grant
Research Project 1: Discovery and dissection of virus-host interactions and pathogenetic mechanisms
Organization ALBERT EINSTEIN COLLEGE OF MEDICINELocation BRONX, UNITED STATESPosted 1 Sept 2024Deadline 30 Jun 2029
NIHUS FederalResearch GrantFY20252019-nCoV S protein2019-nCoV spike glycoprotein2019-nCoV spike proteinAlpacaAndes VirusAnimal ModelAnimal Models and Related StudiesAnimalsAntibodiesAntigensAntiseraAssayAutoregulationBioassayBiologicalBiological AssayBleedingBlood SerumBlood VesselsCOVID-19 S proteinCOVID-19 spikeCOVID-19 spike glycoproteinCOVID-19 spike proteinCRISPR approachCRISPR based approachCRISPR methodCRISPR methodologyCRISPR techniqueCRISPR technologyCRISPR toolsCRISPR-CAS-9CRISPR-based methodCRISPR-based techniqueCRISPR-based technologyCRISPR-based toolCRISPR/CAS approachCRISPR/Cas methodCRISPR/Cas technologyCRISPR/Cas9CRISPR/Cas9 technologyCas nuclease technologyCell BodyCell surfaceCellsClinical Treatment MoabClustered Regularly Interspaced Short Palindromic Repeats approachClustered Regularly Interspaced Short Palindromic Repeats methodClustered Regularly Interspaced Short Palindromic Repeats methodologyClustered Regularly Interspaced Short Palindromic Repeats techniqueClustered Regularly Interspaced Short Palindromic Repeats technologyCo-ImmunoprecipitationsCollaborationsCongo VirusCongo hemorrhagic fever virusCrimean Hemorrhagic Fever VirusCrimean-Congo Hemorrhagic Fever VirusCrimean-Congo hemorrhagic fever orthonairovirusCritical PathsCritical PathwaysCulturing, in vitro Vertebrate, PrimaryDataDevelopmentDissectionDysfunctionEndotheliumEngineeringEpitheliumFamilyFlavivirusFoundationsFunctional disorderGenesGeneticGenetic ProcessesGenetic ScreeningGenetics-MutagenesisGlycansGlycoproteinsGoalsGolden HamstersGolden Syrian HamstersGroup B ArbovirusHantavirusHantavirus InfectionsHemorrhageHomeostasisHost FactorHost Factor ProteinHu-mABsHumanImmune SeraImmunizeImmunotherapeutic agentIn VitroInfectionIntegration Host FactorsInterdisciplinary ResearchInterdisciplinary StudyInvestigationKnowledgeLife CycleLife Cycle StagesMammalian CellMapsMass Photometry/Spectrum AnalysisMass SpectrometryMass SpectroscopyMass SpectrumMass Spectrum AnalysesMass Spectrum AnalysisMediatingMesocricetus auratusMiceMice MammalsModelingModern ManMolecularMonoclonal AntibodiesMultidisciplinary CollaborationMultidisciplinary ResearchMurineMusMutagenesisMutagenesis Molecular BiologyNairovirusOrthoflavivirusOrthohantavirusesOrthonairovirusParamyxoviridaeParamyxovirusPathogenesisPathogenicityPathologicPathologyPathway interactionsPermeabilityPhasePhysiological HomeostasisPhysiopathologyPolysaccharidesPositionPositioning AttributePrimary Cell CulturesProductionProteinsProteomicsR-Series Research ProjectsR01 MechanismR01 ProgramReagentReceptor ProteinRecombinantsResearch GrantsResearch Project GrantsResearch ProjectsRodent ModelRoleSARS-CoV-2 SSARS-CoV-2 S proteinSARS-CoV-2 spikeSARS-CoV-2 spike glycoproteinSARS-CoV-2 spike proteinSamplingSerumServicesSevere acute respiratory syndrome coronavirus 2 S proteinSevere acute respiratory syndrome coronavirus 2 spike glycoproteinSevere acute respiratory syndrome coronavirus 2 spike proteinSeverity of illnessSurfaceSyrian HamstersTestingTherapeuticTimeToxinTransgenic AnimalsVSVVaccinatedVaccinesValidationVesicular Stomatitis VirusVesicular stomatitis Indiana virusViralViral DiseasesViral Gene ProductsViral Gene ProteinsViral PathogenesisViral ProteinsVirionVirulenceVirusVirus DiseasesVirus Particleanimal model developmentbiologicbiomarker identificationblood losscandidate validationcoronavirus disease 2019 S proteincoronavirus disease 2019 spike glycoproteincoronavirus disease 2019 spike proteindesigndesigningdevelopmentaldisease severityemergent virusemerging virusendothelial dysfunctionevaluate vaccinesgenetic approachgenetic strategyhumAbshuman mAbshuman monoclonal antibodieshuman monoclonalsidentification of biomarkersidentification of new biomarkersimmune drugsimmune response to vaccinationimmune response to vaccinesimmune serumimmune-based therapeuticsimmunogenimmunologic therapeuticsimmunotherapeuticsimmunotherapy agentin vivoin vivo Modellife coursemAbsmarker identificationmedical countermeasuremembermodel of animalmonoclonal Absnovelpandemic disease preparednesspandemic planningpandemic preparednesspandemic readinesspathophysiologypathwayphospho-proteomicsphosphoproteomicspreventpreventingprotein complexprototypereceptorscreeningscreeningssocial rolespike proteins on SARS-CoV-2vaccine associated immune responsevaccine evaluationvaccine immune responsevaccine immunogenicityvaccine induced immune responsevaccine screeningvaccine strategyvaccine testingvalidationsvascularviral emergenceviral infectionviral infection mechanismvirologyvirus host interactionvirus infectionvirus infection mechanismvirus pathogenesisvirus proteinvirus-induced disease
Description preview
Viruses interact with and hijack a vast array of cellular molecules and pathways to facilitate their multiplication
and spread, while also reprograming infected cells to release pathogenic viral factors (‘viral toxins’) that could
be independently targeted with vaccines and therapeutics to reduce disease severity. Given that virus-host…
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