grant
Respiratory Drive in Acute Respiratory Failure
Organization NEW YORK UNIVERSITY SCHOOL OF MEDICINELocation NEW YORK, UNITED STATESPosted 15 Jan 2025Deadline 31 Aug 2028
NIHUS FederalResearch GrantFY20253-10CAMCF-IARDSAcute Respiratory DistressAcute Respiratory Distress SyndromeAcute respiratory failureAdult ARDSAdult RDSAdult Respiratory Distress SyndromeAdvanced DevelopmentAng-2Ang2Angiopoietin-2AnxietyAttenuatedAutomobile DrivingBiological MarkersBlood - brain barrier anatomyBlood SerumBlood-Brain BarrierBreathingBreathing MechanicsCO2CXCL8Carbon DioxideCarbonic AnhydrideCarotid BodyChemoreceptorsClinicalClinical DataClinical TrialsCritical IllnessCritically IllCytokine ReceptorsDa Nang LungDataDevelopmentDiaphragmDiaphragm injuryDiaphragmatic injuryDisuse AtrophyElectronic Health RecordEsophagusEvaluationExhalationExhalingExhibitsFutureGCP1Glomus CaroticumHemato-Encephalic BarrierHeterogeneityHospitalsIL-8IL8IL8 geneIndividualInflammationInflammatoryInjuryInjury to DiaphragmInsufflationIntensive Care UnitsInvestigationK60KnowledgeLightLinkLungLung Respiratory SystemLung damageManometryManometry BiochemistryMeasuresMechanical ventilationMechanicsMechanoreceptorsMorbidityMorbidity - disease rateMuscleMuscle TissueO elementO2 elementOutcomeOxygenPainPainfulPathway interactionsPatientsPatternPhotoradiationPhysiciansPre-Clinical ModelPreclinical ModelsPreventionReceptor SignalingRefractoryReportingResearchResidualResidual stateResolutionRespiratory AspirationRespiratory DiaphragmRespiratory ExpirationRespiratory InspirationRespiratory MechanicsRespiratory MusclesRiskSCYB8SamplingSedation procedureSerumShock LungStiff lungStressStructureSyndromeTSG-1TestingTidal VolumeTimeTitrationsVentilatorVentilator-induced lung injuryVentilatory MusclesWorkadjudicationadjudicative process and procedureattenuateattenuatesb-ENAPbio-markersbiologic markerbiomarkerbloodbrain barriercirculating biomarkerscirculating markersclinical diagnosisclinical relevanceclinically relevantcohortcytokinedeath riskdevelopmentaldrivingelectrical impedance tomographyelectronic health care recordelectronic health medical recordelectronic health plan recordelectronic health registryelectronic medical health recordexperiencehigh riskinflammation markerinflammatory markerinjuriesinspirationlung injurymechanicmechanicalmechanical respiratory assistmechanically ventilatedmortalitymortality riskmultiorgan injurymuscularpathwayprematureprematuritypressureprospectivepulmonary damagepulmonary injurypulmonary tissue damagepulmonary tissue injuryresolutionsrespiratoryrespiratory airway volumesedationsystemic inflammationsystemic inflammatory responseultrasoundventilationventilation induced lung injuryventilator associated lung injurywet lung
Description preview
PROJECT SUMMARY/ABSTRACT
Acute respiratory failure (ARF) requiring invasive ventilation occurs in one-third of intensive care unit (ICU)
patients and is associated with a high risk of death. Ventilation-induced lung injury (VILI) is a modifiable
determinant of ARF outcomes that develops when the at-risk lung experiences excessive global or…
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