grant
Role of interstitial cells of Cajal in patterned colonic motor activity
Organization UNIVERSITY OF NEVADA RENOLocation RENO, UNITED STATESPosted 1 Mar 2019Deadline 29 Feb 2028
NIHUS FederalResearch GrantFY20253-D3-Dimensional3DAddressAgingAlimentary CanalAnatomic SitesAnatomic structuresAnatomyAnimal ModelAnimal Models and Related StudiesAnimalsAuerbach's PlexusBehaviorBody TissuesCell BodyCell Communication and SignalingCell ShapeCell SignalingCell membraneCell-Extracellular MatrixCellsCellular MatrixCharacteristicsColonCommunicating JunctionComparative StudyConsensusConstipationCytoplasmic MembraneCytoskeletal SystemCytoskeletonDataDefectDiabetes MellitusDigestive TractDisablingDistalECMElectrophysiologyElectrophysiology (science)EnteralEntericEventExtracellular MatrixFamilyFundingGI TractGap JunctionsGastrointestinal MotilityGastrointestinal TractGastrointestinal tract structureGiant CellsHumanImageIn SituInterstitial Cell of CajalIntracellular Communication and SignalingInvestigationInvoluntary MuscleKnowledgeLearningLeiomyocyteLocomotor ActivityLow-resistance JunctionMaintenanceMediatingMembraneMembrane PotentialsMiceMice MammalsMigrating Motor ComplexMigrating Myoelectric ComplexModelingModern ManMorphologyMotilityMotorMotor ActivityMotor CellMotor NeuronsMovementMultinucleated Giant CellsMurineMusMuscleMuscle TissueMyenteric PlexusNerveNerve CellsNerve Impulse TransmissionNerve TransmissionNerve Transmitter SubstancesNerve UnitNeural CellNeurocyteNeuronal TransmissionNeuronsNeurophysiology / ElectrophysiologyNeurotransmittersNexus JunctionNormal CellObstructionOperative ProceduresOperative Surgical ProceduresOrganOutcomeOutputPace StimulatorsPacemakersPathologyPatientsPatternPeristalsisPhasePhysiologyPlasma MembranePolykaryocytesPopulationPublishingReceptor ProteinRegulationResting PotentialsRoleSignal TransductionSignal Transduction SystemsSignalingSmall IntestinesSmooth MuscleSmooth Muscle CellsSmooth Muscle MyocytesSmooth Muscle Tissue CellStomachStretchingSurgicalSurgical InterventionsSurgical ProcedureSymptomsSyncytiumTechniquesTestingTimeTissuesTransgenic OrganismsTransmembrane PotentialsTzanck CellWorkalimentary tractaxon signalingaxon-glial signalingaxonal signalingbiological signal transductionbody movementconfocal imagingdiabetesdigestive canaldysmotilitydysmotility syndromeelectrophysiologicalexperimentexperimental researchexperimental studyexperimentsgastricgastrointestinalglia signalingglial signalinghigh resolution imagingimagingimprovedinnervationinsightintracellular skeletonloss of functionmembrane structuremodel of animalmotility disordermotoneuronmouse modelmurine modelmuscularmutantnerve signalingnerve supplyneuralneural controlneural mechanismneural regulationneural signalingneuromechanismneuromodulationneuromodulatoryneuronalneuronal signalingneuroregulationneurotransmissionnoveloptogeneticsplasmalemmapre-clinical studypreclinical studyreceptorresponsesensorsmall bowelsocial rolesurgerytherapeutic evaluationtherapeutic testingthree dimensionaltooltransgenic
Description preview
Summary
Colonic motility is the product of myogenic and neurogenic factors that regulate the excitability of smooth muscle
cells (SMCs). Part of the myogenic component of regulation is due to interstitial cells of Cajal (ICC) that have
critical functions in gastrointestinal (GI) motility. ICC form gap junctions with SMCs and convey regulatory…
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