grant
Role of ERK1/2 signaling in SARS-CoV-2 -induced dysregulated immunity and lung pathology.
Organization OKLAHOMA STATE UNIVERSITY STILLWATERLocation STILLWATER, UNITED STATESPosted 6 Sept 2024Deadline 30 Jun 2029
NIHUS FederalResearch GrantFY20252019 novel corona virus2019 novel coronavirus2019-nCoVARDSAcute Lung InjuryAcute Pulmonary InjuryAcute Respiratory DistressAcute Respiratory Distress SyndromeAdrenal Cortex HormonesAdult ARDSAdult RDSAdult Respiratory Distress SyndromeAnti-viral AgentsAnti-viral ResponseAnti-viral TherapyAvian Influenza A VirusAvian Influenza VirusAvian Orthomyxovirus Type ABlood NeutrophilBlood Polymorphonuclear NeutrophilBlood monocyteCD8 CellCD8 T cellsCD8 lymphocyteCD8+ T cellCD8+ T-LymphocyteCD8-Positive LymphocytesCD8-Positive T-LymphocytesCOVID-19COVID-19 infectionCOVID-19 virusCOVID-19 virus infectionCOVID19 infectionCOVID19 virusCV-19Cell BodyCell Communication and SignalingCell LineCell SignalingCellLineCellsClinicalCoV-2CoV2CoronaviridaeCoronaviridae InfectionsCoronavirusCoronavirus InfectionsCoronavirus Infectious Disease 2019CorticoidsCorticosteroidsDa Nang LungDataDefective HybridsDefective Interfering ParticlesDefective Interfering VirusesDefective VirusesDoseERK 1ERK1ERK1 KinaseExtracellular Signal-Regulated Kinase 1FDA approvedFoundationsFowl Plague VirusHCoVHost FactorHost Factor ProteinHumanIFNImmune responseImmunityImpairmentIncomplete VirusesInflammationInflammation MediatorsInflammatoryInnate ImmunityIntegration Host FactorsInterferonsIntracellular Communication and SignalingKinasesLungLung InflammationLung Respiratory SystemLung damageLymphocytopeniaLymphopeniaMAP Kinase 3MAPK3MAPK3 Mitogen-Activated Protein KinaseMAPK3 geneMERS corona virusMERS coronavirusMERS virusMERS-CoVMacrophageMarrow NeutrophilMarrow monocyteMeasuresMediatingMediatorMiceMice MammalsMiddle East Respiratory Syndrome Corona VirusMiddle East Respiratory Syndrome CoronavirusMiddle East Respiratory Syndrome VirusMiddle East Respiratory Syndrome-CoVMiddle East Respiratory VirusMiddle East Respiratory coronavirusMiddle Eastern Respiratory Syndrome Corona virusMiddle Eastern Respiratory Syndrome CoronavirusMiddle Eastern Respiratory Syndrome VirusMiddle Eastern Respiratory Syndrome-CoVMitogen-Activated Protein Kinase 3Mitogen-Activated Protein Kinase 3 GeneModern ManMorbidityMorbidity - disease rateMurineMusMyelogenousMyeloidMyeloid CellsMyxovirus influenzae-A suisMyxovirus pestis galliMφNative ImmunityNatural ImmunityNeutrophilic GranulocyteNeutrophilic LeukocyteNon-Specific ImmunityNonspecific ImmunityOrthocoronavirinaeOutcomeP44ERK1PSTkinase p44mpkPathogenicityPhosphotransferase GenePhosphotransferasesPneumoniaPneumonitisPolymorphonuclear CellPolymorphonuclear LeukocytesPolymorphonuclear NeutrophilsPorcine Influenza A VirusPorcine Influenza VirusPorcine Influenza Virus Type APorcine Orthomyxovirus Type AProductionPublic HealthPublishingPulmonary InflammationPulmonary PathologyRoleSARS VirusSARS corona virusSARS corona virus 2SARS coronavirusSARS-Associated CoronavirusSARS-CO-V2SARS-COVID-2SARS-CoVSARS-CoV-1SARS-CoV-2SARS-CoV-2 infectionSARS-CoV2SARS-CoV2 infectionSARS-Related CoronavirusSARS-associated corona virus 2SARS-associated coronavirus 2SARS-coronavirus-2SARS-related corona virus 2SARS-related coronavirus 2SARSCoV2Severe Acute Respiratory CoronavirusSevere Acute Respiratory Coronavirus 2Severe Acute Respiratory Distress