grant
Revealing the transcriptional basis of corticothalamic projections using in situ sequence-based neuroanatomy
NIHUS FederalResearch GrantFY202521+ years oldAdhesion MoleculeAdultAdult HumanAreaBar CodesBasal Transcription FactorBasal transcription factor genesBase SequenceBrainBrain Nervous SystemBrain regionCell Adhesion Molecule GeneCell Adhesion MoleculesCell BodyCellsCerebral cortexComplexComputer ModelsComputerized ModelsDataData SetDevelopmentEncephalonExpression SignatureFoundationsFutureGene ExpressionGene Expression ProfileGene TranscriptionGeneral Transcription Factor GeneGeneral Transcription FactorsGenesGenetic TranscriptionIn SituLinkMapsMeta-AnalysisMethodsMiceMice MammalsModalityModelingMurineMusNatureNerve CellsNerve UnitNeural CellNeuranatomiesNeuranatomyNeuroanatomiesNeuroanatomyNeurocyteNeuronsNon-Polyadenylated RNANucleotide SequencePatternPopulationPositionPositioning AttributePropertyPublishingRNARNA ExpressionRNA Gene ProductsRabies lyssavirusRabies virusResearch ResourcesResolutionResourcesRibonucleic AcidRoleSamplingSindbis VirusSpecific qualifier valueSpecifiedStructureTechniquesThalamic structureThalamusTimeTranscriptionTranscription Factor Proto-OncogeneTranscription factor genesVariantVariationWorkadulthoodanatomical tracingbarcodecell adhesion proteincell typeclass developmentcomputational modelingcomputational modelscomputer based modelscomputerized modelingcortex mappingcortical mapcortical mappingcourse developmentcourse material developmentdevelopmentalgene expression patterngene expression signaturein situ sequencinginsightneuronalneuronal circuitneuronal circuitrynucleic acid sequencepostnatalprogramsreconstructionresolutionsscRNA sequencingscRNA-seqsingle cell RNA-seqsingle cell RNAseqsingle cell expression profilingsingle cell transcriptomic profilingsingle-cell RNA sequencingsocial rolespatial temporal imagingspatial temporal mappingspatiotemporal imagingspatiotemporal mappingthalamictranscription factortranscriptional profiletranscriptional signaturetranscriptomics
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Project Summary
In neuronal circuits, the relationship between gene expression and long-range neuronal projections
defines the structure of circuits and constrains computational models of their functions. In the past few
years, systematic studies on the gene expression and projections of cortical neurons across the whole
cortex have revealed…
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