grant
Restoration of ependymal integrity reduces posthemorrhagic hydrocephalus in preterm neonates
Organization ALBERT EINSTEIN COLLEGE OF MEDICINELocation BRONX, UNITED STATESPosted 17 Jul 2024Deadline 31 May 2029
NIHUS FederalResearch GrantFY20253'5'-cyclic ester of AMPATP1A1ATP1A1 geneAdenosine Cyclic 3',5'-MonophosphateAdenosine Cyclic MonophosphateAdenosine, cyclic 3',5'-(hydrogen phosphate)AffectAgonistAnimal ExperimentsApoptosisApoptosis PathwayAqueduct of SylviusAstrocytesAstrocytusAstrogliaAttenuatedAutopsyBasal Transcription FactorBasal transcription factor genesBehaviorBehavioralBleedingBrainBrain Nervous SystemBrain VentricleCSF clearanceCUT&RUNCell BodyCell Communication and SignalingCell ComponentsCell FunctionCell Growth in NumberCell MultiplicationCell PhysiologyCell ProcessCell ProliferationCell SignalingCell StructureCellsCellular FunctionCellular PhysiologyCellular ProcessCellular ProliferationCellular StructuresCerebral PalsyCerebral VentriclesCerebral aqueductChoroid PlexusChronologic Fetal MaturityCiliaCleavage Targets and Release Using NucleaseCleavage Under Targets and Release Using NucleaseCognitive deficitsComplicationCyclic AMPDNA mutationDataDevelopmentDiseaseDisorderDomestic RabbitElectron MicroscopyEncephalonEpendymaEpendymal CellEpendymal TissueEpendymocyteExhibitsFetal AgeFetusGene AlterationGene MutationGene TargetingGeneral Transcription Factor GeneGeneral Transcription FactorsGenesGenetic ChangeGenetic defectGenetic mutationGestational AgeGliaGlial CellsHeadHedgehog (Hh) signal transduction pathwayHemorrhageHistologyHumanHydrocephalusHydrocephalyImmunohistochemistryImmunohistochemistry Cell/TissueImmunohistochemistry Staining MethodInfantInflammationInjuryInterventionIntracellular Communication and SignalingKO miceKnock-out MiceKnockout MiceKolliker's reticulumMeasuresMediatingModelingModern ManMovementMutationNeural Stem CellNeurogliaNeuroglial CellsNeurologicNeurologicalNon-neuronal cellNonneuronal cellNull MouseOryctolagus cuniculusPopulationPremature InfantProductionProgenitor CellsProgrammed Cell DeathProliferatingPseudostratified EpitheliumPublic HealthRabbitsRabbits MammalsRadialRadiusResearchRoleSHHSHH geneSamplingScanning Electron MicroscopySignal PathwaySignal TransductionSignal Transduction SystemsSignalingSliceSonic HedgehogSpecific qualifier valueSpecifiedStructure of choroid plexusSubcellular ProcessSurvivorsTestingTimeTranscription Factor Proto-OncogeneTranscription factor genesTransmission Electron MicroscopyUpregulationVentricularadenosine 3'5' monophosphateanimal experimentastrocytic gliaattenuateattenuatesbiological signal transductionblood lossbody movementcAMPcerebrospinal fluid clearancecerebrospinal fluid flowciliogenesiscilium biogenesiscilium motilitycognitive defectsdensitydevelop therapydevelopmentalexperimental animalexperimental animalsgene defectgenome mutationhedgehog signalinghedgehog signaling pathwayhh signaling pathwayhydrocephalicinfants born prematureinfants born prematurelyinjuriesintervention developmentintraventricular hemorrhagemutantmutant allelenecropsynerve cementnerve stem cellneural precursorneural precursor cellneural progenitorneural progenitor cellsneural stem and progenitor cellsneurobehavioralneurogenic progenitorsneurogenic stem cellneurological recoveryneuron progenitorsneuronal progenitorneuronal progenitor cellsneuronal stem cellsneuroprogenitornew drug treatmentsnew drugsnew pharmacological therapeuticnew therapeuticsnew therapynext generation therapeuticsnovel drug treatmentsnovel drugsnovel pharmaco-therapeuticnovel pharmacological therapeuticnovel therapeuticsnovel therapyoptimal therapiesoptimal treatmentsoverexpressoverexpressionpostmortempostnatalprematurepremature babypremature infant humanpremature neonatespremature newbornprematuritypreterm babypreterm infantpreterm infant humanpreterm neonatepreterm newbornpreventpreventingprogenitor and neural stem cellsprogenitor cell proliferationprogenitor proliferationprogramspurmorphaminerepairrepairedrestorationscRNA sequencingscRNA-seqsingle cell RNA-seqsingle cell RNAseqsingle cell expression profilingsingle cell transcriptomic profilingsingle-cell RNA sequencingsmoothened signaling pathwaysocial rolestem and progenitor cell proliferationstem cell proliferationstem cellssubventricular zonetherapy developmenttranscription factortranscriptomicstreatment developmentultrasound
Description preview
Abstract
About 27% of premature infants weighing less than 1500 g develop intraventricular hemorrhage (IVH). These
infants suffer from post-hemorrhagic hydrocephalus, cerebral palsy, and cognitive deficits. No optimal therapy
exists to prevent or minimize post-IVH hydrocephalus. IVH damages the multiciliated ependyma in the cerebral
ventricles and…
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