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Role of mTORC1 signaling in type 1 diabetes
Organization UNIVERSITY OF MIAMI SCHOOL OF MEDICINELocation CORAL GABLES, UNITED STATESPosted 1 Apr 2022Deadline 31 Mar 2026 โ ๏ธ
NIHUS FederalResearch GrantFY20254E-BP1AddressAdoptive TransferAdult-Onset Diabetes MellitusAllogenicAntigensApoptosisApoptosis PathwayAutoimmuneAutoimmune DiseasesB Cell ProliferationB blood cellsB cellB cellsB-CellsB-LymphocytesB-cellBP2Beta CellBiological FunctionBiological ProcessBlast TransformationBlastogenesisBody TissuesBrittle Diabetes MellitusCD8 CellCD8 T cellsCD8 lymphocyteCD8+ T cellCD8+ T-LymphocyteCD8-Positive LymphocytesCD8-Positive T-LymphocytesCell Communication and SignalingCell DeathCell FunctionCell PhysiologyCell ProcessCell SignalingCell SizeCell SurvivalCell ViabilityCell divisionCellular FunctionCellular PhysiologyCellular ProcessComplementComplement ProteinsComplexD-GlucoseDataDermatoplastiesDermatoplastyDevelopmentDextroseDiabetes MellitusDiabetes preventionDiseaseDisorderEIF4EBP1EIF4EBP1 geneEnvironmentFK506 Binding Protein 12-Rapamycin Associated Protein 1FKBP12 Rapamycin Complex Associated Protein 1FRAP1FRAP1 geneFRAP2GenderGeneralized GrowthGlucoseGrowthGrowth AgentsGrowth FactorGrowth SubstancesIBP2IDDMIGF-BP53IGFBP2IGFBP2 geneIRS2IRS2 geneImmune TargetingImmune responseImmune systemImmunomodulationIn VitroIncidenceInfiltrationInflammatoryInjuryInsulin CellInsulin Receptor Substrate 2Insulin ResistanceInsulin Secreting CellInsulin-Dependent Diabetes MellitusInsulin-Like Growth Factor Binding Protein 2Intermediary MetabolismIntracellular Communication and SignalingJuvenile-Onset Diabetes MellitusKetosis-Prone Diabetes MellitusKetosis-Resistant Diabetes MellitusKnowledgeLipidsLymphatic cellLymphoblast TransformationLymphocyteLymphocyte ActivationLymphocyte StimulationLymphocyte TransformationLymphocyticLymphoidMaturity-Onset Diabetes MellitusMechanistic Target of RapamycinMediatingMessenger RNAMetabolic ProcessesMetabolismMiceMice MammalsModelingMolecularMolecular FingerprintingMolecular ProfilingMurineMusNIDDMNon-Insulin Dependent DiabetesNon-Insulin-Dependent Diabetes MellitusNoninsulin Dependent DiabetesNoninsulin Dependent Diabetes MellitusNutrientPathway interactionsPatientsPhenotypePhosphorylationPopulationPreventionProgrammed Cell DeathProliferatingProtein PhosphorylationProteinsProteins Growth FactorsPublishingRAFT1RegulationRegulatory T-LymphocyteRoleSCID MiceSelf ToleranceSevere Combined Immunodeficient MiceSignal TransductionSignal Transduction SystemsSignalingSkin TransplantationSlow-Onset Diabetes MellitusSplenocyteStable Diabetes MellitusSubcellular ProcessSudden-Onset Diabetes MellitusT cell responseT-CellsT-LymphocyteT1 DMT1 diabetesT1DT1DMT2 DMT2DT2DMT8 CellsT8 LymphocytesTeff cellTestingTherapeuticTissue GrowthTissuesTranslation InitiationTranslationsTregType 1 Diabetes MellitusType 1 diabetesType 2 Diabetes MellitusType 2 diabetesType I Diabetes MellitusType II Diabetes MellitusType II diabetesUpregulationadaptive immunityadult onset diabetesautoimmune conditionautoimmune disorderautoimmunity diseaseautoreactive T cellbiological signal transductioncell regenerationcellular regenerationcomplementationcytokinecytotoxicdesigndesigningdevelopmentaldiabetesdiabetes controldiabetes mellitus controldrug developmenteffector T cellhost responsehuman diseaseimmune modulationimmune regulationimmune system responseimmunogenimmunologic reactivity controlimmunomodulatoryimmunoregulationimmunoregulatoryimmunoresponseinflammatory environmentinflammatory milieuinjuriesinsightinsulin dependent diabetesinsulin dependent type 1insulin resistantinsulin secretioninsulin toleranceinsulitisisletjuvenile diabetesjuvenile diabetes mellitusketosis prone diabetesketosis resistant diabeteslymph celllymphocyte proliferationmRNAmTORmalemammalian target of rapamycinmaturity onset diabetesmolecular profilemolecular signaturemouse modelmurine modelnecrocytosisnew drug treatmentsnew drugsnew pharmacological therapeuticnew therapeutic approachnew therapeutic interventionnew therapeutic strategiesnew therapeuticsnew therapynew therapy approachesnew treatment approachnew treatment strategynext generation therapeuticsnovelnovel drug treatmentsnovel drugsnovel pharmaco-therapeuticnovel pharmacological therapeuticnovel therapeutic approachnovel therapeutic interventionnovel therapeutic strategiesnovel therapeuticsnovel therapynovel therapy approachontogenypathwaypharmacologicpreservationpreventpreventingregulatory T-cellsresponseself-reactive T cellsensorsex dimorphismsexual dimorphismsexually dimorphicsocial rolethymus derived lymphocytetranslationtype 2 DMtype I diabetestype II DMtype one diabetestype two diabetesฮฒ-cellฮฒ-cellsฮฒCellโ
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Project Summary/Abstract
Type 1 diabetes (T1D) is a devastating disease with increased incidence in the world. Proposed therapeutic
therapies for this disease have focused on preservation of beta cells and immunomodulation. The mTOR
complex 1 (mTORC1), a nutrient sensor, regulates beta cell mass and proliferation by acting on S6K and 4E-
BPs, twoโฆ
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