grant
Role of Gasdermin-D in neonatal hyperoxia-induced systemic vascular remodeling and cardiac dysfunction
Organization UNIVERSITY OF MIAMI SCHOOL OF MEDICINELocation CORAL GABLES, UNITED STATESPosted 1 Apr 2026Deadline 28 Feb 2028
NIHUS FederalResearch GrantFY202621+ years oldAdultAdult HumanAirAntioxidantsBeta Proprotein Interleukin 1Blood PressureBlood VesselsCardiac DiseasesCardiac DisordersCardiovascularCardiovascular Body SystemCardiovascular DiseasesCardiovascular Organ SystemCardiovascular systemCell DeathCell membraneCell-Extracellular MatrixCytoplasmic MembraneDataDiseaseDisorderDown-RegulationDysfunctionECMEndothelial CellsEndotheliumEnsureExposure toExtracellular MatrixFibrosisFibrosis in the heartFibrosis in the myocardiumFibrosis within the heartFibrosis within the myocardiumFibrotic myocardiumFunctional disorderGeneticGoalsHeart DiseasesHeart VascularHeart failureHyperoxiaHypertensionIFN-Gamma-Inducing Factor GeneIFN-gamma-Inducing FactorIGIFIGIF GeneIL-1 GammaIL-1 Gamma GeneIL-1 betaIL-1 βIL-1-bIL-18IL-18 GeneIL-1gIL-1g GeneIL-1βIL1-BetaIL1-βIL18IL18 ProteinIL18 geneIL1B ProteinIL1F2IL1F4IL1F4 GeneIL1βImpairmentIndividualInflammasomeInflammationInflammatoryInflammatory ResponseInjuryInterferon-Gamma-Inducing Factor GeneInterferon-gamma-Inducing FactorInterleukin 18 (Interferon-Gamma-Inducing Factor)Interleukin 18 (Interferon-Gamma-Inducing Factor) GeneInterleukin 18 ProproteinInterleukin 18 Proprotein GeneInterleukin 1betaInterleukin-1 GammaInterleukin-1 Gamma GeneInterleukin-1 betaInterleukin-18Interleukin-18 PrecursorInterleukin-18 Precursor GeneInterleukin-1βIschemic HeartIschemic Heart DiseaseIschemic myocardiumKnowledgeLeft Ventricular FunctionLeiomyocyteLinkMGC12320MGC12320 GeneMediatingMiceMice MammalsMolecularMorbidityMurineMusMyocardial IschemiaMyocardial depressionMyocardial dysfunctionNeonatalNeonatal Hyperoxic InjuryO elementO2 elementOutcomeOxygenPathologicPhenotypePhysiopathologyPlasma MembranePlayPopulationPreinterleukin 1 BetaPremature BirthPremature InfantPrematurely deliveringPreterm BirthPreventative strategyPrevention strategyPreventive strategyProteinsPublic HealthResearchRiskRodent ModelRoleSmooth Muscle CellsSmooth Muscle MyocytesSmooth Muscle Tissue CellSurvivorsSystemic diseaseTestingTherapeuticTranslatingVascular DiseasesVascular DisorderVascular Endothelial CellVascular Hypertensive DiseaseVascular Hypertensive DisorderVascular SystemVascular remodelingWorkadulthoodangiogenesisblood pressure elevationblood vessel disordercardiac dysfunctioncardiac failurecardiac fibrosiscardiac functioncardiac ischemiacardiovascular disordercardiovascular riskcardiovascular risk factorcirculatory systemcoronary fibrosiscoronary ischemiacytokineeffective therapyeffective treatmentelevated blood pressureendothelial dysfunctionfibrotic heartfunction of the heartheart disorderheart dysfunctionheart fibrosisheart functionheart ischemiahigh blood pressurehyperoxygenationhyperpiesiahyperpiesishypertensive diseasehypertensive disorderimprovedin vivoincrease in blood pressureincreased blood pressureinfants born prematureinfants born prematurelyinflammation markerinflammatory markerinjuriesinjury to the vasculatureinsightlater in lifelater lifelife spanlifespanmouse modelmurine modelmyocardial fibrosismyocardial ischemia/hypoxiamyocardium ischemianecrocytosisneonatal careneonatal exposureneonatal hyperoxianeonatal miceneonatal morbiditynew therapeutic approachnew therapeutic interventionnew therapeutic strategiesnew therapy approachesnew treatment approachnew treatment strategynewborn morbiditynovelnovel therapeutic approachnovel therapeutic interventionnovel therapeutic strategiesnovel therapy approachpathophysiologypharmacologicplasmalemmapre-clinicalpreclinicalpremature babypremature childbirthpremature deliverypremature infant humanpreterm babypreterm deliverypreterm infantpreterm infant humanpreventpreventingpupsocial rolesupplemental oxygentranscriptomicstranslational opportunitiestranslational potentialtranslational therapeuticstranslational therapyvascularvascular dysfunctionvascular inflammationvascular injuryvasculopathy
Description preview
PROJECT SUMMARY
The population of preterm survivors has significantly increased due to advancements in neonatal care. However,
these individuals are later at risk for cardiovascular morbidities such as hypertension, ischemic heart disease,
and heart failure, which poses a global public health concern. Preterm infants often receive…
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