grant
RNA folding and catalysis at the interface of biophysics and genomics
Organization PENNSYLVANIA STATE UNIVERSITY, THELocation UNIVERSITY PARK, UNITED STATESPosted 1 May 2018Deadline 30 Apr 2029
NIHUS FederalResearch GrantFY2025BindingBiochemicalBioinformaticsBiologicalBiologyBiophysicsCatalysisCatalytic RNACell BodyCellsChargeDNA mutationDevelopmentEnzyme GeneEnzyme PrecursorsEnzymesEquilibriumExonsFluorescenceGene Action RegulationGene Expression RegulationGene RegulationGene Regulation ProcessGenesGenetic ChangeGenetic defectGenetic mutationGenomicsGoalsHealthHumanKineticsMethodsModern ManMolecularMolecular InteractionMutationNGS MethodNGS systemNon-Polyadenylated RNAOligoOligonucleotidesPathway interactionsProenzymesRNARNA FoldingRNA Gene ProbesRNA Gene ProductsRNA ProbesRNA targeting drugRNA targeting therapeuticsRNA-targeting therapyRibonucleic AcidRibozymesSightStructureTemperatureTherapeuticVisionWorkZymogensbalancebalance functionbasebasesbiologicbiophysical foundationbiophysical principlesbiophysical scienceschemical informaticscheminformaticsdevelopmentalgenome mutationin vivoinsightloss of functionnew technologynext gen sequencingnext generation sequencingnextgen sequencingnovelnovel technologiesnucleobaseoligospathwaytautomertime usetoolvisual function
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Abstract
The overall vision of the Bevilacqua lab is that human health can be advanced by combining
holistic genomic and detailed molecular views of fundamental problems in RNA biology. Over the
next five years, the work outlined in this MIRA will advance RNA folding and catalysis under in
vivo and in vivo-like conditions using a combination of…
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