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Resolving the Paradox of Hearing Complaints with a Normal Audiogram: Differential Diagnosis and Perceptual Impacts of Cochlear Deafferentation

Organization PORTLAND VA MEDICAL CENTERLocation PORTLAND, UNITED STATESPosted 1 Mar 2022Deadline 28 Feb 2026 ⚠️
VANIHUS FederalResearch GrantFY2025Acoustic NerveAlgorithmsAnimal ModelAnimal Models and Related StudiesAudiogramAudiologyAudiometric TestAudiometryAuditoryAuditory Brainstem ResponsesAuditory ThresholdAuditory systemBrain TraumaCausalityCell FunctionCell PhysiologyCell ProcessCellular FunctionCellular PhysiologyCellular ProcessCellular injuryClinicalClinical EvaluationClinical TestingClinical assessmentsCochleaCochlear OrganCognitive deficitsComplexConsensusCranial Nerve EightCranial Nerve VIIIDataDeafferentationDeafferentation procedureDiagnosisDifferential DiagnosisDrug TherapyEarEighth Cranial NerveEnvironmentEtiologyFutureHealthHearingHearing AidsHearing DisordersHearing TestsHearing problemHistoryHyperacusiaHyperacusisInner Hair CellsInner ear hair cellsLeast SquaresLeast-Squares AnalysesLeast-Squares AnalysisLesionLocationLoudnessLoudness Perception DisturbancesLoudness RecruitmentMeasurementMeasuresNatural regenerationNatureNerve FibersNoiseOutcomeOuter Hair CellsPatientsPeripheralPersonsPharmacological TreatmentPharmacotherapyPhysiologicPhysiologicalPopulation HeterogeneityPublishingRecommendationRecording of previous eventsReference RangesReference ValuesReflexReflex actionRegenerationReportingResearchRinging-Buzzing-TinnitusRiskSamplingSiteSpeechSpeech PerceptionStimulusSubcellular ProcessSynapsesSynapticTestingTinnitusTraumatic Brain InjuryTreatment outcomeVIIIth Cranial NerveVestibulocochlear NerveVeteransWeightassistive hearing deviceassistive listening deviceauditory diseaseauditory disorderauditory dysfunctionauditory nerveauditory problemauditory testsaural musclecausationcell damagecell injurycellular damageclinical candidateclinical practiceclinical testcognitive burdencognitive defectscognitive loaddamage to cellsdecreased loudness tolerancedevelop therapydisease causationdiverse populationsdrug interventiondrug treatmentear musclegood hearinghealthy hearinghearing amplificationhearing assessmenthearing assistancehearing assistive devicehearing devicehearing diseasehearing thresholdheterogeneous populationhigh risk grouphigh risk individualhigh risk peoplehigh risk populationhistoriesindividual patientinjury to cellsinnovateinnovationinnovativeintervention developmentloudness intolerancemiddle earmilitary servicemodel of animalnoise exposurenoise sensitivitynormal hearingotoacoustic emissionpatient populationpharmaceutical interventionpharmacological interventionpharmacological therapypharmacology interventionpharmacology treatmentpharmacotherapeuticspopulation diversitypreventpreventingregeneraterepairrepairedresearch clinical testingresponsesexsoundsynapsetherapy developmenttraumatic brain damagetreatment developmentweights

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Description preview

Approximately 10% of Veterans with hearing complaints have clinically normal audiograms. Unfortunately,
treatment options for these patients are limited and the outcomes are variable, resulting in a lack of consensus
on how to manage these patients. Loss of the cochlear synapses between inner hair cells and afferent auditory
nerve fibers can…

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