grant
Role of EphA1/A2 domain-domain and -membrane interactions for receptor specificity and Blood Brain Barrier dysfunction
Organization CASE WESTERN RESERVE UNIVERSITYLocation CLEVELAND, UNITED STATESPosted 1 Sept 2024Deadline 30 Jun 2028
NIHUS FederalResearch GrantFY2025AD dementiaADAM10 proteinAdaptor ProteinAdaptor Protein GeneAdaptor Signaling ProteinAdaptor Signaling Protein GeneAdhesionsAffectAlzheimer Type DementiaAlzheimer beta-ProteinAlzheimer disease dementiaAlzheimer sclerosisAlzheimer syndromeAlzheimer'sAlzheimer's Amyloid beta-ProteinAlzheimer's DiseaseAlzheimer's amyloidAlzheimers DementiaAmyloid Alzheimer's Dementia Amyloid ProteinAmyloid Beta-PeptideAmyloid Protein A4Amyloid beta-ProteinAmyloid βAmyloid β-PeptideAmyloid β-ProteinAssayAβBehaviorBindingBioassayBiochemicalBiological AssayBiophysicsBlood - brain barrier anatomyBlood brain barrier dysfunctionBlood-Brain BarrierC-terminalCancersCek-8 KinaseCell BodyCell Communication and SignalingCell LocomotionCell MigrationCell MovementCell SignalingCell surfaceCellsCellular MembraneCellular MigrationCellular MotilityChargeCholesterolCold-Insoluble GlobulinsComplexCoupledDNA mutationDataDegenerative Neurologic DisordersDimerizationDiseaseDisorderDrug resistanceEPH- and ELK-Related Tyrosine KinaseEPH-and ELK-Related KinaseEph Family ReceptorsEph Receptor Tyrosine KinaseEph ReceptorsEph-A4 Receptor Tyrosine KinaseEphA4 ProteinEphA4 ReceptorEphrin Receptor A4Ephrin ReceptorsEphrin Type-A Receptor 8Ephrin Type-A Receptor 8 PrecursorFN1Fibronectin 1Fibronectin ReceptorFibronectin ReceptorsFibronectinsFluorescenceGenetic ChangeGenetic defectGenetic mutationHemato-Encephalic BarrierINPPL1INPPL1 geneInositol Polyphosphate Phosphatase-Like 1Intracellular Communication and SignalingInvadedIschemic StrokeKinasesKnowledgeLETS ProteinsLarge External Transformation-Sensitive ProteinLengthLigandsLipid BilayersMMPsMalignant NeoplasmsMalignant TumorMapsMatrix MetalloproteinasesMembraneMetastasisMetastasizeMetastatic LesionMetastatic MassMetastatic NeoplasmMetastatic TumorMethodsMolecularMolecular ConfigurationMolecular ConformationMolecular InteractionMolecular Modeling Nucleic Acid BiochemistryMolecular Modeling Protein/Amino Acid BiochemistryMolecular ModelsMolecular StereochemistryMutationNeoplasm MetastasisNerve CellsNerve UnitNervous System Degenerative DiseasesNeural CellNeural Degenerative DiseasesNeural degenerative DisordersNeurocyteNeurodegenerative DiseasesNeurodegenerative DisordersNeurologic Degenerative ConditionsNeuronsOpsonic GlycoproteinOpsonic alpha(2)SB GlycoproteinOrganismPIP2PTK ReceptorsPathogenicityPeptide DomainPeptidesPhosphatidylinositol 4,5-BiphosphatePhosphatidylinositol 4,5-DiphosphatePhosphatidylinositol-4,5-BisphosphatePhosphorylationPhosphotransferase GenePhosphotransferasesPlayPrimary Senile Degenerative DementiaProcessProtein DimerizationProtein DomainsProtein FamilyProtein FragmentProtein PhosphorylationProtein Tyrosine KinaseProtein Tyrosine Kinase EEKProteinsPtIns 4,5-P2PtdInsP2Receptor ProteinReceptor Protein-Tyrosine KinasesReceptor Tyrosine Kinase GeneReportingResearchRoleSAM DomainSH2 DomainsSH2-Containing Inositol Phosphatase 2SHIP2Secondary NeoplasmSecondary TumorSek-1 Receptor Tyrosine KinaseSerine/Threonine PhosphorylationSignal TransductionSignal Transduction SystemsSignalingSingle Crystal DiffractionSpecificitySterile Alpha MotifSterile Alpha Motif DomainStimulusStructureTM DomainTertiary Protein StructureTestingTherapeutic AgentsTransmembrane DomainTransmembrane Receptor Protein Tyrosine KinaseTransmembrane RegionTransphosphorylasesTyrosineTyrosine KinaseTyrosine Kinase Linked ReceptorsTyrosine Kinase ReceptorsTyrosine-Protein Kinase Receptor EEKTyrosine-Specific Protein KinaseTyrosylprotein KinaseVascular DiseasesVascular DisorderX Ray CrystallographiesX-Ray CrystallographyX-Ray Diffraction CrystallographyX-Ray/Neutron CrystallographyXray Crystallographya beta peptideabetaadapter proteinalpha 2-Surface Binding Glycoproteinamyloid betaamyloid-b proteinaxon growth cone guidanceaxon guidancebeta amyloid fibrilbiological signal transductionbiophysical foundationbiophysical principlesbiophysical sciencesblood vessel developmentblood vessel disorderblood vessel formationbloodbrain barriercancer metastasiscell motilityconformationconformationalconformational stateconformationallyconformationsdegenerative diseases of motor and sensory neuronsdegenerative neurological diseasesdiagnostic developmentdimerdrug resistanterythropoietin-producing human hepatoma receptorexperimentexperimental researchexperimental studyexperimentsextracellularfunctional mimicsgamma secretasegamma secretase complexgenome mutationhydroxyaryl protein kinaseinsightlipid bilayer membraneliving systemmalignancymembrane modelmembrane structuremigrationmimeticsmolecular modelingneoplasm/cancerneurodegenerative illnessneuronalnovelpreferenceprimary degenerative dementiaprotein purificationprotein structureprotein structuresproteins structurereceptorreceptor functionresistance to Drugresistant to Drugsenile dementia of the Alzheimer typesocial rolesoluble amyloid precursor proteinsrc Homology Region 2 Domaintargeted drug therapytargeted drug treatmentstargeted therapeutictargeted therapeutic agentstargeted therapytargeted treatmenttumor cell metastasistyrosyl protein kinasevascular dysfunctionvasculopathyγ-secretase
Description preview
Ligand activation of Eph receptors plays a decisive role in cell migration during blood vessel formation and
neuronal axon guidance. Eph receptors can also signal independently of ligands, whereby the migration- and
adhesion-repulsive signaling shifts to a pro-migratory stimulus that contributes to metastasis and drug
resistance in various…
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