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Role of IGFBP3 in Neonatal Heart Regeneration
Organization COLUMBIA UNIVERSITY HEALTH SCIENCESLocation NEW YORK, UNITED STATESPosted 1 Apr 2022Deadline 31 Mar 2026 β οΈ
NIHUS FederalResearch GrantFY202521+ years oldAbscissionAddressAdultAdult HumanAdvisory CommitteesAgeApicalAwardBeta CellBindingBiologyBlood SerumBlood VesselsBody TissuesCaliforniaCandidate Disease GeneCandidate GeneCardiacCardiac DiseasesCardiac DisordersCardiac Muscle CellsCardiac MyocytesCardiac TransplantationCardiac infarctionCardiocyteCardiologyCardiovascularCardiovascular Body SystemCardiovascular DiseasesCardiovascular Organ SystemCardiovascular systemCareer CounselingCareer GuidanceCause of DeathCell BodyCell Communication and SignalingCell CountCell Cycle ArrestCell DeathCell LineageCell NumberCell SignalingCell TransplantationCell divisionCell secretionCellsCellular SecretionCessation of lifeCicatrixDataDeathDeteriorationDevelopmentDevelopmental BiologyDrugsEndothelial CellsEndotheliumExcisionExhibitsExtirpationFailureFellowshipFibroblastsGenetic ModelsHealth Care SystemsHeartHeart DiseasesHeart GraftingHeart Muscle CellsHeart TransplantationHeart VascularHeart failureHeart myocyteHumanIGF-Binding Protein 3IGF-Binding ProteinsIGF2IGF2 geneIGFBPIGFBP-3ImpairmentInjuryInsulin CellInsulin ReceptorInsulin Receptor Protein-Tyrosine KinaseInsulin Secreting CellInsulin-Dependent Tyrosine Protein KinaseInsulin-Like Growth Factor Binding Protein 3Insulin-Like Growth-Factor-Binding ProteinsInternal MedicineIntracellular Communication and SignalingInvestigatorsIschemic HeartIschemic Heart DiseaseIschemic myocardiumKO miceKnock-out MiceKnockout MiceKnowledgeLaboratoriesLaboratory StudyLifeM PhaseMapsMechanicsMediatingMedicationMentorsMiceMice MammalsMicro Array DataMitogensMitosisMitosis StageMitoticModern ManMolecularMolecular InteractionMurineMusMuscle CellsMyocardial InfarctMyocardial InfarctionMyocardial IschemiaMyocytesNatural regenerationNeonatalNull MouseOccupational GuidanceOperative ProceduresOperative Surgical ProceduresOrganOutputPatientsPharmaceutical PreparationsPhysiciansProliferatingProtein FamilyProtein SecretionProteinsRecombinant Insulin-Like Growth FactorRecombinantsRegenerationRemovalResearchResearch PersonnelResearchersResidenciesRh IGFRh Insulin Like Growth FactorRoleSan FranciscoScarsScientistSerumSignal InductionSignal PathwaySignal TransductionSignal Transduction SystemsSignalingSomatomedin-Binding ProteinsSourceSurgicalSurgical InterventionsSurgical ProcedureSurgical RemovalTask ForcesTexasTissuesTrainingTranslatingUniversitiesVentricularVocational CounselingVocational GuidanceWritingadulthoodadvisory teamaged miceaged mouseagesbiological signal transductioncardiac failurecardiac functioncardiac graftcardiac infarctcardiac ischemiacardiac regenerationcardiomyocytecardiovascular disordercareer counselorcareer developmentcell typecellular transplantcirculatory systemconditional knock-outconditional knockoutcoronary attackcoronary infarctcoronary infarctioncoronary ischemiadefined contributiondevelopmentaldrug/agentelderly miceexecutive coachingexperienceexperimentexperimental researchexperimental studyexperimentsfunction of the hearthealth care burdenheart attackheart disorderheart functionheart infarctheart infarctionheart ischemiaheart regenerationheart transplantimprovedinjuriesinjury responseinsightinstructorinsulinlike growth factor binding proteinischemic cardiomyopathymechanicmechanicalmouse modelmurine modelmutantmyocardial ischemia/hypoxiamyocardium ischemianecrocytosisneonatal injuryneonatal miceneonatenew drug treatmentsnew drugsnew pharmacological therapeuticnew therapeuticsnew therapynext generation therapeuticsnovelnovel drug treatmentsnovel drugsnovel pharmaco-therapeuticnovel pharmacological therapeuticnovel therapeuticsnovel therapyold miceoverexpressoverexpressionparacrineregenerateregeneration based therapyregeneration therapyregenerativeregenerative therapeuticsregenerative therapyresectionresponse to injurysocial rolespatial and temporalspatial temporalspatiotemporalsurgerytherapeutic candidatevascularΞ²-cellΞ²-cellsΞ²Cell
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Description preview
Project Summary/Abstract
This is an application for a K08 award for Dr. Shah Ali, MD, an Instructor in Cardiology at the University
of Texas Southwestern (UTSW), for his transition from Instructor to independent investigator in basic
cardiovascular biology with a focus on cardiac regeneration. He has completed residency training in Internalβ¦
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