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Reversing Skeletal Aging by Restoring Functional Skeletal Stem Cell Diversity
Organization UNIVERSITY OF CALIFORNIA AT DAVISLocation DAVIS, UNITED STATESPosted 1 Apr 2021Deadline 31 Dec 2025 ⚠️
NIHUS FederalResearch GrantFY2025ATAC sequencingATAC-seqATACseqAddressAgingAmericanAminesAnatomic SitesAnatomic structuresAnatomyAssay for Transposase-Accessible Chromatin using sequencingAutoregulationBone DiseasesBone FormationBone ResorptionCartilageCartilaginous TissueCell BodyCell CommunicationCell CompartmentationCell CompartmentationsCell InteractionCell LineageCell-to-Cell InteractionCellsDeath RateDefectDevelopmentDiagnosticDysfunctionElderlyEnvironmentEpigeneticEpigenetic ChangeEpigenetic MechanismEpigenetic ProcessExtremitiesFractureFrequenciesFunctional disorderHealthHeterogeneityHip FracturesHomeostasisImpairmentIn VitroIncidenceInjuryInstitutionLabelLimb structureLimbsLinkMediatingMedicalMethodsMiceMice MammalsModernizationMolecularMorbidityMorbidity - disease rateMurineMusNon-TrunkOsteoclastic Bone LossOsteogenesisOsteoporosisPathway interactionsPhasePhysiological HomeostasisPhysiopathologyPreventiveProgenitor CellsProteinsProteomicsPublic HealthReceptor ProteinRegenerative capacityReportingResearchRoleSignal PathwaySocietiesSourceSpatial DistributionTestingTherapeuticTimeTransplantationadult progenitoradult stem celladvanced ageage associatedage associated alterationsage associated changesage associated functional declineage correlatedage correlated alterationsage correlated changesage dependentage dependent alterationsage dependent changesage dependent functional declineage induced alterationsage induced changesage induced loss of functionage linkedage relatedage related alterationsage related changesage related functional declineage specificage specific alterationsage specific changesage-related loss of functionagedaged boneaging associated alterationsaging associated changesaging associated functional declineaging correlated alterationsaging correlated changesaging dependent alterationsaging dependent changesaging induced alterationsaging induced changesaging induced functional declineaging related alterationsaging related changesaging related functional declineaging specific alterationsaging specific changesalterations with ageamineassay for transposase accessible chromatin followed by sequencingassay for transposase accessible chromatin seqassay for transposase accessible chromatin sequencingassay for transposase-accessible chromatin with sequencingbonebone agingbone disorderbone fracturebone tissue formationcell imagingcellular imagingchanges with agedevelopmentalepigeneticallyexperimentexperimental researchexperimental studyexperimentsfunctional decline due to agingfunctional decline with agefunctional decline with agingfunctional loss with agingfunctional restorationgeriatricin vitro Assayin vivoinjurieslong bonemortality ratemortality rationanostringnew drug treatmentsnew drugsnew pharmacological therapeuticnew therapeuticsnew therapynext generation therapeuticsnovelnovel drug treatmentsnovel drugsnovel pharmaco-therapeuticnovel pharmacological therapeuticnovel therapeuticsnovel therapypathophysiologypathwayprogenitor agingprogenitor cell agingprogenitor cell poolprogenitor cell populationprogenitor poolprogenitor populationreceptorregeneration abilityregeneration capacityregeneration following injuryregenerativeregenerative approachregenerative strategyregenerative techniquerestore functionrestore functionalityrestore lost functionscRNA sequencingscRNA-seqsenior citizenside effectsingle cell RNA-seqsingle cell RNAseqsingle cell analysissingle cell expression profilingsingle cell transcriptomic profilingsingle-cell RNA sequencingskeletalskeletal diseaseskeletal disorderskeletal progenitorskeletal progenitor cellskeletal stem cellskeletogenesissocial rolesomatic progenitorsomatic stem cellspatial and temporalspatial temporalspatiotemporalstem and progenitor cell populationstem cell agingstem cell poolstem cell populationstem cellstranscriptomicstransplant
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Description preview
Advancing age is tightly linked to the increasing global incidence of skeletal diseases. Osteoporosis poses a major public health threat for over 54 million Americans as it is interrelated with high fracture rates. Osteoporosis related hip fractures are invariably associated with significant morbidity and strikingly, a 58% mortality rate in the…
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