grant
Role of isoLGs and neutrophils in psoriasis-induced renal dysfunction and hypertension
Organization VANDERBILT UNIVERSITY MEDICAL CENTERLocation NASHVILLE, UNITED STATESPosted 15 Aug 2025Deadline 31 Jul 2030
NIHUS FederalResearch GrantFY2025AddressAnimal ModelAnimal Models and Related StudiesArachidonic AcidsAreaAutoimmune DiseasesBlood NeutrophilBlood PlasmaBlood Polymorphonuclear NeutrophilBlood monocyteBone MarrowBone Marrow Reticuloendothelial SystemCardiovascular DiseasesCell BodyCellsChronic Kidney FailureChronic Renal DiseaseChronic Renal FailureColony Stimulating Factor 3CutaneousCutaneous DisorderDataDendritic CellsDermatosesDevelopmentENaCEpidemiologyExhibitsGranulocyte Colony-Stimulating FactorGranulopoiesisHumanHypertensionHypertensive NephropathyImmuneImmunesImmunityIncidenceInterleukinsInvestigatorsKidneyKidney DiseasesKidney Urinary SystemKnowledgeLinkMarrow NeutrophilMarrow monocyteMediatingMediatorMentorshipMiceMice MammalsModern ManMolecularMorbidityMorbidity - disease rateMurineMusNa elementNephropathyNeutrophil InfiltrationNeutrophil RecruitmentNeutrophilic GranulocyteNeutrophilic InfiltrateNeutrophilic LeukocyteOrganPathogenesisPathogenicityPlasmaPlasma SerumPlayPluripoietinPolymorphonuclear CellPolymorphonuclear LeukocytesPolymorphonuclear NeutrophilsProductionProteinsPsoriasisPsychosocial EffectReagentRenal DiseaseRenal HypertensionResearchResearch PersonnelResearchersReticuloendothelial System, Serum, PlasmaRiskRoleSeveritiesSkinSkin DiseasesSkin Diseases and ManifestationsSodiumT-CellsT-LymphocyteTestingTreatment/Psychosocial EffectsVascular Hypertensive DiseaseVascular Hypertensive DisorderVeiled CellsWorkadductautoimmune conditionautoimmune cutaneous diseaseautoimmune dermatologic diseaseautoimmune dermatologic disorderautoimmune dermatosesautoimmune disorderautoimmune skin conditionautoimmune skin diseaseautoimmune skin disorderautoimmunity diseasebenefit sharingblood pressure elevationcardiovascular disease riskcardiovascular disordercardiovascular disorder riskchronic kidney diseaseco-morbidco-morbiditycomorbiditycompare to controlcomparison controlcutaneous diseasecutaneous lesionscytokinedamage to kidneydermal diseasedermal disorderdermal lesiondevelopmentalelevated blood pressureepidemiologicepidemiologicalepithelial Na+ channelepithelial sodium channelexperienceextracellulargranulocyte colony stimulating factorhigh blood pressurehuman diseasehyperpiesiahyperpiesishypertensivehypertensive diseasehypertensive disorderhypertensive kidneyincrease in blood pressureincreased blood pressureinnovateinnovationinnovativeinterestkeratinocytekidney damagekidney disorderkidney dysfunctionmodel of animalmonocytemortalitymouse modelmurine modelneutrophilnew drug treatmentsnew drugsnew pharmacological therapeuticnew therapeuticsnew therapynext generation therapeuticsnovelnovel drug treatmentsnovel drugsnovel pharmaco-therapeuticnovel pharmacological therapeuticnovel therapeuticsnovel therapyoverexpressoverexpressionoxidationprogramspsoriasiformpsoriaticpsychosocialrenalrenal damagerenal disorderrenal dysfunctionskin disorderskin lesionsocial rolethymus derived lymphocyteward
Description preview
Project Summary
Psoriasis is a prevalent autoimmune disease involving formation of scaly and pruritic plaques on the skin.
Although these skin lesions cause significant negative physical and psychosocial effects, the major morbidity
and mortality from psoriasis occurs through markedly increased risk of kidney and cardiovascular disease such
as…
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