grant
Role of metabolic crosstalk in determining immunity during tumor progression
Organization BRIGHAM AND WOMEN'S HOSPITALLocation BOSTON, UNITED STATESPosted 14 Jul 2023Deadline 30 Jun 2028
NIHUS FederalResearch GrantFY2025AcetylationAcetyltransferaseAffectAlgorithmic AnalysesAlgorithmic AnalysisAnalyses of AlgorithmsAnalysis of AlgorithmsAutoimmune StatusAutoimmunityBiochemical PathwayBody TissuesCAGBCD8 CellCD8 T cellsCD8 lymphocyteCD8+ T cellCD8+ T-LymphocyteCD8-Positive LymphocytesCD8-Positive T-LymphocytesCGCBCancer TreatmentCancersCell BodyCell FunctionCell PhysiologyCell ProcessCellsCellular FunctionCellular Metabolic ProcessCellular PhysiologyCellular ProcessComputing MethodologiesDataData SetEcologic SystemsEcological SystemsEcosystemEnzyme GeneEnzymesEquilibriumGenesGoalsImmuneImmune TargetingImmune ToleranceImmune infiltratesImmune systemImmunesImmunityImmunologic ToleranceIn SituIndividualIntermediary MetabolismKnowledgeLIAGMAC387MRP14Malignant CellMalignant MelanomaMalignant Neoplasm TherapyMalignant Neoplasm TreatmentMalignant NeoplasmsMalignant TumorMapsMediatingMelanomaMelanoma CellMelanoma TumorMetabolicMetabolic NetworksMetabolic ProcessesMetabolismMethodsMiceMice MammalsModelingMorbidityMorbidity - disease rateMurineMusMutant Strains MiceMyelogenousMyeloidMyeloid CellsMyeloid-derived suppressor cellsNetwork-basedOutcomeOxidative PhosphorylationOxidative Phosphorylation PathwayPathway interactionsPhenotypePolyamine CompoundPolyaminesPopulationProductionProductivityProliferatingRecyclingRegulatory T-LymphocyteResolutionRoleS100A9S100A9 geneShapesSpermidineSpermineStem Cell likeSubcellular ProcessSymbiosisSystemT8 CellsT8 LymphocytesTeff cellTherapeutic InterventionTimeTissue HarvestingTissuesTregTumor CellTumor ImmunityTumor growth in melanomaanalyzing longitudinalanti-cancer therapyanti-tumor immunityantitumor immunitybalancebalance functioncancer cellcancer immunitycancer microenvironmentcancer progressioncancer therapycancer-directed therapycell metabolismcell typecellular metabaolismcommensalismcomputational methodologycomputational methodscomputer based methodcomputer methodscomputing methodconditional mutantconditional mutationdesigndesigningdisabledeffector T cellexhaustfightingimmune cell infiltrateimmune system toleranceimmune unresponsivenessimmunological paralysisimmunosuppressive myeloid cellsin silicoin vivointervention therapylongitudinal analysismalignancymelanoma cancer modelmelanoma modelmelanoma tumor modelmetabolic profilemetabolism measurementmetabolomicsmetabonomicsmortalitymouse modelmouse mutantmurine modelmyeloid suppressor cellsmyeloid-derived suppressive cellsneoplasm progressionneoplasm/cancerneoplastic cellneoplastic progressionnovelnutrient deprivationnutritional deprivationpathwaypre-clinicalpreclinicalprogenitor capacityprogenitor cell likeprogenitor-likeregulatory T-cellsresolutionsresponsescRNA sequencingscRNA-seqsingle cell RNA-seqsingle cell RNAseqsingle cell expression profilingsingle cell transcriptomic profilingsingle-cell RNA sequencingsocial rolespatial RNA sequencingspatial gene expression analysisspatial gene expression profilingspatial resolved transcriptome sequencingspatial transcriptome analysisspatial transcriptome profilingspatial transcriptome sequencingspatial transcriptomicsspatially resolved transcriptomicsspatio transcriptomicsstem cell characteristicsstem-likestemnesssuppressive myeloid cellstargeted drug therapytargeted drug treatmentstargeted therapeutictargeted therapeutic agentstargeted therapytargeted treatmenttooltumortumor microenvironmenttumor progressionwasting
Description preview
PROJECT SUMMARY
Tumor cells and infiltrating immune cells co-evolve during the course of tumor progression, with the immune
system progressively losing its efficacy as tumors advance. Immune cells are highly dependent on cellular
metabolism to manifest their effector functions, but in the tumor microenvironment (TME), ‘metabolic competition’
with…
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