grant
Reprogramming Double Negative T Cells to Combat Autoimmune Ovarian Failure and Ovarian Tumors
Organization UNIVERSITY OF FLORIDALocation GAINESVILLE, UNITED STATESPosted 1 Apr 2023Deadline 31 Mar 2029
NIHUS FederalResearch GrantFY20263-D3-Dimensional3DAddressAdoptedAdoptive TransferAlzheimer beta-ProteinAlzheimer's Amyloid beta-ProteinAlzheimer's amyloidAmyloid Alzheimer's Dementia Amyloid ProteinAmyloid Beta-PeptideAmyloid Protein A4Amyloid beta-ProteinAmyloid βAmyloid β-PeptideAmyloid β-ProteinAntigensAssayAutoimmuneAutoimmune DiseasesAutoimmune StatusAutoimmunityAutomobile DrivingAutoregulationAβBioassayBiological AssayBody TissuesCD8CD8 CellCD8 T cellsCD8 lymphocyteCD8+ T cellCD8+ T-LymphocyteCD8-Positive LymphocytesCD8-Positive T-LymphocytesCD8BCD8B1CD8B1 geneCannot achieve a pregnancyCell BodyCell CommunicationCell FunctionCell InteractionCell PhysiologyCell ProcessCell ReprogrammingCell TherapyCell-to-Cell InteractionCellsCellular FunctionCellular PhysiologyCellular ProcessChromatinClass I GenesCoACoenzyme AColoring AgentsComplexCuesDevelopmentDifficulty conceivingDissectionDyesEngineeringEpithelial CellsEquilibriumExpression SignatureFecundabilityFecundityFemale HealthFemale infertilityFertilityFutureGene Expression ProfileGene TranscriptionGenetic TranscriptionGranzymeHealthHomeostasisImmuneImmune EvasionImmune ToleranceImmunesImmunologic ToleranceImmunomodulationImmunotherapeutic agentInfertilityInstructionInvestigationKnowledgeLYT3Lentiviral VectorLentivirus VectorMHC Class IMHC Class I GenesMHC ReceptorMajor Histocompatibility Complex ReceptorMalignant Ovarian NeoplasmMalignant Ovarian TumorMalignant Tumor of the OvaryMalignant neoplasm of ovaryMapsMediatingMembraneModelingMolecularMolecular Tumor SuppressionOvarianOvarian TissueOvarian TumorOvaryOvary CancerOvary NeoplasmsOvary TumorPathogenicityPathway interactionsPeripheralPhenotypePhysiological HomeostasisPlayProcessRNA ExpressionReceptor ProteinRegulatory PathwayReportingReproduction ImmunologyReproductive HealthReproductive ImmunologyReproductive NeoplasmReproductive System NeoplasmReproductive System TumorReproductive TumorRoleSafetyStromal CellsSubcellular ProcessSystemT cell responseT-Cell Antigen ReceptorsT-Cell DepletionT-Cell ReceptorT-CellsT-LymphocyteT-cell depletion therapyT-lymphocyte depletion therapyT8 CellsT8 LymphocytesTestingTimeTissuesTranscriptionTreatment EfficacyTumor EscapeTumor Immune EscapeTumor ImmunityTumor SuppressionUterusWomen's HealthWorka beta peptideabetaamyloid betaamyloid-b proteinanti-tumor immune therapyanti-tumor immunityanti-tumor immunotherapyantitumor immunityautoimmune conditionautoimmune disorderautoimmune reactivityautoimmunity diseaseautoreactive T cellautoreactivitybalancebalance functionbeta amyloid fibrilcancer evasioncancer immune escapecancer immune evasioncancer immunitycell based interventioncell mediated interventioncell mediated therapiescell-based therapeuticcell-based therapycellular reprogrammingcellular therapeuticcellular therapycombatcytotoxicdevelopmentaldrivingfertility assistancefertility cessationfertility interventionsfertility lossfertility treatmentgene expression patterngene expression signaturegenital tractimmune check pointimmune checkpointimmune drugsimmune evasiveimmune modulationimmune regulationimmune system toleranceimmune unresponsivenessimmune-based therapeuticsimmunecheckpointimmunogenimmunologic reactivity controlimmunologic therapeuticsimmunological paralysisimmunomodulatoryimmunoregulationimmunoregulatoryimmunotherapeuticsimmunotherapy agentimproved outcomeinfertileinfertility in womeninfertility treatmentinnovateinnovationinnovativeinsightintervention efficacylymphocyte pore-forming proteinmembrane structureneoplasm immunotherapynew approachesnovel approachesnovel strategiesnovel strategyovarian cancerovarian dysfunctionovarian failureovarian neoplasmovulatory dysfunctionpathwayperforinpreservationpreventpreventingprogramsreceptorreproductivereproductive tractrestraintscRNA sequencingscRNA-seqself-reactive T cellsingle cell RNA-seqsingle cell RNAseqsingle cell expression profilingsingle cell transcriptomic profilingsingle-cell RNA sequencingsocial rolesoluble amyloid precursor proteintherapeutic efficacytherapy efficacythree dimensionalthymus derived lymphocytetranscriptional profiletranscriptional signaturetranscriptomicstumortumor evasiontumor immune evasiontumor immune therapytumor immunotherapyunable to bear childrenuptakewomb
Description preview
PROJECT SUMMARY (See instructions):
Double-negative T cells (DNTs), characterized by the absence of CD4 and CDB expression but the
presence of aBeta T cell receptors (TCRs), play a pivotal role in regulating immune homeostasis within the
ovary and uterus. However, how the origin and function of DNTs in the ovary and reproductive tract
remains…
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