grant
Role of epigenetic changes in intracellular survival and replication of Legionell pneumophila
Organization WESTERN KENTUCKY UNIVERSITYLocation BOWLING GREEN, UNITED STATESPosted 1 Sept 2024Deadline 31 Aug 2028
NIHUS FederalResearch GrantFY2025AlveolarAlveolar MacrophagesAntibodiesAssayBacteriaBindingBioassayBiochemical PathwayBiological AssayBiomedical ResearchBody TissuesCell BodyCell Communication and SignalingCell FunctionCell NucleusCell PhysiologyCell ProcessCell SignalingCellsCellular FunctionCellular PhysiologyCellular ProcessCellular biologyCenters for Disease ControlCenters for Disease Control and PreventionCenters for Disease Control and Prevention (U.S.)ChIP SequencingChIP-seqChIPseqChromatinCo-ImmunoprecipitationsCytoplasmDNADNA MethylationDNA Molecular BiologyDNA analysisDataData AnalysesData AnalysisDeoxyribonucleic AcidDifferential Gene ExpressionDisease OutbreaksDysfunctionEducationEducational aspectsEngineeringEnvironmentEpigeneticEpigenetic ChangeEpigenetic MechanismEpigenetic ProcessEukaryotic CellEuropeanEventExclusionExpression SignatureFunctional disorderGene Action RegulationGene ExpressionGene Expression AlterationGene Expression ProfileGene Expression RegulationGene RegulationGene Regulation ProcessGene TranscriptionGeneralized GrowthGenesGenetic TranscriptionGrowthHistonesHost Defense MechanismImmuneImmune EvasionImmune PrecipitationImmune responseImmunesImmunoprecipitationInfectionInflammatoryIntracellular Communication and SignalingKentuckyL pneumophilaL. pneumophilaLegionellaLegionella pneumoniaLegionella pneumophilaLegionella pneumophila InfectionsLegionnaires' DiseaseLegionnaires' pneumoniaLungLung ParenchymaLung Respiratory SystemLung TissueMacrophageMammalian CellMediatingMedicineMetabolic NetworksMethodsMethylationMiceMice MammalsMicrobiologyModificationMolecular BiologyMolecular InteractionMurineMusMφNGS MethodNGS systemNational Academy of SciencesNon-Polyadenylated RNANormal CellNotificationNuclear ExtractNuclear ProteinsNucleusOrganOutbreaksPathogenesisPathway interactionsPhysiopathologyPneumoniaPopulationPreventative measurePreventive measureProcessProteinsPublic HealthPulmonary MacrophagesRNARNA ExpressionRNA Gene ProductsRNA SeqRNA Sequence AnalysesRNA Sequence AnalysisRNA analysisRNA sequencingRNAseqResearchRibonucleic AcidRoleSignal TransductionSignal Transduction SystemsSignalingSortingStructure of parenchyma of lungSubcellular ProcessSystemT4SSTestingTissue GrowthTissue-Specific Differential Gene ExpressionTissue-Specific Gene ExpressionTissuesTranscriptionType IV Secretion SystemType IV Secretion System PathwayUnited StatesUnited States Centers for Disease ControlUnited States Centers for Disease Control and PreventionUnited States National Academy of SciencesUniversitiesUpregulationWorkanalyze DNAbacteria pathogenbacterial pathogenbiological signal transductionbisulfitecell biologychromatin immunoprecipitation coupled with sequencingchromatin immunoprecipitation followed by sequencingchromatin immunoprecipitation with sequencingchromatin immunoprecipitation-seqchromatin immunoprecipitation-sequencingdata interpretationdesigndesigningdifferential expressiondifferentially expressedemerging pathogenepigeneticallyexperienceexperimentexperimental researchexperimental studyexperimentsgene expression patterngene expression signatureglobal gene expressionglobal transcription profilehistone modificationhost responsehydrogen sulfitehydrosulfiteimmune evasiveimmune system responseimmunoresponsemethylation patternmutantnew pathogennew therapeutic approachnew therapeutic interventionnew therapeutic strategiesnew therapy approachesnew treatment approachnew treatment strategynext gen sequencingnext generation sequencingnextgen sequencingnon-histone proteinnonhistone proteinnovel pathogennovel therapeutic approachnovel therapeutic interventionnovel therapeutic strategiesnovel therapy approachontogenypathogenpathogenic bacteriapathophysiologypathwayprotein expressionprotein protein interactionresponsesocial roletherapeutically effectivetranscriptional differencestranscriptional profiletranscriptional signaturetranscriptometranscriptome sequencingtranscriptomic sequencingtype 4 secretion systemundergradundergraduateundergraduate student
Description preview
1 Legionella pneumophila is an opportunist pathogen that infects an immune-compromised host and causes
2 inflammatory pneumonia in the lungs termed as legionnaire’s disease. L. pneumophila infects alveolar
3 macrophages within the lungs and using a type IV secretion system, discharges an array of more than 300
4 proteins called effectors that…
🔒
Start 7-day free trial — $29.99/mo →Full details available on the Agency plan
Unlock the complete grant description, eligibility criteria, contract value, evaluation details and apply link — plus alerts, pipeline tracking, and CSV export.
Agency Plan
7-day free trialUnlock procurement & grants
Upgrade to access active tenders from World Bank, UNDP, ADB and more — with email alerts and pipeline tracking.
$29.99 / month
- 🔔Email alerts for new matching tenders
- 🗂️Track tenders in your pipeline
- 💰Filter by contract value
- 📥Export results to CSV
- 📌Save searches with one click