drink intakeamygdaloid nuclear complexbackbonebio-markersbiologic markerbiological sex as a modifierbiomarkerbrain visualizationc fosc-fos Genec-fos Proto-Oncogenesconditioned place preferenceconditioningdendrite spinedensitydesigner receptors exclusively activated by designer drugsdrinkingdrug abuseddrug of abusedrugs abuseddrugs of abuseethanol abstinenceethanol consumptionethanol cravingethanol drinkingethanol effectethanol ingestionethanol intakeethanol intoxicationethanol product useethanol responseethanol rewardethanol useethanol use disorderexperimental groupfluidgene manipulationgenetic manipulationgenetically manipulategenetically perturbhippocampalhuman modelhypothalamicimagingimprovedliquidmalemenmicroscope imagingmicroscopic imagingmicroscopy imagingmodel of humanmouse modelmurine modelneural circuitneural circuitryneural networkneurocircuitryneuronalpallidumplace conditioningpreventpreventingpromoterpromotorresistantresponseresponse to alcoholresponse to ethanolsexsex as a biological factorsex as a biological measuresex as a biological risk factorsex as a biological variablesex as a biological variancesex as a biologically significant variablesex as a fundamental variablesex based differencessex-dependent differencessex-related differencessex-specific differencessocial rolesynaptic circuitsynaptic circuitrytherapeutic candidatev-FOS FBJ Murine Osteosarcoma Viral Oncogene Homolog♀♂
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Description preview
Project Summary
Binge alcohol drinking is a risk factor for Alcohol Use Disorder (AUD), and while alcohol use and AUD
diagnoses are more prevalent in men than women, this gap has drastically narrowed. Promising therapeutic
candidates for the treatment of AUD have been identified using rodent models; however, few studies have
addressed sex as a…
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