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Remote cellular reprogramming by non-infectious, pathogenic varicella zoster virus exosomes

Organization UNIVERSITY OF COLORADO DENVERLocation Aurora, UNITED STATESPosted 20 Jun 2024Deadline 30 Apr 2026 ⚠️
NIHUS FederalResearch GrantFY2025(TNF)-α21+ years old3-10CAMCF-IAcicloftalAclovirAcycloguanosineAcyclovirAdultAdult HumanAfferent NeuronsAgingAngiitisAnti-viral AgentsAnti-viral ResponseApoplexyAreaAssayAstrocytesAstrocytusAstrogliaAutonomic ganglionB Cell Differentiation Factor IB cell differentiation factorB cell growth factorB cell growth factor 2B cell stimulating factor 2B-Cell Differentiation FactorB-Cell Differentiation Factor-1B-Cell Differentiation Factor-2B-Cell Growth Factor-1B-Cell Growth Factor-IB-Cell Growth Factor-IIB-Cell Proliferating FactorB-Cell Stimulating FactorB-Cell Stimulating Factor-1B-Cell Stimulation Factor-1B-Cell Stimulatory Factor-1B-Cell Stimulatory Factor-2BCDFBCDF-1BCGFBCGF-1BCGF-IIBCGF2BCSF 1BSF-1BSF-2BSF1BSF2Beta Proprotein Interleukin 1BinetrakinBioassayBiological AssayBiological FunctionBiological ProcessBlood VesselsBody TissuesBrain VascularBrain Vascular AccidentCNS Nervous SystemCSIFCSIF-10CXCL8CachectinCargosilCell BodyCell CommunicationCell InteractionCell ReprogrammingCell-to-Cell InteractionCellsCentral Nervous SystemCerebral StrokeCerebrovascular ApoplexyCerebrovascular StrokeChicken PoxChickenpoxChickenpox VirusChronicCo-StimulatorCostimulatorCranial NervesCytokine Synthesis Inhibitory FactorDataDiagnosisDiameterDiseaseDisorderDistalDistantDorsal RootsDouble-Stranded DNAEndosomesEo-CSFEosinophil Differentiation FactorEpidermal Thymocyte Activating FactorExanthemExanthemaExposure toFibroblastsGCP1Gene TranscriptionGenetic TranscriptionHHV-3HHV3HPGFHSV-1HSV1Hepatocyte-Stimulating FactorHerpes Simplex Type 1Herpes Simplex Virus 1Herpes Simplex Virus Type 1Herpes ZosterHerpes zoster VirusHerpes zoster diseaseHerpesvirus 1Herpesvirus Type 3Herpesvirus varicellaeHourHumanHybridoma Growth FactorIFNIFN-GammaIFN-beta 2IFN-gIFN-γIFNB2IFNGIFNγIL-1 betaIL-1 βIL-1-bIL-10IL-1βIL-2IL-4IL-5IL-6IL-8IL1-BetaIL1-βIL10IL10AIL1B ProteinIL1F2IL1βIL2 ProteinIL4 ProteinIL6 ProteinIL8IL8 geneIgA enhancing factorImmune EvasionImmune InterferonImmune responseImmune systemImmunosuppressionImmunosuppression EffectImmunosuppressive EffectIndividualInfectionInflammationInflammatoryInflammatory MyelopathyInterferon GammaInterferon Type IIInterferonsInterleukin 10 PrecursorInterleukin 1betaInterleukin 2Interleukin 2 PrecursorInterleukin 5 PrecursorInterleukin IIInterleukin-1 betaInterleukin-10Interleukin-1βInterleukin-2Interleukin-4Interleukin-4 PrecursorInterleukin-5Interleukin-6Interleukine 2Interleukine 2 PrecursorInterleukine IIInterventionInvestigatorsK60KeratitisLymphocyte Mitogenic FactorLymphocyte Stimulatory Factor 1MCGF-2MGI-2Macrophage-Derived TNFMass Photometry/Spectrum AnalysisMass SpectrometryMass SpectroscopyMass SpectrumMass Spectrum AnalysesMass Spectrum AnalysisMast Cell Growth Factor-2MediatingMedulla SpinalisMicroRNAsMitogenic FactorModern ManMonocyte-Derived TNFMyelitisMyeloid Differentiation-Inducing ProteinNGS MethodNGS systemNerve CellsNerve UnitNeural CellNeuraxisNeurocyteNeuronsNucleic AcidsOcular Herpes zoster VirusOrganPathogenicityPathologicPathologyPathway interactionsPlasmacytoma Growth FactorPlasmidsPopulationPostherpetic neuralgiaPoviralPreinterleukin 1 BetaPrimary InfectionProcessProteinsProteomicsRNA ExpressionRashReceptosomesResearchResearch PersonnelResearchersRoleSCYB8SensorySensory NeuronsShinglesSiteSkin RashSmall RNASpinal CordSpinal Cord DiseasesSpinal Cord DisordersSpinal Cord InflammationStrokeSystemT cell growth factorT cell replacing factorT-Cell Growth FactorT-Cell Growth Factor 2T-Cell Replacing FactorT-Cell Stimulating FactorTNFTNF ATNF AlphaTNF geneTNF-αTNFATNFαTSG-1TestingThymocyte Stimulating FactorTimeTissuesTranscriptTranscriptionTransfectionTumor Necrosis FactorTumor Necrosis Factor-alphaVZ VirusVZV IE62VZV IE62 proteinVZV ORF62VZV ORF62 proteinVZV gene 62 productVaricellaVaricella-Zoster VirusVascular DiseasesVascular DisorderVasculitisViralViral AntigensViral DiseasesViroraxVirusVirus DiseasesVirus ReplicationZonaZosterZoviraxacute infectionadulthoodanti-viral compoundanti-viral drugsanti-viral medicationanti-viral therapeuticanti-viralsantigen based detectionantigen detectionastrocytic gliab-ENAPblood vessel disorderbrain attackcell typecellular reprogrammingcerebral vascularcerebral vascular accidentcerebro-vascularcerebrovascularcerebrovascular accidentchronic painchronic symptomcytokinedetect antigendevelop therapyds-DNAdsDNAexosomeextracellular vesiclesherpes simplex iherpes simplex-1herpes zonahost responseimmune evasiveimmune suppressionimmune suppressive activityimmune suppressive functionimmune system responseimmunoresponseimmunosuppressive activityimmunosuppressive functionimmunosuppressive responseinflammatory environmentinflammatory milieuinnervationinterferon beta 2intervention developmentlFN-GammamiRNAmyelopathynerve supplyneuronalneurotropic virusnext gen sequencingnext generation sequencingnextgen sequencingnovelpathogenpathwaypermissivenesspersistent symptompost herpetic neuralgiapreventpreventingprogramsresponsesocial rolespinal nerve posterior rootstrokedstrokestherapeutic targettherapy developmenttreatment developmentvaricella-zoster virus IE62varicella-zoster virus immediate early protein 62varicella-zoster virus protein 62vascularvascular dysfunctionvasculitidesvasculopathyviral detectionviral infectionviral multiplicationviral replicationvirus antigenvirus detectionvirus infectionvirus multiplicationvirus-induced disease

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Description preview

PROJECT SUMMARY
Varicella zoster virus (VZV) is an exclusively human, double-stranded DNA alphaherpesvirus that produces
varicella (chickenpox) on primary infection then establishes life-long latency in ganglionic sensory neurons in
>95% of adults. With aging and immunosuppression, VZV reactivates in at least 1 in 3 individuals to produce
zoster…

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