grant
Retinal Ganglion Cell Signaling Regulated By Intrinsic Reactive Oxygen Species
Organization DOHENY EYE INSTITUTELocation Pasadena, UNITED STATESPosted 1 Aug 2023Deadline 31 Mar 2028
NIHUS FederalResearch GrantFY2025AbscissionAction PotentialsActive OxygenAfferent NeuronsAxonBathingBathsBioenergeticsBiophysical ProcessBlindnessBrainBrain Nervous SystemCell BodyCell Communication and SignalingCell FunctionCell PhysiologyCell ProcessCell SignalingCellsCellular FunctionCellular PhysiologyCellular ProcessClinicalCodeCoding SystemComplexCranial Nerve IICranial Nerve II DiseasesCranial Nerve II DisorderDataDetectionDiagnosisDiagnosticEncephalonEnvironmentExcisionExpenditureExtirpationFailureFeedbackFrequenciesGenerationsGoalsHealthHereditaryInheritedIntermediary MetabolismInterventionIntracellular Communication and SignalingInvestigationIon ChannelIon Channel GatingIon Channel GatingsIonic ChannelsIonsKineticsKnowledgeLightLight CellLinkMediatingMembraneMembrane ChannelsMetabolicMetabolic ProcessesMetabolic stressMetabolismMiceMice MammalsMitochondriaModelingMurineMusNational Eye InstituteNerve CellsNerve DegenerationNerve UnitNeural CellNeural-Optical LesionNeurocyteNeuron DegenerationNeuronsNeurophysiology - biologic functionOptic NerveOptic Nerve DiseasesOptic NeuropathyOutputOxidantsOxidizing AgentsOxygen RadicalsPatch-Clamp TechnicsPatch-Clamp TechniquesPathologicPatternPhenotypePhotoradiationPlayPredispositionPro-OxidantsProcessProductionPropertyProteinsReactive Oxygen SpeciesRemovalResearchResolutionRetinaRetinal DiseasesRetinal DisorderRetinal Ganglion CellsSecond Cranial NerveSecond Cranial Nerve DiseasesSensory NeuronsShapesSightSignal TransductionSignal Transduction SystemsSignalingStimulusStressSubcellular ProcessSurgical RemovalSusceptibilitySynapsesSynapticTestingTransmissionVisionVisualbiological signal transductionbiophysical characteristicsbiophysical characterizationbiophysical measurementbiophysical mechanismbiophysical parametersbiophysical propertiescostelectron acceptorgangliocyteganglion cellimprovedinsightlight intensitymembrane structuremitochondrialneuralneural degenerationneural functionneurodegenerationneurodegenerativeneurological degenerationneuronalneuronal degenerationneuroprotectionneuroprotectivenoveloptic nerve disorderpatch clamppreventpreventingprotein expressionresectionresolutionsresponserestore sightrestore visionretina diseaseretina disorderretinal ganglionretinal neuronretinopathysecond cranial nerve disordersight restorationstemsynapsetheoriestooltransmission processvision lossvision restorationvisual functionvisual informationvisual lossvisual stimulusvoltagevoltage clamp
Description preview
Project Abstract
This proposal to investigate the impact of the bioenergetically-regulated, metabolic environment on the
sensitivity and signaling of retinal ganglion cells blends two converging lines of inquiry. The first arises from
evidence that neuronal metabolic stress is accommodated within diverse and complex solutions. The second
stems…
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