🗂️
Archived grant — no longer open
This grant has closed and is kept as a historical reference. Browse current grants for active opportunities.
grant
RNA decay in amyotrophic lateral sclerosis and frontotemporal lobar degeneration
Organization UNIVERSITY OF MICHIGAN AT ANN ARBORLocation ANN ARBOR, UNITED STATESPosted 1 Aug 2016Deadline 30 Apr 2026 ⚠️
NIHUS FederalResearch GrantFY2025ALS patientsAdenosineAffectAmyotrophic Lateral SclerosisAmyotrophic Lateral Sclerosis Motor Neuron DiseaseAmyotrophic Lateral Sclerosis patientsAmyotrophic lateral sclerosis and frontotemporal degenerationAmyotrophic lateral sclerosis and frontotemporal dementiaAutoregulationBindingBinding ProteinsC9ORF72CategoriesCell BodyCellsCytoplasmDNA mutationDataDegenerative Neurologic DisordersDepositDepositionDiseaseDisorderEquilibriumFTD/ALSFTLDFTLD/ALSFUS ProteinFailureFamilial diseaseFamilyFrontal Temporal Lobar DegenerationFrontotemporal Lobar Degeneration/Amyotrophic lateral sclerosisFrontotemporal Lobar DegenerationsFrontotemporal variety lobar degenerationFundingFusion Protein in Myxoid LiposarcomaGehrig's DiseaseGene TranscriptionGenesGeneticGenetic ChangeGenetic TranscriptionGenetic defectGenetic mutationGoalsHealthHomeostasisHumanHypermethylationImpairmentIndividualInduced pluripotent stem cell derived neuronsInterruptionIntervening SequencesIntronsLeadLigand Binding ProteinLigand Binding Protein GeneLou Gehrig DiseaseMapsMediatingMedulla SpinalisMessenger RNAMethylationMicroscopyModelingModern ManModificationMolecular InteractionMutationNerve CellsNerve DegenerationNerve UnitNervous System Degenerative DiseasesNeural CellNeural Degenerative DiseasesNeural degenerative DisordersNeurocyteNeurodegenerative DiseasesNeurodegenerative DisordersNeurologic Degenerative ConditionsNeuron DegenerationNeuron from iPSCNeuron from induced pluripotent stem cellsNeuronal DysfunctionNeuronsNitrogenNon-Polyadenylated RNANuclear ProteinNuclear RNAPOMp75 ProteinPathogenesisPathologicPathway interactionsPatientsPatternPb elementPhysiological HomeostasisProcessPropertyProtein BindingProteinsProteomeQuality ControlRNARNA BindingRNA DecayRNA ExpressionRNA Gene ProductsRNA HelicaseRNA InstabilityRNA SplicingRNA StabilityRNA boundRNA chemical synthesisRNA synthesisRNA-Binding Protein FUSRNA-Binding ProteinsReaderRiboTagRibonucleic AcidRibosomal ProteinsSamplingSpinal CordSplicingSurvival AnalysesSurvival AnalysisTAR DNA binding protein 43 kDa pathologyTAR DNA binding protein 43 pathologyTAR DNA binding protein of 43 proteinopathyTAR DNA-binding protein 43TDP-43TDP43TDP43 associated neurodegenerationTDP43 associated neurodegenerative diseaseTDP43 associated pathologiesTDP43 induced neurodegenerationTDP43 neurodegenerationTDP43 neurodegenerative diseaseTDP43 neuropathologyTDP43 pathogenesisTDP43 pathologyTDP43 proteinopathyTDP43 related neurodegenerationTDP43 related pathologyTLS ProteinTestingTherapeuticToxic effectToxicitiesTrans active response DNA binding protein 43 pathologyTrans active response DNA binding protein of 43 kDa proteinopathyTranscriptTranscriptionTranslationsTranslocated in Liposarcoma ProteinWorkamyotrophic lateral sclerosis with frontotemporal dementiaamyotrophic lateral sclerosis/FTLDamyotrophic lateral sclerosis/frontotemporal dementiaamyotrophic lateral sclerosis/ftdbalancebalance functionbound proteincell typechromosome 9 open reading frame 72degenerative diseases of motor and sensory neuronsdegenerative neurological diseasesfamilial disorderfrontotemporal dementia-amyotrophic lateral sclerosisfrontotemporal lobar dementia amyotrophic lateral sclerosisgenome mutationheavy metal Pbheavy metal leadhnRNP P2iPS neuronsiPSC derived-neuronsinduced pluripotent stem cell neuronsknock-downknockdownmRNAmutantnerve cell deathnerve cell lossneural degenerationneural dysfunctionneurodegenerationneurodegenerativeneurodegenerative illnessneurological degenerationneuron cell deathneuron cell lossneuron deathneuron lossneuronalneuronal cell deathneuronal cell lossneuronal deathneuronal degenerationneuronal lossneuronal survivalneurons derived from induced pluripotent stem cellsneurons differentiated from induced pluripotent stem cellsneuroprotectionneuroprotectivenoveloverexpressoverexpressionparticlepathwaypreventpreventingprotein TDP-43protein TDP43protein functionresponsesingle moleculetherapeutically effectivetrans active response DNA binding protein 43 kDa pathologytrans active response DNA binding protein 43 proteinopathytranslation
Applications closed.
Description preview
RNA decay is a critical component of RNA homeostasis. Transcriptionally active cells such as neurons
have developed intricate pathways for regulating RNA turnover and balancing this process with RNA synthesis.
During the initial funding period, we uncovered widespread abnormalities in RNA stability in cells from individuals
with amyotrophic…
🔒
Start 7-day free trial — $29.99/mo →Full details available on the Agency plan
Unlock the complete grant description, eligibility criteria, contract value, evaluation details and apply link — plus alerts, pipeline tracking, and CSV export.
Agency Plan
7-day free trialUnlock procurement & grants
Upgrade to access active tenders from World Bank, UNDP, ADB and more — with email alerts and pipeline tracking.
$29.99 / month
- 🔔Email alerts for new matching tenders
- 🗂️Track tenders in your pipeline
- 💰Filter by contract value
- 📥Export results to CSV
- 📌Save searches with one click