grant
Role of branched-chain fatty acids in physiology and virulence of Staphylococcus aureus
Organization GEORGETOWN UNIVERSITYLocation WASHINGTON, UNITED STATESPosted 23 Jul 2025Deadline 30 Jun 2029
NIHUS FederalResearch GrantFY2025Acid-Thiol LigasesAcyl CoA SynthetasesAcyl Coenzyme A SynthetasesAffinityAttenuatedBacteriaBacterial InfectionsBindingBiochemicalBiologicalBlood NeutrophilBlood Polymorphonuclear NeutrophilBranched-Chain Amino AcidsCell BodyCell Communication and SignalingCell DeathCell SignalingCellsChimera ProteinChimeric ProteinsChronicCo A LigasesCo-cultureCocultivationCocultureCoculture TechniquesCoenzyme A LigasesCoenzyme A SynthetasesCollaborationsComplexDimerizationDiseaseDisease OutcomeDisorderE faecalisE. faecalisEnabling FactorsEnterococcus faecalisEnvironmentEnzyme GeneEnzymesEssential Fatty AcidsExhibitsExternal DomainExtracellular DomainFRETFamilyFatty AcidsFeedsFirmicutesFluorescence Resonance Energy TransferFusion ProteinFörster Resonance Energy TransferGene TargetingGenesGeneticGenus staphylococcusGoalsHemalysinsHemolysinHumanIn VitroInfectionInfectious Skin DiseasesIntracellular Communication and SignalingIsoleucineKeto AcidsKinasesKnowledgeL-ValineLabelLaboratoriesLeucineLiquid substanceMarrow NeutrophilMass Photometry/Spectrum AnalysisMass SpectrometryMass SpectroscopyMass SpectrumMass Spectrum AnalysesMass Spectrum AnalysisMembraneMetabolicMiceMice MammalsMicrobeModelingModern ManMolecularMolecular InteractionMurineMusNamesNeutrophilic GranulocyteNeutrophilic LeukocyteOrganismP aeruginosaP. aeruginosaPathogenicityPathogenicity FactorsPathway interactionsPatient outcomePatient-Centered OutcomesPatient-Focused OutcomesPenetrationPeptidesPhasePhenotypePhosphatidesPhospholipidsPhosphotransferase GenePhosphotransferasesPhysiologyPolymersPolymorphonuclear CellPolymorphonuclear LeukocytesPolymorphonuclear NeutrophilsProcessProductionProtein DimerizationProteinsPseudomonas aeruginosaPseudomonas pyocyaneaR peptideResearchRoleRouteS aureusS faecalisS. aureusS. faecalisSignal TransductionSignal Transduction SystemsSignalingSoft Tissue InfectionsStaph aureusStaphylococcusStaphylococcus aureusStreptococcus Group DStreptococcus faecalisSystemTestingTherapeuticToxic effectToxicitiesTransphosphorylasesValineVirulenceVirulence FactorsWound InfectionWound modelsantibiotic toleranceattenuateattenuatesbacteria infectionbacterial diseasebiologicbiological signal transductionbranched amino acidsbranched chain fatty acidchronic skin woundchronic woundco-infectioncoinfectioncombatcutaneous infectionfluidhistidine kinasein vivoinfected skininfected woundinsightinsoluble aggregateinterestketoacidlipidomicsliquidliving systemmembrane biogenesismembrane structuremouse modelmurine modelmutantnamenamednamingnecrocytosisneutrophilnew drug treatmentsnew drugsnew pharmacological therapeuticnew therapeutic approachnew therapeutic interventionnew therapeutic strategiesnew therapeuticsnew therapynew therapy approachesnew treatment approachnew treatment strategynext generation therapeuticsnovelnovel drug treatmentsnovel drugsnovel pharmaco-therapeuticnovel pharmacological therapeuticnovel therapeutic approachnovel therapeutic interventionnovel therapeutic strategiesnovel therapeuticsnovel therapynovel therapy approachopportunistic pathogenpathogenpathogenicity genepathwaypatient oriented outcomespolymerpolymericpreventpreventingpromoterpromotorprotein aggregateprotein aggregationprotein protein interactionprotein-histidine kinaseresponsesegregationskin infectionsocial rolesynergismthiokinasetissue woundtolerance to antibioticstolerate antibioticsvirulence genevirulent genewoundwound healing modelswoundingwounds
Description preview
7. Project Summary/Abstract
While some bacterial infections are caused by a single species, we now know that most infections are
polymicrobial in origin. We know that the activities of these species are often synergistic, as interactions between
species enhances virulence, persistence, and tolerance to antibiotics. The end result is patient…
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