grant
Role of MUC1 in the host defense against urinary tract infection
Organization UNIVERSITY OF PITTSBURGH AT PITTSBURGHLocation PITTSBURGH, UNITED STATESPosted 10 Jun 2024Deadline 30 Apr 2029
NIHUS FederalResearch GrantFY20251-Phosphatidylinositol 3-KinaseAdhesionsAffectAlimentary CanalAnti-microbial Drug ResistanceAnti-microbial Drug ResistantAntibiotic ResistanceAntimicrobial Drug ResistanceAntimicrobial Drug ResistantApicalBacteriaBacterial InfectionsBasal Transcription FactorBasal transcription factor genesBindingBladderBladder Transitional Cell EpitheliumBladder Urinary SystemBladder UrotheliumBody TissuesCell BodyCell Communication and SignalingCell LineCell NucleusCell SignalingCell Surface GlycoproteinsCellLineCellsClinicalCultured CellsCulturing, in vitro Vertebrate, PrimaryCytoplasmic DomainCytoplasmic TailDark CellDataDigestive TractDrugsE coliE. coliElementsEpithelial CellsEpitheliumEscherichia coliExhibitsExperimental ModelsExternal DomainExtracellular DomainFemaleGI TractGastrointestinal TractGastrointestinal tract structureGene TranscriptionGeneral Transcription Factor GeneGeneral Transcription FactorsGenetic TranscriptionGoalsHost DefenseHost Defense MechanismHumanImmune responseImmunoglobulin Enhancer-Binding ProteinInfectionInfective cystitisInflammasomeInflammationInflammatoryInflammatory ResponseInjury to KidneyIntercalated CellInterventionIntracellular Communication and SignalingKO miceKidneyKidney Urinary SystemKinasesKnock-out MiceKnockout MiceLaboratoriesMUC-1MUC1MUC1 gene productMediatingMedicationMembrane GlycoproteinsMetabolic GlycosylationMiceMice MammalsMicrobeMicrobial Drug ResistanceModelingModern ManMolecular InteractionMuc1 MucinMucin 1Mucin 1 proteinMucinsMucosaMucosal TissueMucous MembraneMucus GlycoproteinMurineMusNF-kBNF-kappa BNF-kappaBNFKBNamesNuclear Factor kappa BNuclear Transcription Factor NF-kBNucleusNull MousePI-3 KinasePI3-KinasePI3CGPI3KGammaPI3kPIK3PIK3CGPIK3CG genePathogenesisPathway interactionsPatientsPatternPhagocytosisPharmaceutical PreparationsPhosphatidylinositol 3-KinasePhosphatidylinositol-3-OH KinasePhosphoinositide 3-HydroxykinasePhosphotransferase GenePhosphotransferasesPlayPrimary Cell CulturesProductionProteinsProximal Kidney TubulesPtdIns 3-KinasePublishingPulmonary Body SystemPulmonary Organ SystemPyelonephritisRNA ExpressionReactionReceptor ProteinRecoveryRecurrenceRecurrentResearchResistance to antibioticsResistant to antibioticsRespiratory SystemRespiratory TractsRespiratory tract structureRiskRoleSeveritiesSignal TransductionSignal Transduction SystemsSignalingSiteSourceStrains Cell LinesSurfaceSurface GlycoproteinsTHGPTHP geneTHP proteinTLR proteinTandem Repeat SequencesTandem RepeatsTherapeuticTissuesToll-Like Receptor Family GeneToll-like receptorsTransactivationTranscriptionTranscription Factor NF-kBTranscription Factor Proto-OncogeneTranscription factor genesTransphosphorylasesType I Phosphatidylinositol KinaseType III Phosphoinositide 3-KinaseUMODUMOD geneUPECUnited StatesUrinary tractUrinary tract infectionUrinary tract infectious diseaseUrineUropathogenic E coliUropathogenic E. coliUropathogenic Escherichia coliUrotheliumV-ATPaseV-type ATPaseWomanalimentary tractanti-microbialanti-microbial peptideantibiotic drug resistanceantibiotic resistantantimicrobialbacteria infectionbacteria pathogenbacterial adhesin receptorbacterial diseasebacterial pathogenbiological signal transductionbladder infectioncopingcostcultured cell linedigestive canaldrug/agentglycosylationhost responseimmune system responseimmunoresponseinsightischemia injuryischemic injurykappa B Enhancer Binding Proteinkidney infectionkidney injurymicrobialmicrobial drug resistantmouse modelmurine modelnamenamednamingnovelnuclear factor kappa betapathogenpathogenic bacteriapathwaypreservationpreventpreventingreceptorrenalrenal injuryrenal proximal tubuleresponsesocial rolestable cell linetraffickingtrans-activationtranscription factorurinaryurinary bladderurinary infectionuromodulinvacuolar ATPasevacuolar H+-ATPasevacuolar membrane H(+)-ATPase♀
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Project Summary (Abstract)
Urinary tract infections (UTI) are one of the most common bacterial infections and are caused predominantly by
uropathogenic Escherichia coli (UPEC). While broad-spectrum antimicrobials have been the drug of choice to
treat UTIs, the emergence of antimicrobial drug resistance and related recurrent UTI suggests that this…
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