grant
Role of hexokinase 3 in macrophage polarization and cardiac remodeling after myocardial infraction.
Organization UNIVERSITY OF ARIZONALocation TUCSON, UNITED STATESPosted 1 Sept 2025Deadline 30 Jun 2029
NIHUS FederalResearch GrantFY2025Active OxygenAcuteAntibodiesAntioxidantsBlood NeutrophilBlood Polymorphonuclear NeutrophilBlood monocyteBody TissuesBone MarrowBone Marrow Reticuloendothelial SystemButhionine SulfoximineCRISPR approachCRISPR based approachCRISPR methodCRISPR methodologyCRISPR techniqueCRISPR technologyCRISPR toolsCRISPR-CAS-9CRISPR-based methodCRISPR-based techniqueCRISPR-based technologyCRISPR-based toolCRISPR/CAS approachCRISPR/Cas methodCRISPR/Cas technologyCRISPR/Cas9CRISPR/Cas9 technologyCarbonCardiacCardiac infarctionCas nuclease technologyCause of DeathCell BodyCellsChIP SequencingChIP-seqChIPseqClustered Regularly Interspaced Short Palindromic Repeats approachClustered Regularly Interspaced Short Palindromic Repeats methodClustered Regularly Interspaced Short Palindromic Repeats methodologyClustered Regularly Interspaced Short Palindromic Repeats techniqueClustered Regularly Interspaced Short Palindromic Repeats technologyCoenzyme IID-GlucoseDataDextroseDiseaseDisorderDrug Metabolic DetoxicationDrug Metabolic DetoxificationExonsGCS InhibitorsGamma-Glutamylcysteine Synthetase InhibitorGene TranscriptionGenesGenetic TranscriptionGlucoseGlutathioneGlutathione Synthesis InhibitorsHealthHeartHexokinase DHexose Monophosphate ShuntIntermediary MetabolismIschemiaIschemic HeartIschemic Heart DiseaseIschemic myocardiumIsoformsKnowledgeMacrophageMarrow NeutrophilMarrow monocyteMeasurementMeasuresMediatingMetabolicMetabolic Drug DetoxicationsMetabolic ProcessesMetabolismMetabolism of Toxic AgentsMiceMice MammalsMolecularMurineMusMyeloid CellsMyocardialMyocardial InfarctMyocardial InfarctionMyocardial IschemiaMφNAD phosphateNAD(H) phosphateNADH phosphateNADPNADPHNeutrophilic GranulocyteNeutrophilic LeukocyteNicotinamide-Adenine Dinucleotide PhosphateOxidation-ReductionOxidative StressOxygen RadicalsPathway interactionsPentose Phosphate PathwayPentose Phosphate ShuntPentose ShuntPentosephosphate PathwayPentosephosphate ShuntPhenotypePhosphatesPhosphorylationPlayPolymorphonuclear CellPolymorphonuclear LeukocytesPolymorphonuclear NeutrophilsPopulationPro-OxidantsProcessProductionProtein IsoformsProtein PhosphorylationProteomicsRNA ExpressionRNA SeqRNA sequencingRNAseqReactive Oxygen SpeciesRedoxRegulationReperfusion TherapyRoleSupplementationTamoxifenTestingTissuesTranscriptionTranscription ActivationTranscriptional ActivationTriphosphopyridine Nucleotidecardiac damagecardiac functioncardiac infarctcardiac ischemiachromatin immunoprecipitation coupled with sequencingchromatin immunoprecipitation followed by sequencingchromatin immunoprecipitation with sequencingchromatin immunoprecipitation-seqchromatin immunoprecipitation-sequencingclinical relevanceclinically relevantcoronary attackcoronary infarctcoronary infarctioncoronary ischemiadetoxificationfunction of the heartgamma-L-Glu-L-Cys-Glygamma-L-Glutamyl-L-Cysteinylglycineglucose metabolismheart attackheart damageheart functionheart infarctheart infarctionheart ischemiahexokinasehexokinase IVimprovedinhibitorinorganic phosphateischemia injuryischemic injurymonocytemyocardial ischemia/hypoxiamyocardium ischemianeutrophilnew drug treatmentsnew drugsnew pharmacological therapeuticnew therapeuticsnew therapynext generation therapeuticsnovelnovel drug treatmentsnovel drugsnovel pharmaco-therapeuticnovel pharmacological therapeuticnovel therapeuticsnovel therapyoxidation reduction reactionpathwayprotective effectrepairrepairedreperfusionrestraintsocial roletherapeutic targettissue repairtranscriptome sequencingtranscriptomic sequencing
Description preview
Project Summary
Myocardial infarction (MI) is a leading cause of death, and macrophages play a critical role in the remodeling of
the heart after MI. Hexokinases (HKs) catalyze glucose phosphorylation, and one HK isoform (HK3) is mostly
expressed in myeloid cells. We have generated global and macrophage-specific (MS)-Hk3-/- mice and have
shown…
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