grant
Role of CASP-11 in SARS-CoV-2-induced lung pathologies and long-term immune protection
Organization OHIO STATE UNIVERSITYLocation Columbus, UNITED STATESPosted 10 Apr 2024Deadline 31 Mar 2029
NIHUS FederalResearch GrantFY20252019 novel corona virus2019 novel coronavirus2019-nCoV2019-nCoV vaccine2019-nCoV variant2019-nCoV variant forms2019-nCoV variant strainsAffectAlimentary CanalAntibodiesB blood cellsB cellB cellsB-CellsB-LymphocytesB-cellBacterial InfectionsBlood Coagulation DisordersBlood SampleBlood specimenBody TissuesBrainBrain Nervous SystemCASP11CASP4CASP4 geneCOVID infected patientCOVID patientCOVID positive patientCOVID-19COVID-19 antibodyCOVID-19 immunityCOVID-19 infected patientCOVID-19 infectionCOVID-19 patientCOVID-19 positive patientCOVID-19 therapyCOVID-19 treatmentCOVID-19 vaccineCOVID-19 variantCOVID-19 variant formsCOVID-19 variant strainsCOVID-19 virusCOVID-19 virus infectionCOVID19 infectionCOVID19 patientCOVID19 positive patientCOVID19 virusCV-19Cardiovascular DiseasesCaspaseCaspase GeneCell BodyCell DeathCell FunctionCell LocomotionCell MigrationCell MovementCell PhysiologyCell ProcessCell-Death ProteaseCellsCellular FunctionCellular MigrationCellular MotilityCellular PhysiologyCellular ProcessCessation of lifeClinicalCoV-2CoV2Coagulation DisorderCoagulopathyCoronavirus Infectious Disease 2019Cysteine EndopeptidasesCysteine ProteaseCysteine ProteinasesDataDeathDevelopmentDiabetes MellitusDigestive TractDiseaseDisease OutcomeDisorderEncephalonEndotheliumEnsureEnvironmentExhibitsFutureGI TractGastrointestinal DiseasesGastrointestinal TractGastrointestinal tract structureGenerationsGoalsHeightHematologyHospital AdmissionHospitalizationHumanICE and CED3 Homolog 2ICE-like proteaseICH-2IgAImmuneImmune Cell ActivationImmune responseImmune systemImmunesImmunityImmunoglobulin AImpairmentInfectionInfectious AgentInflammasomeInflammationInflammatoryInflammatory ResponseInnate Immune ResponseKO miceKidney DiseasesKnock-out MiceKnockout MiceLong COVIDLong COVID-19Long coronavirus diseaseLong coronavirus disease 2019LungLung ParenchymaLung Respiratory SystemLung TissueLung damageLymphatic TissueLymphoid TissueMOF syndromeMeasuresMediatingMental HealthMental HygieneMiceMice MammalsModern ManMolecularMouse Homolog of Caspase 11MucosaMucosal ImmunityMucosal TissueMucous MembraneMultiple Organ Dysfunction SyndromeMultiple Organ FailureMurineMusMusculoskeletal DiseasesNasopharynxNatureNephropathyNeurologicNeurologicalNon-Polyadenylated RNANull MouseOrganPathologyPathway interactionsPatientsPersonsPlayProductionPrognosisPsychological HealthPulmonary PathologyRNARNA Gene ProductsRNA SeqRNA sequencingRNAseqRelaxationRenal DiseaseReportingRhinopharynxRibonucleic AcidRiskRoleSARS corona virus 2SARS-CO-V2SARS-COVID-2SARS-CoV-2SARS-CoV-2 antibodySARS-CoV-2 immunitySARS-CoV-2 infected patientSARS-CoV-2 infectionSARS-CoV-2 patientSARS-CoV-2 positive patientSARS-CoV-2 therapySARS-CoV-2 treatmentSARS-CoV-2 vaccineSARS-CoV-2 variantSARS-CoV-2 variant formsSARS-CoV-2 variant strainsSARS-CoV2SARS-CoV2 infectionSARS-associated corona virus 2SARS-associated coronavirus 2SARS-coronavirus-2SARS-coronavirus-2 vaccineSARS-related corona virus 2SARS-related coronavirus 2SARSCoV2SepsisSevere Acute Respiratory Coronavirus 2Severe Acute Respiratory Distress Syndrome CoV 2Severe Acute Respiratory Distress Syndrome Corona Virus 2Severe Acute Respiratory Distress Syndrome Coronavirus 2Severe Acute Respiratory Syndrome CoV 2Severe Acute Respiratory Syndrome CoV 2 vaccineSevere Acute Respiratory Syndrome-associated coronavirus 2Severe Acute Respiratory Syndrome-related coronavirus 2Severe acute respiratory syndrome associated corona virus 2Severe acute respiratory syndrome coronavirus 2Severe acute respiratory syndrome coronavirus 2 immunitySevere