grant
Reverse-engineering a viral Swiss army knife: Crimean-Congo hemorrhagic fever virus glycoprotein functions in assembly, entry, and in vivo pathogenesis
Organization ALBERT EINSTEIN COLLEGE OF MEDICINELocation BRONX, UNITED STATESPosted 15 Aug 2024Deadline 31 Jul 2029
NIHUS FederalResearch GrantFY20252019-nCoV S protein2019-nCoV spike glycoprotein2019-nCoV spike proteinAb-mediated immunityAb-mediated protectionAddressAfricaAnimalsAntibodiesAntibody immunityAntibody protectionAntibody-mediated protectionAntigenic DeterminantsArchitectureAsiaAssayBindingBinding DeterminantsBioassayBiogenesisBiological AssayBleedingBlood VesselsBunyavirusCOVID-19 S proteinCOVID-19 spikeCOVID-19 spike glycoproteinCOVID-19 spike proteinCell BodyCellsClinical Treatment MoabCollaborationsComplementComplement ProteinsComplexCongo VirusCongo hemorrhagic fever virusContainmentCountryCrimean Hemorrhagic Fever VirusCrimean-Congo Hemorrhagic Fever VirusCrimean-Congo hemorrhagic fever orthonairovirusCryo-electron MicroscopyCryoelectron MicroscopyDNA mutationDataDevelopmentDiseaseDisorderElectron CryomicroscopyEndotheliumEngineeringEngineering / ArchitectureEnvironmentEpitope MappingEpitopesEuropeEvolutionFDA approvedFlavivirusFoundationsGeneticGenetic ChangeGenetic defectGenetic mutationGenetic studyGenetics-MutagenesisGlycoproteinsGoalsGroup B ArbovirusHemorrhageHost FactorHost Factor ProteinHu-mABsHumanIn VitroInfectionIntegration Host FactorsLocationMapsMass Photometry/Spectrum AnalysisMass SpectrometryMass SpectroscopyMass SpectrumMass Spectrum AnalysesMass Spectrum AnalysisMediatingMembraneMembrane Protein GeneMembrane ProteinsMembrane-Associated ProteinsModelingModern ManMolecularMolecular ConfigurationMolecular ConformationMolecular InteractionMolecular StereochemistryMonoclonal AntibodiesMutagenesisMutagenesis Molecular BiologyMutationNIAIDNairovirusNational Institute of Allergy and Infectious DiseaseOrigin of LifeOrthobunyavirusOrthoflavivirusOrthonairovirusPathogenesisPathway interactionsPermeabilityProtein EngineeringProteolytic ClippingProteolytic ProcessingRecombinant ProteinsRecombinantsResearchResolutionReverse engineeringRodent ModelRoleSARS-CoV-2 SSARS-CoV-2 S proteinSARS-CoV-2 spikeSARS-CoV-2 spike glycoproteinSARS-CoV-2 spike proteinSeriesSevere acute respiratory syndrome coronavirus 2 S proteinSevere acute respiratory syndrome coronavirus 2 spike glycoproteinSevere acute respiratory syndrome coronavirus 2 spike proteinSpecificityStructureSurfaceSurface ProteinsTestingToxinVSVVaccinesVesicular Stomatitis VirusVesicular stomatitis Indiana virusViralViral DiseasesViral PathogenesisVirionVirusVirus AssemblyVirus DiseasesVirus ParticleVirus-like particleantibody-mediated immunityblood losscomplementationconformationconformationalconformational stateconformationallyconformationscoronavirus disease 2019 S proteincoronavirus disease 2019 spike glycoproteincoronavirus disease 2019 spike proteincryo-EMcryoEMcryogenic electron microscopydevelopmentalendothelial dysfunctiongenetic approachgenetic protein engineeringgenetic strategygenome mutationhumAbshuman diseasehuman mAbshuman monoclonal antibodieshuman monoclonalsin vivomAbsmedical countermeasuremembrane assemblymembrane structuremonoclonal Absmouse modelmurine modelmutantnovelpathwayprematureprematuritypriority pathogenprotective efficacyprotein designresolutionssocial rolespike proteins on SARS-CoV-2tick-borne virustickborne virustissue culturevascularviral assemblyviral infectionvirologyvirus host interactionvirus infectionvirus pathogenesisvirus-induced diseasevirus-like nanoparticlesviruslike particle
Description preview
The nairovirus Crimean-Congo hemorrhagic fever virus (CCHFV) causes severe, lethal hemorrhagic disease.
CCHFV is the most prevalent tickborne virus that causes human disease and is endemic in countries across
Europe, Asia, and Africa. No FDA-approved countermeasures are currently available for this NIAID priority
pathogen. As in other…
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