grant
Role of NFKBIA Deficiency in Subverting Neural Progenitor Commitment Toward Gliomagenesis
Organization UNIVERSITY OF MIAMI SCHOOL OF MEDICINELocation CORAL GABLES, UNITED STATESPosted 21 Aug 2025Deadline 31 Jul 2030
NIHUS FederalResearch GrantFY20253-D3-Dimensional3DArchitectureAutomobile DrivingBasic Mechanisms of SUMOylationBindingBiologyBrainBrain NeoplasiaBrain NeoplasmsBrain Nervous SystemBrain TumorsCRISPR approachCRISPR based approachCRISPR methodCRISPR methodologyCRISPR techniqueCRISPR technologyCRISPR toolsCRISPR-CAS-9CRISPR-based methodCRISPR-based techniqueCRISPR-based technologyCRISPR-based toolCRISPR/CAS approachCRISPR/Cas methodCRISPR/Cas technologyCRISPR/Cas9CRISPR/Cas9 technologyCas nuclease technologyCell BodyCell DifferentiationCell Differentiation processCellsChildhoodChildhood GliomaChromatinChromatin Remodeling ComplexChromatin Remodeling FactorClustered Regularly Interspaced Short Palindromic Repeats approachClustered Regularly Interspaced Short Palindromic Repeats methodClustered Regularly Interspaced Short Palindromic Repeats methodologyClustered Regularly Interspaced Short Palindromic Repeats techniqueClustered Regularly Interspaced Short Palindromic Repeats technologyComplexDNADNA mutationDataDeoxyribonucleic AcidDepositDepositionDevelopmentDevelopmental GeneDifferentiated GeneDiffuseDiseaseDisorderEGFRvIIIENX-1EZH1EZH2EZH2 geneEncephalonEngineering / ArchitectureEnhancer of Zeste 2 Polycomb Repressive Complex 2 SubunitGene InactivationGene OrganizationGene SilencingGene StructureGene Structure/OrganizationGene TranscriptionGeneticGenetic ChangeGenetic TranscriptionGenetic defectGenetic mutationGenomeGenotypeGlial Cell TumorsGlial NeoplasmGlial TumorGlioblastomaGliomaGliomagenesisGrade IV Astrocytic NeoplasmGrade IV Astrocytic TumorGrade IV AstrocytomaH3 K27M mutantH3 K27M mutationH3K27M mutantH3K27M mutationHeterozygoteHistone H2AHistone H3Histone H4HistonesI Kappa B AI Kappa B-AlphaI kappa B-alpha proteinIKB-AlphaIKBAIKappaBIKappaB-AlphaIKappaB/MAD-3IkappaBalphaIκBαKMT6KMT6AKnowledgeL-LysineLysineMAD-3MAD-3 proteinMAD3MAD3 inhibitorMMAC1MMAC1 proteinMajor Histocompatibility Complex Enhancer-Binding Protein MAD3MethylationMissionModelingModificationMolecular Dynamics SimulationMolecular InteractionMutated in Multiple Advanced Cancers 1MutationNF-Kappa B Inhibitor AlphaNF-kappaB inhibitor alphaNFKBINFKBIANFKBIA geneNational Institutes of HealthNeural Stem CellNeuroglial NeoplasmNeuroglial TumorNuclearNuclear Factor Kappa-B InhibitorNuclear Factor of Kappa Light Chain Gene Enhancer in B Cells InhibitorNuclear Factor of Kappa Light Chain Gene Enhancer in B Cells Inhibitor, AlphaPHTS genePHTS proteinPRC1PRC1 ProteinPTENPTEN genePTEN proteinPTEN1Pediatric GliomaPediatric high-grade gliomaPhenotypePhosphatase and Tensin HomologPhosphatase and Tensin Homolog Deleted on Chromosome 10PhosphorylationPlayPolycombPolycomb Repressive Complex 1ProcessProgenitor CellsPrognosisProtein PhosphorylationProteinsPublic HealthRNA ExpressionRecurrenceRecurrentRegulationResearchResistanceRoleSUMOylationShapesSpecific qualifier valueSpecificitySpecifiedStem Cell likeSumoylation PathwayTherapeuticTranscriptionUnited States National Institutes of HealthVariantVariationcellular differentiationchromatin modifierdefined contributiondevelopmentaldrivingenzyme therapyepidermal growth factor receptor VIIIgenes structuregenome editinggenome mutationgenomic editingglial-derived tumorglioblastoma multiformeglioma cancer stem cellglioma cancer stem like cellglioma genesisglioma progenitorglioma stem cellsglioma stem like cellglobal gene expressionglobal transcription profileheterozygosityhiPSChistone methylationhuman iPShuman iPSChuman induced pluripotent cellhuman induced pluripotent stem cellshuman inducible pluripotent stem cellshuman inducible stem cellsinduced human pluripotent stem cellsinsightloss of functionmethylomemolecular dynamicsmutantmutated in multiple advanced cancers 1 proteinnerve stem cellneuralneural precursorneural precursor cellneural progenitorneural progenitor cellsneural stem and progenitor cellsneurogenic progenitorsneurogenic stem cellneuroglia neoplasmneuroglia tumorneuron progenitorsneuronal progenitorneuronal progenitor cellsneuronal stem cellsneuroprogenitornovelpediatricphosphatase and tensin homologue on chromosome tenposttranscriptionalprogenitor and neural stem cellsprogenitor capacityprogenitor cell likeprogenitor-likeprogramsrecruitresistantsmall moleculesocial rolespongioblastoma multiformestem cell characteristicsstem cellsstem-likestemnessthree dimensionaltranscriptional silencingtranscriptometumortumors in the brain
Get Agency plan to apply$29.99/mo · 7-day free trial · pipeline · alerts
or
— or —Get email alerts for similar roles
Description preview
Gliomas arise from neural progenitor cells (NPCs) or their descendants that derive transcriptional identity from
aberrant chromatin landscapes. Polycomb repressive complex 2 (PRC2) is a crucial chromatin modifier that
orchestrates gene silencing and organizes genome architecture during lineage specification and commitment by
depositing repressive…
🔒
Start 7-day free trial — $29.99/mo →Full details available on the Agency plan
Unlock the complete grant description, eligibility criteria, contract value, evaluation details and apply link — plus alerts, pipeline tracking, and CSV export.
Agency Plan
7-day free trialUnlock procurement & grants
Upgrade to access active tenders from World Bank, UNDP, ADB and more — with email alerts and pipeline tracking.
$29.99 / month
- 🔔Email alerts for new matching tenders
- 🗂️Track tenders in your pipeline
- 💰Filter by contract value
- 📥Export results to CSV
- 📌Save searches with one click