acute respiratory syndrome coronavirus 2 infectionSevere acute respiratory syndrome coronavirus 2 vaccineSevere acute respiratory syndrome related corona virus 2SeveritiesSeverity of illnessShapesSiteStructure of parenchyma of lungSubcellular ProcessSymptomsSyndromeT cell responseT-CellsT-LymphocyteTestingThrombosisTissuesTransferaseTransferase GeneTransmissionTravelVaccineeVaccinesViralViral BurdenViral LoadViral Load resultVirusVirus ReplicationWuhan coronavirusacute COVID-19acute SARS-CoV-2 infectionacute phase of COVID-19acute phase of SARS-CoV-2 infectionadaptive immune responseadaptive immunityafter COVID-19 infectionafter SARS-CoV-2 infectionafter SARS-CoV2 infectionafter infection by SARS-CoV-2after severe acute respiratory distress syndrome CoV-2 infectionalimentary tractantibody against COVID-19antibody against SARS-CoV-2antibody against coronavirus disease 2019antibody against severe acute respiratory syndrome coronavirus 2antibody to COVID-19antibody to SARS-CoV-2antibody to coronavirus disease 2019antibody to severe acute respiratory syndrome coronavirus 2bacteria infectionbacterial diseasebleeding disordercardiovascular disordercell motilitychronic COVIDchronic COVID-19chronic novel coronavirus disease 2019clotting disordercoronavirus disease 2019coronavirus disease 2019 antibodycoronavirus disease 2019 immunitycoronavirus disease 2019 infected patientcoronavirus disease 2019 infectioncoronavirus disease 2019 patientcoronavirus disease 2019 positive patientcoronavirus disease 2019 therapycoronavirus disease 2019 treatmentcoronavirus disease 2019 vaccinecoronavirus disease 2019 variantcoronavirus disease 2019 variant formscoronavirus disease 2019 variant strainscoronavirus disease 2019 viruscoronavirus disease infected patientcoronavirus disease patientcoronavirus disease positive patientcoronavirus disease-19coronavirus disease-19 patientcoronavirus disease-19 vaccinecoronavirus disease-19 viruscoronavirus infectious disease-19coronavirus patientcystein proteasecystein proteinasecysteine endopeptidasecytokinecytokine release syndromecytokine stormdeath riskdevelop a vaccinedevelop vaccinesdevelopment of a vaccinedevelopmentaldiabetesdigestive canaldisease severityfollowing COVID-19 infectionfollowing SARS-CoV-2 infectionfollowing SARS-CoV2 infectionfollowing infection by SARS-CoV-2following severe acute respiratory distress syndrome CoV-2 infectiongastrointestinal disorderhCoV19host responseimmune activationimmune check pointimmune checkpointimmune system responseimmunecheckpointimmunity against COVID-19immunity against SARS-CoV-2immunity against Severe acute respiratory syndrome coronavirus 2immunity against coronavirus disease 2019immunity to COVID-19immunity to SARS-CoV-2immunity to Severe acute respiratory syndrome coronavirus 2immunity to coronavirus disease 2019immunoresponseimprovedinfected with COVID-19infected with COVID19infected with SARS-CoV-2infected with SARS-CoV2infected with coronavirus disease 2019infected with severe acute respiratory syndrome coronavirus 2infectious organismkidney disorderlife-threatening COVIDlife-threatening COVID-19life-threatening SARS-CoV-2life-threatening coronavirus diseaselife-threatening coronavirus disease 2019life-threatening severe acute respiratory syndrome coronavirus 2long haul COVIDlong haul COVID-19long haul coronavirus diseaselong haul coronavirus disease 2019long-hauler COVIDlong-hauler COVID-19long-hauler coronavirus disease 2019long-hauler syndromelong-term COVIDlong-term COVID-19long-term coronavirus diseaselong-term coronavirus disease 2019lung injurylung pathologymembermortality riskmouse modelmultiorgan failuremultiple organ system failuremurine modelmusculoskeletal disordernCoV vaccinenCoV-19 vaccinenCoV19 vaccinenCoV2nasal swabnasopharnygealnecrocytosisnew