grant
Renal Vascular Smooth Muscle NaV Channels: Regulation and Contribution to Hypoperfusion in Neonatal Ischemic Acute Kidney Injury
Organization UNIVERSITY OF MISSOURI-COLUMBIALocation COLUMBIA, UNITED STATESPosted 5 Feb 2026Deadline 30 Nov 2029
NIHUS FederalResearch GrantFY20260-4 weeks old21+ years oldAction PotentialsAcute Kidney FailureAcute Kidney InsufficiencyAcute Renal FailureAcute Renal InsufficiencyAdultAdult HumanArteriesAsphyxiaAttenuatedAutomobile DrivingBasal Transcription FactorBasal transcription factor genesBioavailabilityBiochemicalBiological AvailabilityBlood VesselsBody TissuesCardiacCardiac Muscle CellsCardiac MyocytesCardiac arteryCardiocyteCell BodyCell Communication and SignalingCell SignalingCell membraneCellsCellular injuryChronic Kidney FailureChronic Renal DiseaseChronic Renal FailureClinicalConsciousConsciousnessContractile ProteinsCoronary arteryCytoplasmic MembraneDNA mutationDataDevelopmentDiseaseDisorderDrug or chemical Tissue DistributionDrugsDysfunctionENOSElectrophysiologyElectrophysiology (science)Endogenous Nitrate VasodilatorEndothelial CellsEndothelial Nitric Oxide SynthaseEndotheliumEndothelium-Derived Nitric OxideExhibitsFamily suidaeFunctional disorderGeneral Transcription Factor GeneGeneral Transcription FactorsGenesGenetic ChangeGenetic defectGenetic mutationGlomerular Filtration RateHeart Muscle CellsHeart arteryHeart myocyteHospital AdmissionHospitalizationHypovolemiaHypovolemicsHypoxiaHypoxicImageImpairmentInjury to KidneyIntracellular Communication and SignalingIonsIschemiaIschemia-Reperfusion InjuryIsoformsKidneyKidney Urinary SystemL-Type Calcium ChannelsL-Type VDCCL-Type Voltage-Dependent Calcium ChannelsLeiomyocyteLiquid ChromatographyLong-Lasting Calcium ChannelsMeasurementMediatingMedicationMembraneMembrane Protein GeneMembrane ProteinsMembrane-Associated ProteinsMesenteric ArteriesMethodologyMononitrogen MonoxideMorbidityMorphologyMutationMyocardiumMyographyNOS3NOS3 geneNa elementNa(v)1.1Na+ elementNav1.1NeonatalNeonatal Intensive Care UnitsNephrotoxicNerve CellsNerve UnitNeural CellNeurocyteNeuronsNeurophysiology / ElectrophysiologyNewborn InfantNewborn Intensive Care UnitsNewbornsNitric OxideNitric Oxide DonorsNitric Oxide Synthase 3Nitrogen MonoxideNitrogen ProtoxideNuclearOxygen DeficiencyPathologic ProcessesPathological ProcessesPerfusionPharmaceutical PreparationsPhysiologicPhysiologic AvailabilityPhysiologicalPhysiologyPhysiopathologyPigsPilot ProjectsPlasma MembranePlayPredispositionProtein IsoformsProteinsPublic HealthPulmonary ArteryPulmonary artery structureRegulationRenal Blood FlowRenal VascularRenal vesselsReperfusion DamageReperfusion InjuryReperfusion TherapyResearchRiskRoleSCN1A proteinSepsisShort interfering RNASignal PathwaySignal TransductionSignal Transduction SystemsSignalingSkeletal MuscleSmall Interfering RNASmooth Muscle CellsSmooth Muscle MyocytesSmooth Muscle Tissue CellSodiumSodium ChannelSodium Ion ChannelsStressSuffocationSuidaeSurface ProteinsSusceptibilitySwineSystemTestingTherapeuticTissue DistributionTissuesTranscription Factor Proto-OncogeneTranscription factor genesTransgenic OrganismsType III nitric oxide synthaseVascular DiseasesVascular DisorderVascular PermeabilitiesVascular Smooth MuscleVascular resistanceVoluntary MuscleVulnerable Populationsacute kidney injuryadulthoodasphyxiationattenuateattenuatesbiological signal transductionblood vessel disordercardiac musclecardiomyocytecell damagecell injurycellular damagechronic kidney diseasedamage to cellsdamage to kidneydetermine efficacydevelopmentaldrivingdrug/agentefficacy analysisefficacy assessmentefficacy determinationefficacy evaluationefficacy examinationelectrophysiologicalendothelial cell derived relaxing factorevaluate efficacyexamine efficacyfemoral arterygenome mutationheart musclehypoperfusionimagingimproved outcomeinjury to cellsinsightinterdisciplinary approachkidney damagekidney injurykidney ischemiakidney toxicitykidney vascularkidney vascular structureknock-downknockdownmembrane structuremortalitymultidisciplinarymultidisciplinary approachneonatal ICUneonatenephrotoxicityneuronalnew drug targetnew druggable targetnew pharmacotherapy targetnew therapeutic targetnew therapy targetnewborn childnewborn childrennovelnovel drug targetnovel druggable targetnovel pharmacotherapy targetnovel therapeutic targetnovel therapy targetpatch clamppathophysiologypharmacologicpig modelpiglet modelpilot studyplasmalemmaporcineporcine modelpreventpreventingrenalrenal arteryrenal damagerenal injuryrenal ischemiarenovascularreperfusionresponsesiRNAsocial rolesodium ionsuidswine modeltandem mass spectrometrytherapeutic targettranscription factortransgenictranslational opportunitiestranslational potentialvascularvascular constrictionvascular dysfunctionvasculopathyvasoconstrictionvoltagevulnerable groupvulnerable individualvulnerable people
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Description preview
Voltage-gated sodium (NaV) channels are essential membrane proteins that mediate sodium ion (Na⁺) influx in
response to membrane depolarization. This rapid Na⁺ entry is critical for generating and propagating action
potentials in excitable cells, including neurons, skeletal muscle, and cardiac muscle. The nine functionally
characterized NaV…
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