Syndrome CoV 2Severe Acute Respiratory Distress Syndrome Corona Virus 2Severe Acute Respiratory Distress Syndrome Coronavirus 2Severe Acute Respiratory Syndrome CoV 2Severe Acute Respiratory Syndrome VirusSevere Acute Respiratory Syndrome corona virusSevere Acute Respiratory Syndrome coronavirusSevere Acute Respiratory Syndrome-associated coronavirus 2Severe Acute Respiratory Syndrome-related coronavirus 2Severe acute respiratory syndrome associated corona virus 2Severe acute respiratory syndrome coronavirus 2Severe acute respiratory syndrome coronavirus 2 infectionSevere acute respiratory syndrome related corona virus 2Severity of illnessShock LungSignal TransductionSignal Transduction SystemsSignalingStiff lungStrains Cell LinesStructural ProteinSwine Influenza VirusT cell responseT-CellsT-LymphocyteT8 CellsT8 LymphocytesTIL4TLR proteinTLR2TLR2 geneTLR2 receptorTestingTherapeuticToll-Like Receptor 2Toll-Like Receptor Family GeneToll-like receptorsToll/Interleukin 1 Receptor-Like 4Toll/Interleukin 1 Receptor-Like 4 GeneToll/Interleukin 1 Receptor-Like Protein 4TransphosphorylasesTreatment EfficacyViralViral Gene ProductsViral Gene ProteinsViral ProteinsViral load measurementVirusWorkWuhan coronavirusadaptive immunityaged miceaged mouseantagonismantagonistanti-viral compoundanti-viral drugsanti-viral immunityanti-viral medicationanti-viral therapeuticanti-viralsantiviral immunityavian flu virusbiological signal transductionbird flu viruscorona viruscoronavirus disease 2019coronavirus disease 2019 infectioncoronavirus disease 2019 viruscoronavirus disease-19coronavirus disease-19 viruscoronavirus infectious disease-19cultured cell linecytokinedisease severityelderly miceextracellularhCoV19host responsehuman CoVhuman corona virushuman coronavirushuman modelimmune system responseimmunoresponseimprovedinfected with COVID-19infected with COVID19infected with SARS-CoV-2infected with SARS-CoV2infected with coronavirus disease 2019infected with severe acute respiratory syndrome coronavirus 2inflammatory mediatorinhibitorintervention efficacylung injurylung pathologymodel of humanmonocytemortalitymouse modelmurine modelnCoV2neutrophilnew drug treatmentsnew drugsnew pharmacological therapeuticnew therapeuticsnew therapynext generation therapeuticsnovelnovel drug treatmentsnovel drugsnovel pharmaco-therapeuticnovel pharmacological therapeuticnovel therapeuticsnovel therapyold micep44 MAPKpathogenic viruspulmonary damagepulmonary injurypulmonary tissue damagepulmonary tissue injuryrespiratory virusresponsescRNA sequencingscRNA-seqsevere acute respiratory syndrome-CoVsingle cell RNA-seqsingle cell RNAseqsingle cell expression profilingsingle cell transcriptomic profilingsingle-cell RNA sequencingsocial rolesuccesstherapeutic efficacytherapeutic evaluationtherapeutic testingtherapy efficacythymus derived lymphocyteviral RNAviral infectious disease treatmentviral pathogenvirus RNAvirus loadvirus pathogenvirus proteinwet lung
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Project Summary (Abstract):
Emerging and re-emerging respiratory viruses such as SARS-CoV, MERS-CoV, SARS-CoV-2, and
avian and swine influenza viruses continue to pose a significant challenge to public health. These highly
pathogenic viruses successfully evade host immunity and replicate to high titers, causing excessive
inflammation, acute lung…
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