therapeutic approachnew therapeutic interventionnew therapeutic strategiesnew therapy approachesnew treatment approachnew treatment strategynovel therapeutic approachnovel therapeutic interventionnovel therapeutic strategiesnovel therapy approachpandemicpandemic diseasepathogenpathwaypatient infected with COVIDpatient infected with COVID-19patient infected with SARS-CoV-2patient infected with coronavirus diseasepatient infected with coronavirus disease 2019patient infected with severe acute respiratory syndrome coronavirus 2patient with COVIDpatient with COVID-19patient with COVID19patient with SARS-CoV-2patient with coronavirus diseasepatient with coronavirus disease 2019patient with severe acute respiratory distress syndrome coronavirus 2persistent COVID-19post COVID syndromepost COVID-19 syndromepost SARS-CoV-2 infectionpost acute COVID syndromepost acute COVID-19post acute COVID-19 syndromepost acute SARS-CoV-2post acute coronavirus disease 2019post acute coronavirus disease 2019 syndromepost acute coronavirus disease syndromepost acute severe acute respiratory syndrome coronavirus 2post coronavirus disease 2019 syndromepost coronavirus disease syndromepost-acute phases of COVID-19preventpreventingprevious COVID-19 infectionprevious SARS-CoV-2 infectionprevious SARS-CoV2 infectionprevious severe acute respiratory distress syndrome CoV-2 infectionprior COVID-19 infectionprior SARS-CoV-2 infectionprior SARS-CoV2 infectionprior severe acute respiratory distress syndrome CoV-2 infectionprogramsprolonged COVID-19 symptomspulmonarypulmonary damagepulmonary injurypulmonary tissue damagepulmonary tissue injuryrenal disorderrespiratoryresponseserious COVIDserious COVID-19serious SARS-CoV-2serious coronavirus diseaseserious coronavirus disease 2019serious severe acute respiratory syndrome coronavirus 2severe COVIDsevere COVID-19severe COVID19severe SARS-CoV-2severe acute respiratory syndrome coronavirus 2 antibodysevere acute respiratory syndrome coronavirus 2 infected patientsevere acute respiratory syndrome coronavirus 2 patientsevere acute respiratory syndrome coronavirus 2 positive patientsevere acute respiratory syndrome coronavirus 2 therapysevere acute respiratory syndrome coronavirus 2 treatmentsevere acute respiratory syndrome coronavirus 2 variantsevere acute respiratory syndrome coronavirus 2 variant formssevere acute respiratory syndrome coronavirus 2 variant strainssevere coronavirus diseasesevere coronavirus disease 19severe coronavirus disease 2019severe severe acute respiratory syndrome coronavirus 2social rolestemthrombotic diseasethrombotic disorderthymus derived lymphocytetranscriptome sequencingtranscriptomic sequencingtransmission processtreat COVID-19treat SARS-CoV-2treat coronavirus disease 2019treat severe acute respiratory syndrome coronavirus 2vaccinated individualvaccinated participantvaccinated patientvaccinated personvaccinated subjectvaccine against 2019-nCovvaccine against COVID-19vaccine against SARS-CoV-2vaccine against SARS-coronavirus-2vaccine against Severe Acute Respiratory Syndrome CoV 2vaccine against Severe acute respiratory syndrome coronavirus 2vaccine candidates against SARS-CoV-2vaccine developmentvaccine for novel coronavirusvaccines preventing COVIDvaccines to prevent COVIDvariants of concernviral multiplicationviral replicationviral transmissionvirus multiplicationvirus transmission
Description preview
PROJECT 1 - ABSTRACT
The rapid development of SARS-CoV-2 vaccines has helped ease most of the restrictions in place during the
height of the pandemic to limit transmission of the virus. Unfortunately, the adaptive immunity (i.e., antibody and
T cell responses) induced by current vaccines declines rapidly, thus requiring frequent boosts. Most…
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