grant
Role of Etv4 and Etv5 in the self-renewal and differentiation of nephron progenitors
Organization CINCINNATI CHILDRENS HOSP MED CTRLocation CINCINNATI, UNITED STATESPosted 9 May 2023Deadline 30 Apr 2028
NIHUS FederalResearch GrantFY2026AddressAffectAutomobile DrivingBasal Transcription FactorBasal transcription factor genesBeta Cadherin-Associated ProteinBeta-1 CateninBirthBody TissuesCUL-2CUT&RUNCancersCell BodyCell Communication and SignalingCell LocomotionCell MigrationCell MovementCell SignalingCellsCellular MigrationCellular MotilityCleavage Targets and Release Using NucleaseCleavage Under Targets and Release Using NucleaseCystic kidneyDNA Synthesis FactorDataDefectDevelopmentDevelopmental BiologyDistalDoseDown-RegulationE1A Enhancer-Binding Protein E1AFE1A enhancer binding proteinE1A enhancer-binding protein FE1A-FE1AFETV4ETV4 geneEmbryoEmbryo DevelopmentEmbryogenesisEmbryonicEmbryonic DevelopmentEndothelial Cell Growth FactorEpitheliumEquilibriumEts Variant Protein 4ExtremitiesFGFFibroblast Growth FactorFibroblast Growth Factor Gene FamilyFibroblast Growth Regulatory FactorGDNFGDNF geneGene TranscriptionGeneral Transcription Factor GeneGeneral Transcription FactorsGenetic TranscriptionGestationHistologyHumanImmunofluorescenceImmunofluorescence ImmunologicIn VitroIndividualIntracellular Communication and SignalingInvadedKidneyKidney CystKidney Urinary SystemKnowledgeLeannessLimb structureLimbsLinkLoxP-flanked alleleLungLung Respiratory SystemMalignant NeoplasmsMalignant TumorMediatingMesenchymasMesenchymeMetanephric DiverticulumMetastasisMetastasizeMetastatic LesionMetastatic MassMetastatic NeoplasmMetastatic TumorMiceMice MammalsModelingModern ManMurineMusNeoplasm MetastasisNephronsNon-TrunkObesityOrganogenesisPEAS3PRO2286ParturitionPathway interactionsPregnancyProgenitor CellsRNA ExpressionRNA SeqRNA sequencingRNAseqRegulationRenal CystRoleSecondary NeoplasmSecondary TumorShapesSignal PathwaySignal TransductionSignal Transduction SystemsSignalingStem Cell likeTamoxifenTesticlesTestingTestisTherapeutic InterventionThinnessTissuesTranscriptionTranscription Factor Proto-OncogeneTranscription RepressorTranscription factor genesTranscriptional RepressorTubularTubular formationUndifferentiatedUpregulationUreteric BudUriniferous TubeVesicleWNT Signaling PathwayWNT signalingWNT4WNT4 geneWingless-Type MMTV Integration Site Family, Member 4adipositybalancebalance functionbeta catbeta cateninbiological signal transductioncancer metastasiscancer progressioncell motilityconfocal imagingcorpulencedevelopmentaldrivingets variant 4exhaustexhaustionfloxedfloxed allelegenetic repressorglial cell-line derived neurotrophic factorinsightintervention therapykidney developmentmalignancymigrationmotor neuron developmentmouse modelmurine modelmutantneoplasm progressionneoplasm/cancerneoplastic progressionnephrogenesisnephron progenitornovelpathwaypostnatalprematureprematuritypreventpreventingprogenitor capacityprogenitor cell differentiationprogenitor cell likeprogenitor cell maintenanceprogenitor cell poolprogenitor cell populationprogenitor cell regenerationprogenitor cell self renewalprogenitor differentiationprogenitor maintenanceprogenitor poolprogenitor populationprogenitor regenerationprogenitor self renewalprogenitor-likerenalscRNA sequencingscRNA-seqself-renewself-renewalsingle cell RNA-seqsingle cell RNAseqsingle cell expression profilingsingle cell transcriptomic profilingsingle-cell RNA sequencingsocial rolestem and progenitor cell populationstem and progenitor cell regenerationstem and progenitor cell self renewalstem and progenitor differentiationstem cell characteristicsstem cell differentiationstem cell maintenancestem cell poolstem cell populationstem cell regenerationstem cell self renewalstem cellsstem-likestemnesstranscription factortranscriptome sequencingtranscriptomic sequencingtumor cell metastasistumor progressionβ-catenin
Description preview
Abstract:
Etv4 and Etv5 (Etv4/5) are two transcription factors expressed in the developing mouse kidney, specifically in
the ureteric bud tips, the metanephric mesenchyme and the renal vesicle.
Our preliminary data using a mouse model of Etv4/5 deletion in the nephron progenitor cells (NPCs) and their
progeny demonstrate a critical role for these…
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