grant
RNA-mediated endotheliopathy in diabetic vasculopathy
Organization BECKMAN RESEARCH INSTITUTE/CITY OF HOPELocation DUARTE, UNITED STATESPosted 1 Jul 2024Deadline 30 Jun 2031
NIHUS FederalResearch GrantFY202521+ years oldAddressAdultAdult HumanAutomobile DrivingAwardBiologyBlood VesselsCell FunctionCell PhysiologyCell ProcessCellular FunctionCellular PhysiologyCellular ProcessChromatinDNA TherapyDevelopmentDiabetes MellitusDiseaseDisorderEndothelial CellsEndotheliumEpigeneticEpigenetic ChangeEpigenetic MechanismEpigenetic ProcessFunctional RNAFundingGene Transfer ClinicalGenetic InterventionGoalsImpairmentInvestigatorsKnowledgeMediatingMediatorMedicalMemoryMetabolicMetabolic DiseasesMetabolic DisorderMicroRNAsMissionModificationNHLBINational Heart, Lung, and Blood InstituteNon-Polyadenylated RNANoncoding RNANontranslated RNAPainPainfulPatientsPeripheral arterial diseasePlayPopulationPredispositionRNARNA Gene ProductsResearchResearch PersonnelResearchersRibonucleic AcidRoleSightSubcellular ProcessSusceptibilityTestingTherapeuticThesaurismosisUntranslated RNAVascular DiseasesVascular DisorderVascular regenerationVisionadulthoodblood vessel disorderdetermine efficacydevelopmentaldiabetesdiabeticdrivingeffective therapyeffective treatmentefficacy analysisefficacy assessmentefficacy determinationefficacy evaluationefficacy examinationendothelial dysfunctionepigenetic memoryepigeneticallyepigenomeepitranscriptomeevaluate efficacyexamine efficacyexperiencegene repair therapygene therapygene-based therapygenetic therapygenomic therapyhigh riskinnovateinnovationinnovativeinnovative technologiesinsightmetabolism disordermiRNAnano medicinalnano medicinenano particlenano-sized particlenanomedicinalnanomedicinenanoparticlenanosized particlenew drug treatmentsnew drugsnew pharmacological therapeuticnew therapeuticsnew therapynext generation therapeuticsnoncodingnovelnovel drug treatmentsnovel drugsnovel pharmaco-therapeuticnovel pharmacological therapeuticnovel therapeuticsnovel therapyperipheral artery diseaserestorationsocial roletargeted drug therapytargeted drug treatmentstargeted therapeutictargeted therapeutic agentstargeted therapytargeted treatmenttherapeutic targetvascularvascular dysfunctionvascular inflammationvasculopathyvisual function
Description preview
Project Summary
More than 10% of the global adult population currently lives with diabetes mellitus (DM) and are
experiencing or at higher risk for various diabetic vasculopathies such as peripheral artery disease (PAD).
Despite available treatment, many patients with DM continue to develop diabetic vasculopathy, highlighting the
urgent need for…
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