grant
Remotely-Delivered Cognitive Behavioral Stress Management Effects on Cancer-Accelerated Aging in Older, Distressed Breast Cancer Survivors
Organization UNIVERSITY OF MIAMI CORAL GABLESLocation CORAL GABLES, UNITED STATESPosted 12 Sept 2025Deadline 31 Aug 2029
NIHUS FederalResearch GrantFY2025AccelerationActive Follow-upAddressAdrenal GlandsAdrenalsAerobicAeroseb-HCAffectAfter CareAfter-TreatmentAftercareArea Under CurveB blood cellsB cellB cellsB-CellsB-LymphocytesB-cellBehavioralBloodBlood Reticuloendothelial SystemBreast CancerBreast Cancer survivorCancer CenterCancer SurvivorshipCancer TreatmentCancersCaringCell AgingCell BodyCell PhoneCell SenescenceCellsCellular AgingCellular Immune FunctionCellular Metabolic ProcessCellular PhoneCellular SenescenceCellular TelephoneCessation of lifeCetacortCognition TherapyCognitiveCognitive PsychotherapyCognitive TherapyCognitive treatmentCommunicable DiseasesContinuity of CareContinuity of Patient CareContinuum of CareCoping SkillsCort-DomeCortefCortenemaCortisolCortisprayCortrilDeathDermacortDevelopmentDiagnosisDiseaseDisorderDistalDistressDysfunctionERBB2ERBB2 geneEcological momentary assessmentEducationEducational MaterialsEducational aspectsEldecortEnrollmentFeedbackFunctional disorderHER -2HER-2HER2HER2 GenesHER2/neuHPA axisHR positiveHealthHealth StatusHospitalsHydrocortisoneHydrocortoneHypophysisHypophysis CerebriHypothalamic structureHypothalamusHytoneImmuneImmune DiseasesImmune DisordersImmune DysfunctionImmune System DiseasesImmune System DisorderImmune System DysfunctionImmune System and Related DisordersImmunesImmunologic DiseasesImmunological DiseasesImmunological DysfunctionImmunological System DysfunctionImmunomodulationInfectious DiseasesInfectious DisorderInflammationIntermediary MetabolismInterruptionInterventionInterviewLevel of HealthLinkMalignant Breast NeoplasmMalignant Neoplasm TherapyMalignant Neoplasm TreatmentMalignant NeoplasmsMalignant TumorMeasuresMediatingMediationMental DepressionMental HealthMental HygieneMetabolic ProcessesMetabolismMobile PhonesMonitorMoodsNEU OncogeneNEU proteinNational Institutes of HealthNegotiatingNegotiationNeuroendocrineNeuroendocrine SystemNeuroimmuneNeurosecretory SystemsNutracortOncogene ErbB2OncologyOncology CancerOutcomePaperParasympathetic Nervous SystemParticipantPatientsPersonsPhenotypePhysical assessmentPhysiopathologyPituitaryPituitary GlandPituitary Nervous SystemPopulationPost-MenopausePost-menopausal PeriodPostmenopausal PeriodPostmenopausePredispositionProcessProctocortProtocolProtocols documentationPsychologic AdaptationPsychological AdaptationPsychological HealthPsychological adjustmentQOLQuality of lifeQuestionnairesRandomizedRandomized, Controlled TrialsRecurrent diseaseRegulationRelapsed DiseaseRelaxationReplicative SenescenceResearchRespirationRunningSalivaSalivaryServicesSocial isolationStressStudy modelsSusceptibilityT-CellsT-LymphocyteTKR1Target PopulationsTestingTimeTrainingUnited States National Institutes of HealthVisitVulnerable PopulationsWomanWorkaccelerated agingaccelerated biological ageaccelerated biological agingactive followupadjuvant endocrine therapyadjuvant endocrine treatmentafter menopauseage accelerationage associated effectsage effectage related effectsaging effectaging processanti-cancer therapybiobehaviorbiobehavioralc-erbB-2c-erbB-2 Genesc-erbB-2 Proto-Oncogenescancer carecancer therapycancer-directed therapycare coordinationcell metabolismcellular metabaolismchemotherapyco-morbidco-morbiditycognitive behavior interventioncognitive behavior modificationcognitive behavior therapycognitive behavioral interventioncognitive behavioral modificationcognitive behavioral therapycognitive behavioral treatmentcomorbiditycoordinating carecoping strategydelivered remotelydepressiondevelopmentaldiariesdisease riskdisorder riskeligible participantemotion regulationemotional regulationenrollerbB-2 Genesethnic diversityethnically diversefollow upfollow up assessmentfollow-upfollowed upfollowing menopausefollowupfollowup assessmenthealth levelheart rate variabilityherstatinhormone receptor +hormone receptor-positivehypothalamichypothalamic-pituitary-adrenal (HPA) axishypothalamic-pituitary-adrenal axishypothalmus-pituitary-adrenal axisiPhoneimmune functionimmune modulationimmune regulationimmunologic reactivity controlimmunomodulatoryimmunoregulationimmunoregulatoryimpact of ageimprovedindexinginfluence of ageinterestintervention designintervention effectmalignancymalignant breast tumormeetingmeetingsnatural agingneoplasm/cancerneu Genesnormal agingnormative agingold agepast menopausepathophysiologyperceived stressperception of stressphysical conditioningphysical healthpost treatmentpost-menopausalpostmenopausalpostmenopausal statuspreventpreventingprimary care providerproviders from primary careproviders of primary carepsychosocialrandomisationrandomizationrandomized control trialrandomly assignedremote deliveryremote groupreplicative agingrespiratory mechanismsaliva samplesalivary samplescreeningscreeningssecondary outcomeself-reported stressskillsskills trainingsmart phonesmartphonestandard of carestress bufferingstress managementstress perceptionsuprarenal glandsurvivorshiptelehealththerapy designthymus derived lymphocytetreatment designvulnerable groupvulnerable individualvulnerable peopleweb sitewebsitewristband
Description preview
Protocol Synopsis-Brief Summary
Study Overview. We will enroll Breast Cancer Survivors (BCS) who completed initial treatment
within 3 – 12 months which may or may not have included chemotherapy, are continuing
on adjuvant endocrine therapy (AET), who are distressed, mid-older aged (> 50yrs), post-
menopausal, and were diagnosed with Stage I – III…
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